Home  |  Contact
Due to maintenance work, this service and ftp://ftp.expasy.org will be unavailable from Tuesday August 23rd 18:00 until Wednesday August 24th 08:00 CEST. Apologies for the inconvenience.

ENZYME entry: EC

Accepted Name
heparosan-N-sulfate-glucuronate 5-epimerase.
Reaction catalysed
[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)
  • The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate.
  • The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate.
  • It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position.
  • Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation.
  • Not identical with EC or with EC
PRIAM enzyme-specific profiles5.1.3.17
KEGG Ligand Database for Enzyme Nomenclature5.1.3.17
IUBMB Enzyme Nomenclature5.1.3.17
MEDLINEFind literature relating to
Rhea expert-curated reactions5.1.3.17

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-