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ENZYME entry: EC 5.1.1.14

Accepted Name
Nocardicin-A epimerase.
Reaction catalysed
  • Isonocardicin C <=> nocardicin C
  • Isonocardicin A <=> nocardicin A
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A.
  • It catalyzes the epimerization of the amino group at position 9' from (S) configuration to (R).
  • The enzyme can act on both isonocardicin A and isonocardicin C, but the in vivo substrate appears to be the latter.
Cross-references
BRENDA5.1.1.14
EC2PDB5.1.1.14
ExplorEnz5.1.1.14
PRIAM enzyme-specific profiles5.1.1.14
KEGG Ligand Database for Enzyme Nomenclature5.1.1.14
IUBMB Enzyme Nomenclature5.1.1.14
IntEnz5.1.1.14
MEDLINEFind literature relating to 5.1.1.14
MetaCyc5.1.1.14
Rhea expert-curated reactions5.1.1.14

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-