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ENZYME entry: EC 5.3.1.25

Accepted Name
L-fucose isomerase.
Reaction catalysed
L-fucopyranose <=> L-fuculose
Cofactor(s)
Mn(2+).
Comment(s)
  • The enzyme binds the closed form of the sugar and catalyzes ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene- diol mechanism.
  • The enzyme from Escherichia coli can also convert D-arabinose to D-ribulose.
  • The enzyme from the thermophilic bacterium Caldicellulosiruptor saccharolyticus also converts D-altrose to D-psicose and L-galactose to L-tagatose.
Cross-references
BRENDA5.3.1.25
EC2PDB5.3.1.25
ExplorEnz5.3.1.25
PRIAM enzyme-specific profiles5.3.1.25
KEGG Ligand Database for Enzyme Nomenclature5.3.1.25
IUBMB Enzyme Nomenclature5.3.1.25
IntEnz5.3.1.25
MEDLINEFind literature relating to 5.3.1.25
MetaCyc5.3.1.25
Rhea expert-curated reactions5.3.1.25
UniProtKB/Swiss-Prot
Q5LIN8, FUCI_BACFN;  Q64ZS4, FUCI_BACFR;  Q9RQ13, FUCI_BACTN;  
A8AP13, FUCI_CITK8;  Q8XNL5, FUCI_CLOPE;  A7ZQP6, FUCI_ECO24;  
B7UHL8, FUCI_ECO27;  B7MLC3, FUCI_ECO45;  B7LEY2, FUCI_ECO55;  
Q8X6R5, FUCI_ECO57;  B5Z4C2, FUCI_ECO5E;  B7NVV0, FUCI_ECO7I;  
B7MZ98, FUCI_ECO81;  B7LXL8, FUCI_ECO8A;  C4ZZV7, FUCI_ECOBW;  
B1XDL1, FUCI_ECODH;  A8A3T7, FUCI_ECOHS;  A1AEY9, FUCI_ECOK1;  
Q0TE57, FUCI_ECOL5;  Q8FEE7, FUCI_ECOL6;  B1IU39, FUCI_ECOLC;  
P69922, FUCI_ECOLI;  B7N736, FUCI_ECOLU;  B6I6K0, FUCI_ECOSE;  
B1LQZ6, FUCI_ECOSM;  Q1R7N8, FUCI_ECOUT;  A5UAS8, FUCI_HAEIE;  
P44779, FUCI_HAEIN;  B5XUY5, FUCI_KLEP3;  A6TD83, FUCI_KLEP7;  
A6L048, FUCI_PHOV8;  B5F4S3, FUCI_SALA4;  A9MSA6, FUCI_SALAR;  
Q57KE0, FUCI_SALCH;  B5FTY1, FUCI_SALDC;  B5QWR0, FUCI_SALEP;  
B5RDV4, FUCI_SALG2;  B4TGN3, FUCI_SALHS;  B4T4X1, FUCI_SALNS;  
Q5PEK9, FUCI_SALPA;  A9N2J1, FUCI_SALPB;  C0PXG5, FUCI_SALPC;  
B5BF31, FUCI_SALPK;  B4TUJ7, FUCI_SALSV;  Q8Z429, FUCI_SALTI;  
Q8ZMC6, FUCI_SALTY;  Q32CB6, FUCI_SHIDS;  Q0T157, FUCI_SHIF8;  
P69923, FUCI_SHIFL;  Q04I16, FUCI_STRP2;  C1CB02, FUCI_STRP7;  
B1I9W8, FUCI_STRPI;  B8ZPZ6, FUCI_STRPJ;  Q97N97, FUCI_STRPN;  
B2INH7, FUCI_STRPS;  Q8DN24, FUCI_STRR6;  C1CHF7, FUCI_STRZJ;  
C1CND0, FUCI_STRZP;  C1CU77, FUCI_STRZT;  Q7MJI2, FUCI_VIBVY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.1.-
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