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ENZYME entry: EC 4.4.1.40

Accepted Name
C-phycoerythrin beta-cysteine-48/59 phycoerythrobilin lyase.
Reaction catalysed
phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]
Comment(s)
  • The enzyme, characterized from the cyanobacterium Microchaete diplosiphon, catalyzes the attachment of the phycobilin chromophore (3E)-phycoerythrobilin (PEB) to cysteine 48 and 59 of the beta subunits of the phycobiliprotein C-phycoerythrin.
  • The enzyme first ligates the A ring of PEB to cysteine-48, followed by the attachment of the D ring to cysteine-59.
  • The numbering used here corresponds to the enzyme from Microchaete diplosiphon, and could vary slightly in other organisms.
  • The reaction requires the presence of the chaperone-like protein CpeZ.
Cross-references
BRENDA4.4.1.40
EC2PDB4.4.1.40
ExplorEnz4.4.1.40
PRIAM enzyme-specific profiles4.4.1.40
KEGG Ligand Database for Enzyme Nomenclature4.4.1.40
IUBMB Enzyme Nomenclature4.4.1.40
IntEnz4.4.1.40
MEDLINEFind literature relating to 4.4.1.40
MetaCyc4.4.1.40
Rhea expert-curated reactions4.4.1.40

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-