Expasy logo

ENZYME

ENZYME entry: EC 4.6.1.18

Accepted Name
pancreatic ribonuclease
Alternative Name(s)
pancreatic RNase
ribonuclease I
RNase
RNase A
RNase I
Reaction catalysed
  • an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]
  • an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]
Comment(s)
  • Specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA.
  • The reaction takes place in two steps, with the 2',3'-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step.
  • Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2'-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3',5'-phosphodiester bonds have been cyclised.
  • The enzyme can act as an endo- or exo ribonuclease.
  • Formerly EC 2.7.7.16, EC 3.1.4.22 and EC 3.1.27.5.
Cross-references
BRENDA4.6.1.18
EC2PDB4.6.1.18
ExplorEnz4.6.1.18
PRIAM enzyme-specific profiles4.6.1.18
KEGG Ligand Database for Enzyme Nomenclature4.6.1.18
IUBMB Enzyme Nomenclature4.6.1.18
IntEnz4.6.1.18
MEDLINEFind literature relating to 4.6.1.18
MetaCyc4.6.1.18
Rhea expert-curated reactions4.6.1.18
UniProtKB/Swiss-Prot
Q9WUR3, RNAS1_ABRJEQ9WTT5, RNAS1_ACOCAP07847, RNAS1_AEPME
P00667, RNAS1_ALCAAP00668, RNAS1_ANTAMQ8SQ06, RNAS1_ATEGE
P87351, RNAS1_AXIPRP00673, RNAS1_BALACP61824, RNAS1_BISBI
P07849, RNAS1_BOSTRP61823, RNAS1_BOVINP00657, RNAS1_BUBBU
P67929, RNAS1_CAMBAP67928, RNAS1_CAMDRP00664, RNAS1_CAPCA
P67926, RNAS1_CAPHIP00663, RNAS1_CERELP84844, RNAS1_CHEMY
P04061, RNAS1_CHESEP00675, RNAS1_CHICHQ9WUV3, RNAS1_CHINI
P61821, RNAS1_CHLAEP00685, RNAS1_CHOHOP00660, RNAS1_CONTA
P24717, RNAS1_CRIGRP00665, RNAS1_DAMDAP00659, RNAS1_DAMKO
P07848, RNAS1_EUDTHP00680, RNAS1_GALMUQ9WUX4, RNAS1_GERGM
Q9WUS2, RNAS1_GERNIP00662, RNAS1_GIRCAQ9WUS1, RNAS1_GLIGL
Q8SQ13, RNAS1_GORGOP00672, RNAS1_HIPAMP00674, RNAS1_HORSE
P07998, RNAS1_HUMANP00677, RNAS1_HYDHYP04060, RNAS1_HYSCR
P80287, RNAS1_IGUIGQ8SQ05, RNAS1_LAGLAQ8SQ04, RNAS1_LEMCA
Q9WUS3, RNAS1_LEOEDQ8SPN5, RNAS1_MACMUP00682, RNAS1_MESAU
P61822, RNAS1_MIOTAP00683, RNAS1_MOUSEQ9QYX3, RNAS1_MUSPA
Q9QYX2, RNAS1_MUSSAP00676, RNAS1_MYOCOQ9WUR4, RNAS1_MYOGA
Q9WUV4, RNAS1_NIVCRQ8SQ11, RNAS1_NOMLEB3EWJ0, RNAS1_NOTRU
P19640, RNAS1_ODOVIP00681, RNAS1_ONDZIQ29606, RNAS1_ORYLE
P00686, RNAS1_OSPRUQ8SQ14, RNAS1_PANTRQ8SQ09, RNAS1_PAPHA
Q9WUV5, RNAS1_PERLEP00671, RNAS1_PIGQ8SQ12, RNAS1_PONPY
P04059, RNAS1_PROGUQ8SPN4, RNAS1_PYGNEP00666, RNAS1_RANTA
Q8SQ07, RNAS1_SAGOEQ8SQ08, RNAS1_SAISCP19644, RNAS1_SEMEN
P67927, RNAS1_SHEEPP16414, RNAS1_SPAEHQ8VD83, RNAS1_SUNME
P00658, RNAS1_TRAORQ9WUX6, RNAS1_URARUO18937, RNAS2_AOTTR
Q8SPY2, RNAS2_CALJAQ8SPY6, RNAS2_CHLAEP47782, RNAS2_GORGO
P10153, RNAS2_HUMANP47783, RNAS2_MACFAQ8SPY5, RNAS2_MACNE
O35291, RNAS2_MOUSEQ8SPY8, RNAS2_NOMLEP47785, RNAS2_PANTR
Q8SPY7, RNAS2_PAPHAP80551, RNAS2_PIGP47784, RNAS2_PONPY
Q8SPY3, RNAS2_SAGLBP47786, RNAS2_SAGOEQ8SPY4, RNAS2_SAISC
P14626, RNASL_AQUCTP15466, RNL1_PIGP00678, RNS1A_CAVPO
Q8VD93, RNS1A_RATEXQ8VD91, RNS1A_RATFUP00679, RNS1B_CAVPO
Q8SPN3, RNS1B_PYGNEP00684, RNS1B_RATQ9WUX3, RNS1B_RATEX
Q8VD84, RNS1B_RATTIQ8VD88, RNS1D_RATQ8VD92, RNS1D_RATEX
Q8VD86, RNS1D_RATRTQ8VD85, RNS1D_RATTIQ8VD89, RNS1G_RAT
Q8VD90, RNS1G_RATFUQ8VD87, RNS1G_RATRTO35292, RNS2B_MOUSE
P00669, RNS_BOVINQ29539, RNS_CEPSIQ29535, RNS_GIRCA
Q29538, RNS_SAITA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-