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ENZYME entry: EC 4.6.1.18

Accepted Name
Pancreatic ribonuclease.
Alternative Name(s)
Pancreatic RNase.
Ribonuclease I.
RNA lyase ((RNA)-3'-cytidine/uridine-3'-phosphate and 5'-hydroxy- ribonucleotide-3'-(RNA) producing).
RNase.
RNase A.
RNase I.
Reaction catalysed
  • An (RNA) containing cytidine + H(2)O <=> an (RNA)-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
  • An (RNA) containing uridine + H(2)O <=> an (RNA)-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Comment(s)
  • Specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA.
  • The reaction takes place in two steps, with the 2',3'-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step.
  • Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2'-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3',5'-phosphodiester bonds have been cyclised.
  • The enzyme can act as an endo- or exo ribonuclease.
  • Formerly EC 2.7.7.16, EC 3.1.4.22 and EC 3.1.27.5.
Cross-references
PROSITEPDOC00118
BRENDA4.6.1.18
EC2PDB4.6.1.18
ExplorEnz4.6.1.18
PRIAM enzyme-specific profiles4.6.1.18
KEGG Ligand Database for Enzyme Nomenclature4.6.1.18
IUBMB Enzyme Nomenclature4.6.1.18
IntEnz4.6.1.18
MEDLINEFind literature relating to 4.6.1.18
MetaCyc4.6.1.18
Rhea expert-curated reactions4.6.1.18
UniProtKB/Swiss-Prot
Q9WUR3, RNAS1_ABRJE;  Q9WTT5, RNAS1_ACOCA;  P07847, RNAS1_AEPME;  
P00667, RNAS1_ALCAA;  P00668, RNAS1_ANTAM;  Q8SQ06, RNAS1_ATEGE;  
P87351, RNAS1_AXIPR;  P00673, RNAS1_BALAC;  P61824, RNAS1_BISBI;  
P07849, RNAS1_BOSTR;  P61823, RNAS1_BOVIN;  P00657, RNAS1_BUBBU;  
P67929, RNAS1_CAMBA;  P67928, RNAS1_CAMDR;  P00664, RNAS1_CAPCA;  
P67926, RNAS1_CAPHI;  P00663, RNAS1_CEREL;  P84844, RNAS1_CHEMY;  
P04061, RNAS1_CHESE;  P00675, RNAS1_CHICH;  Q9WUV3, RNAS1_CHINI;  
P61821, RNAS1_CHLAE;  P00685, RNAS1_CHOHO;  P00660, RNAS1_CONTA;  
P24717, RNAS1_CRIGR;  P00665, RNAS1_DAMDA;  P00659, RNAS1_DAMKO;  
P07848, RNAS1_EUDTH;  P00680, RNAS1_GALMU;  Q9WUX4, RNAS1_GERGM;  
Q9WUS2, RNAS1_GERNI;  P00662, RNAS1_GIRCA;  Q9WUS1, RNAS1_GLIGL;  
Q8SQ13, RNAS1_GORGO;  P00672, RNAS1_HIPAM;  P00674, RNAS1_HORSE;  
P07998, RNAS1_HUMAN;  P00677, RNAS1_HYDHY;  P04060, RNAS1_HYSCR;  
P80287, RNAS1_IGUIG;  Q8SQ05, RNAS1_LAGLA;  Q8SQ04, RNAS1_LEMCA;  
Q9WUS3, RNAS1_LEOED;  Q8SPN5, RNAS1_MACMU;  B3EWJ0, RNAS1_MACRG;  
P00686, RNAS1_MACRU;  P00682, RNAS1_MESAU;  P61822, RNAS1_MIOTA;  
P00683, RNAS1_MOUSE;  Q9QYX3, RNAS1_MUSPA;  Q9QYX2, RNAS1_MUSSA;  
P00676, RNAS1_MYOCO;  Q9WUR4, RNAS1_MYOGA;  Q9WUV4, RNAS1_NIVCR;  
Q8SQ11, RNAS1_NOMLE;  P19640, RNAS1_ODOVI;  P00681, RNAS1_ONDZI;  
Q29606, RNAS1_ORYLE;  Q8SQ14, RNAS1_PANTR;  Q8SQ09, RNAS1_PAPHA;  
Q9WUV5, RNAS1_PERLE;  P00671, RNAS1_PIG;  Q8SQ12, RNAS1_PONPY;  
P04059, RNAS1_PROGU;  Q8SPN4, RNAS1_PYGNE;  P00666, RNAS1_RANTA;  
Q8SQ07, RNAS1_SAGOE;  Q8SQ08, RNAS1_SAISC;  P19644, RNAS1_SEMEN;  
P67927, RNAS1_SHEEP;  P16414, RNAS1_SPAEH;  Q8VD83, RNAS1_SUNME;  
P00658, RNAS1_TRAOR;  Q9WUX6, RNAS1_URARU;  O18937, RNAS2_AOTTR;  
Q8SPY2, RNAS2_CALJA;  Q8SPY6, RNAS2_CHLAE;  P47782, RNAS2_GORGO;  
P10153, RNAS2_HUMAN;  P47783, RNAS2_MACFA;  Q8SPY5, RNAS2_MACNE;  
O35291, RNAS2_MOUSE;  Q8SPY8, RNAS2_NOMLE;  P47785, RNAS2_PANTR;  
Q8SPY7, RNAS2_PAPHA;  P80551, RNAS2_PIG;  P47784, RNAS2_PONPY;  
Q8SPY3, RNAS2_SAGLB;  P47786, RNAS2_SAGOE;  Q8SPY4, RNAS2_SAISC;  
P14626, RNASL_LITCT;  P15466, RNL1_PIG;  P00678, RNS1A_CAVPO;  
Q8VD93, RNS1A_RATEX;  Q8VD91, RNS1A_RATFU;  P00679, RNS1B_CAVPO;  
Q8SPN3, RNS1B_PYGNE;  P00684, RNS1B_RAT;  Q9WUX3, RNS1B_RATEX;  
Q8VD84, RNS1B_RATTI;  Q8VD88, RNS1D_RAT;  Q8VD92, RNS1D_RATEX;  
Q8VD86, RNS1D_RATRT;  Q8VD85, RNS1D_RATTI;  Q8VD89, RNS1G_RAT;  
Q8VD90, RNS1G_RATFU;  Q8VD87, RNS1G_RATRT;  O35292, RNS2B_MOUSE;  
P00669, RNS_BOVIN;  Q29539, RNS_CEPSI;  Q29535, RNS_GIRCA;  
Q29538, RNS_SAITA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.1.-
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