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ENZYME

ENZYME entry: EC 4.4.1.36

PURL: https://purl.expasy.org/enzyme/EC/4.4.1.36
Accepted Name
hercynylcysteine S-oxide lyase
Reaction catalysed
S-(hercyn-2-yl)-L-cysteine S-oxide + AH2 + H(+) = ergothioneine + pyruvate + A + NH4(+)
Comment(s)
  • The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyzes the last step in the pathway of ergothioneine biosynthesis.
  • The enzyme forms a 2-sulfenohercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol.
  • In vitro, DTT can serve this function.
Cross-references
BRENDA4.4.1.36
EC2PDB4.4.1.36
ExplorEnz4.4.1.36
KEGG Ligand Database for Enzyme Nomenclature4.4.1.36
IUBMB Enzyme Nomenclature4.4.1.36
MEDLINEFind literature relating to 4.4.1.36
MetaCyc4.4.1.36
Rhea expert-curated reactions4.4.1.36
UniProtKB/Swiss-Prot
A7UX13, EGT2_NEUCRO94431, EGT2_SCHPOA0R5M7, EGTE_MYCS2
Q7D515, EGTE_MYCTOO69668, EGTE_MYCTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-