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ENZYME

ENZYME entry: EC 5.1.3.24

Accepted Name
N-acetylneuraminate epimerase
Alternative Name(s)
alpha-N-acetylneuraminic acid epimerase
sialic acid epimerase
sialic acid mutarotase
Reaction catalysed
N-acetyl-alpha-neuraminate <=> N-acetyl-beta-neuraminate
Comment(s)
  • Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation.
  • This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction).
  • The open form is necessary for further metabolism by the bacteria.
  • Formerly EC 5.1.3.n1.
Cross-references
BRENDA5.1.3.24
EC2PDB5.1.3.24
ExplorEnz5.1.3.24
PRIAM enzyme-specific profiles5.1.3.24
KEGG Ligand Database for Enzyme Nomenclature5.1.3.24
IUBMB Enzyme Nomenclature5.1.3.24
IntEnz5.1.3.24
MEDLINEFind literature relating to 5.1.3.24
MetaCyc5.1.3.24
Rhea expert-curated reactions5.1.3.24
UniProtKB/Swiss-Prot
Q8CVR2, NANM1_ECOL6Q8CVG5, NANM2_ECOL6Q2YK69, NANM_BRUA2
Q577K1, NANM_BRUABQ8YBP3, NANM_BRUMEA5VU94, NANM_BRUO2
A9WYA0, NANM_BRUSIA7ZVK8, NANM_ECO24Q8X554, NANM_ECO57
A8A834, NANM_ECOHSA1AJH6, NANM_ECOK1Q0T900, NANM_ECOL5
P39371, NANM_ECOLIQ1R2K5, NANM_ECOUTQ4QP39, NANM_HAEI8
A5UB03, NANM_HAEIEA5UFV3, NANM_HAEIGP44544, NANM_HAEIN
Q9CKB7, NANM_PASMUA9MH34, NANM_SALARQ57QM5, NANM_SALCH
B5R066, NANM_SALEPB4T2W1, NANM_SALNSA9N6P2, NANM_SALPB
B4TSP0, NANM_SALSVQ8Z7N0, NANM_SALTIQ8ZQ34, NANM_SALTY
Q31T32, NANM_SHIBSQ0SXL5, NANM_SHIF8Q83IN1, NANM_SHIFL
Q3YU63, NANM_SHISSA5F7B3, NANM_VIBC3Q9KR69, NANM_VIBCH
Q7MD39, NANM_VIBVYA1JMV0, NANM_YERE8A7FJ01, NANM_YERP3
Q1C8L8, NANM_YERPAQ7CI10, NANM_YERPEQ1CHD7, NANM_YERPN
A4TK48, NANM_YERPPQ66BP2, NANM_YERPS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-