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ENZYME entry: EC 5.1.3.18

Accepted Name
GDP-mannose 3,5-epimerase.
Reaction catalysed
  • GDP-alpha-D-mannose <=> GDP-beta-L-gulose
  • GDP-beta-L-gulose <=> GDP-beta-L-galactose
Comment(s)
  • The enzyme catalyze the formation of the stable intermediate GDP- beta-L-gulose as well as GDP-beta-L-galactose.
  • The reaction proceeds by C4' oxidation of GDP-alpha-D-mannose followed by epimerization of the C5' position to give GDP-beta-L-4- dehydro-gulose.
  • This intermediate is either reduced to give GDP-beta-L-gulose or the C3' position is epimerized to give GDP-beta-L-4-dehydro-galactose, followed by C4' reduction to yield GDP-beta-L-galactose.
  • Both products serve as intermediates in two different variants of plant L-ascorbate biosynthesis pathways.
Cross-references
BRENDA5.1.3.18
EC2PDB5.1.3.18
ExplorEnz5.1.3.18
PRIAM enzyme-specific profiles5.1.3.18
KEGG Ligand Database for Enzyme Nomenclature5.1.3.18
IUBMB Enzyme Nomenclature5.1.3.18
IntEnz5.1.3.18
MEDLINEFind literature relating to 5.1.3.18
MetaCyc5.1.3.18
Rhea expert-curated reactions5.1.3.18
UniProtKB/Swiss-Prot
A2Z7B3, GME1_ORYSI;  A3C4S4, GME1_ORYSJ;  Q2R1V8, GME2_ORYSJ;  
Q93VR3, GME_ARATH;  

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