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ENZYME entry: EC 5.1.1.17

Accepted Name
Isopenicillin-N epimerase.
Reaction catalysed
Isopenicillin N <=> penicillin N
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, to produce cephalosporins.
  • Forms part of the penicillin biosynthesis pathway.
Cross-references
BRENDA5.1.1.17
EC2PDB5.1.1.17
ExplorEnz5.1.1.17
PRIAM enzyme-specific profiles5.1.1.17
KEGG Ligand Database for Enzyme Nomenclature5.1.1.17
IUBMB Enzyme Nomenclature5.1.1.17
IntEnz5.1.1.17
MEDLINEFind literature relating to 5.1.1.17
MetaCyc5.1.1.17
Rhea expert-curated reactions5.1.1.17
UniProtKB/Swiss-Prot
Q8J0E9, CEFD1_ACRCH;  Q8J0F0, CEFD2_ACRCH;  Q03046, CEFD_AMYLA;  
P18549, CEFD_STRCL;  

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