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ENZYME entry: EC 5.3.1.14

Accepted Name
L-rhamnose isomerase.
Alternative Name(s)
Rhamnose isomerase.
Reaction catalysed
L-rhamnopyranose <=> L-rhamnulose
Cofactor(s)
Divalent cation.
Comment(s)
  • The enzyme binds the closed ring form of the substrate and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites.
  • Isomerization proceeds via a hydride-shift mechanism.
  • While the enzyme from the bacterium Escherichia coli is specific for L-rhamnose, the enzyme from the bacterium Pseudomonas stutzeri has broad substrate specificity and catalyzes the interconversion of L-mannose and L-fructose, L-lyxose and L-xylulose, D-ribose and D-ribulose, and D-allose and D-psicose.
Cross-references
BRENDA5.3.1.14
EC2PDB5.3.1.14
ExplorEnz5.3.1.14
PRIAM enzyme-specific profiles5.3.1.14
KEGG Ligand Database for Enzyme Nomenclature5.3.1.14
IUBMB Enzyme Nomenclature5.3.1.14
IntEnz5.3.1.14
MEDLINEFind literature relating to 5.3.1.14
MetaCyc5.3.1.14
UniProtKB/Swiss-Prot
Q5WL39, RHAAB_BACSK;  Q9KCL9, RHAA_BACHD;  O05264, RHAA_BACSU;  
Q8A1A2, RHAA_BACTN;  A8AL30, RHAA_CITK8;  A6LQK4, RHAA_CLOB8;  
A7ML61, RHAA_CROS8;  A7ZUB4, RHAA_ECO24;  B7UNM4, RHAA_ECO27;  
B7MI35, RHAA_ECO45;  B7L9F3, RHAA_ECO55;  P58506, RHAA_ECO57;  
B5YZ40, RHAA_ECO5E;  B7NUA3, RHAA_ECO7I;  B7MQZ3, RHAA_ECO81;  
B7M6V5, RHAA_ECO8A;  C5A071, RHAA_ECOBW;  B1XB70, RHAA_ECODH;  
A8A706, RHAA_ECOHS;  A1AI80, RHAA_ECOK1;  Q0TAG0, RHAA_ECOL5;  
Q8FBE0, RHAA_ECOL6;  B1IVH5, RHAA_ECOLC;  P32170, RHAA_ECOLI;  
B7NFK1, RHAA_ECOLU;  B6I4P5, RHAA_ECOSE;  B1LMU3, RHAA_ECOSM;  
A4WG93, RHAA_ENT38;  Q838L2, RHAA_ENTFA;  B7LVE0, RHAA_ESCF3;  
B5XZ52, RHAA_KLEP3;  A6TGA7, RHAA_KLEP7;  Q88S51, RHAA_LACPL;  
Q926R1, RHAA_LISIN;  C1L0I1, RHAA_LISMC;  Q71VR4, RHAA_LISMF;  
B8DCW2, RHAA_LISMH;  Q8Y3I7, RHAA_LISMO;  Q65Q25, RHAA_MANSM;  
Q8ESX0, RHAA_OCEIH;  Q6DA24, RHAA_PECAS;  C6DJR2, RHAA_PECCP;  
Q7UYE5, RHAA_RHOBA;  B5F0M7, RHAA_SALA4;  A9MI67, RHAA_SALAR;  
Q57HH0, RHAA_SALCH;  B5FPP3, RHAA_SALDC;  B5QWY2, RHAA_SALEP;  
B5RFC5, RHAA_SALG2;  B4TBY1, RHAA_SALHS;  B4SZZ1, RHAA_SALNS;  
Q5PKG4, RHAA_SALPA;  A9MZC5, RHAA_SALPB;  C0Q3L2, RHAA_SALPC;  
B5BJG6, RHAA_SALPK;  B4TPQ7, RHAA_SALSV;  Q8Z2V3, RHAA_SALTI;  
P27031, RHAA_SALTY;  Q31U86, RHAA_SHIBS;  Q0SZ93, RHAA_SHIF8;  
Q83IU4, RHAA_SHIFL;  Q3YV73, RHAA_SHISS;  C4LCV5, RHAA_TOLAT;  
A7FN82, RHAA_YERP3;  Q1C0V8, RHAA_YERPA;  B2K1W1, RHAA_YERPB;  
P58507, RHAA_YERPE;  A9QYS2, RHAA_YERPG;  Q1CEB2, RHAA_YERPN;  
A4TRT1, RHAA_YERPP;  Q66FF4, RHAA_YERPS;  B1JNC9, RHAA_YERPY;  

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