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ENZYME entry: EC 5.1.1.18

Accepted Name
Serine racemase.
Reaction catalysed
L-serine <=> D-serine
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Highly selective for L-serine as substrate.
  • D-serine is found in type-II astrocytes in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D- aspartate (NMDA) receptors.
  • The reaction can also occur in the reverse direction but does so more slowly at physiological serine concentrations.
Cross-references
PROSITEPDOC00149
BRENDA5.1.1.18
EC2PDB5.1.1.18
ExplorEnz5.1.1.18
PRIAM enzyme-specific profiles5.1.1.18
KEGG Ligand Database for Enzyme Nomenclature5.1.1.18
IUBMB Enzyme Nomenclature5.1.1.18
IntEnz5.1.1.18
MEDLINEFind literature relating to 5.1.1.18
MetaCyc5.1.1.18
Rhea expert-curated reactions5.1.1.18
UniProtKB/Swiss-Prot
Q2PGG3, SRR_ARATH;  A0JNI4, SRR_BOVIN;  Q54HH2, SRR_DICDI;  
Q9GZT4, SRR_HUMAN;  Q9QZX7, SRR_MOUSE;  A2XWA9, SRR_ORYSI;  
Q7XSN8, SRR_ORYSJ;  Q76EQ0, SRR_RAT;  O59791, SRR_SCHPO;  

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