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ENZYME entry: EC 4.4.1.19

Accepted Name
Phosphosulfolactate synthase.
Alternative Name(s)
(2R)-phospho-3-sulfolactate synthase.
PSL synthase.
Reaction catalysed
(2R)-2-O-phospho-3-sulfolactate <=> phosphoenolpyruvate + hydrogen sulfite
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme from Methanococcus jannaschii catalyzes the Michael addition of sulfite to phosphoenolpyruvate.
  • It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite.
Cross-references
BRENDA4.4.1.19
EC2PDB4.4.1.19
ExplorEnz4.4.1.19
PRIAM enzyme-specific profiles4.4.1.19
KEGG Ligand Database for Enzyme Nomenclature4.4.1.19
IUBMB Enzyme Nomenclature4.4.1.19
IntEnz4.4.1.19
MEDLINEFind literature relating to 4.4.1.19
MetaCyc4.4.1.19
Rhea expert-curated reactions4.4.1.19
UniProtKB/Swiss-Prot
O06739, PSLS_BACSU;  Q57703, PSLS_METJA;  O27710, PSLS_METTH;  
Q9AF21, PSLS_XANP2;  

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