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ENZYME

ENZYME entry: EC 5.3.1.5

PURL: https://purl.expasy.org/enzyme/EC/5.3.1.5
Accepted Name
xylose isomerase
Alternative Name(s)
D-xylose aldose-ketose-isomerase
D-xylose isomerase
D-xylose ketoisomerase
D-xylose ketol-isomerase
Reaction catalysed
alpha-D-xylose = alpha-D-xylulofuranose
Comment(s)
  • Contains two divalent metal ions, preferably magnesium, located at different metal-binding sites within the active site.
  • The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity.
  • The enzyme binds the closed form of its sugar substrate (in the case of xylose and glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites.
  • Isomerization proceeds via a hydride-shift mechanism.
Cross-references
BRENDA5.3.1.5
EC2PDB5.3.1.5
ExplorEnz5.3.1.5
KEGG Ligand Database for Enzyme Nomenclature5.3.1.5
IUBMB Enzyme Nomenclature5.3.1.5
MEDLINEFind literature relating to 5.3.1.5
MetaCyc5.3.1.5
Rhea expert-curated reactions5.3.1.5
UniProtKB/Swiss-Prot
Q8PLL9, XYLA1_XANACQ4UTU6, XYLA1_XANC8Q8P9T9, XYLA1_XANCP
Q5GYQ7, XYLA1_XANORQ8PEW5, XYLA2_XANACQ4UNZ4, XYLA2_XANC8
Q8P3H1, XYLA2_XANCPQ5GUF2, XYLA2_XANORP12851, XYLA_ACTM4
A3N3K2, XYLA_ACTP2B3H2X9, XYLA_ACTP7B0BTI9, XYLA_ACTPJ
P10654, XYLA_ACTS3A6VLM8, XYLA_ACTSZQ8U7G6, XYLA_AGRFC
B9JSR6, XYLA_ALLAMQ9FKK7, XYLA_ARATHA0JXN9, XYLA_ARTS2
P12070, XYLA_ARTS7Q739D2, XYLA_BACC1Q5LCV9, XYLA_BACFN
Q64U20, XYLA_BACFRP77832, XYLA_BACLDA8FE33, XYLA_BACP2
E0TVS5, XYLA_BACSHP0CI80, XYLA_BACSUP54272, XYLA_BACSW
Q8A9M2, XYLA_BACTNA7Z522, XYLA_BACVZA1A0H0, XYLA_BIFAA
B3DR33, XYLA_BIFLDQ8G3Q1, XYLA_BIFLOQ89VC7, XYLA_BRADU
B2SA37, XYLA_BRUA1Q2YMQ2, XYLA_BRUA2A6X4G3, XYLA_BRUA4
Q57EI4, XYLA_BRUABA9M9H3, XYLA_BRUC2C0RHQ0, XYLA_BRUMB
Q8YFX5, XYLA_BRUMEA5VPA1, XYLA_BRUO2B0CKM9, XYLA_BRUSI
Q8G204, XYLA_BRUSUB1Z405, XYLA_BURA4A0KE56, XYLA_BURCH
B4ENA5, XYLA_BURCJQ0B1U7, XYLA_BURCMA9ARG7, XYLA_BURM1
B1KB47, XYLA_BURO0Q1BG90, XYLA_BURO1Q2SW40, XYLA_BURTA
A4JSU5, XYLA_BURVGB9MPG8, XYLA_CALBDQ9KGU2, XYLA_CALSX
A3PNM4, XYLA_CERS1Q3IYM4, XYLA_CERS4A4WVT8, XYLA_CERS5
B9KPP8, XYLA_CERSKQ11EH9, XYLA_CHESBA5CPC1, XYLA_CLAM3
B0RIF1, XYLA_CLASEA7MNI5, XYLA_CROS8A8LP53, XYLA_DINSH
A7ZTB2, XYLA_ECO24B7ULC6, XYLA_ECO27B7MES1, XYLA_ECO45
B7L6Y0, XYLA_ECO55Q7A9X4, XYLA_ECO57B5YVL8, XYLA_ECO5E
B7NP65, XYLA_ECO7IB7N1L9, XYLA_ECO81B7M3I8, XYLA_ECO8A
C4ZXF6, XYLA_ECOBWB1X8I1, XYLA_ECODHA8A623, XYLA_ECOHS
Q0TBN7, XYLA_ECOL5Q8FCE3, XYLA_ECOL6B1IZM7, XYLA_ECOLC
P00944, XYLA_ECOLIB7NEL7, XYLA_ECOLUB6I3D6, XYLA_ECOSE
B1LJC7, XYLA_ECOSMA4W566, XYLA_ENT38Q7C3R3, XYLA_ENTFA
B7LTH9, XYLA_ESCF3Q6T6K9, XYLA_FERGOQ5KYS6, XYLA_GEOKA
P54273, XYLA_GEOSEA4IP67, XYLA_GEOTNQ4QLI2, XYLA_HAEI8
A5UCZ3, XYLA_HAEIEA5UIN7, XYLA_HAEIGP44398, XYLA_HAEIN
Q9K993, XYLA_HALH5B0UT19, XYLA_HISS2Q40082, XYLA_HORVU
P29442, XYLA_KLEPNQ9CFG7, XYLA_LACLAQ02Y75, XYLA_LACLS
P21938, XYLA_LACPEQ03TX3, XYLA_LEVBAP29443, XYLA_LEVBR
A0AF79, XYLA_LISW6Q65PY0, XYLA_MANSMA6VWH1, XYLA_MARMS
Q2GAB9, XYLA_NOVADQ8ELU7, XYLA_OCEIHB2JFE9, XYLA_PARP8
B2T929, XYLA_PARPJQ13RB8, XYLA_PARXLQ6DB05, XYLA_PECAS
C6DIH5, XYLA_PECCPQ03HN1, XYLA_PEDPAQ7N4P7, XYLA_PHOLL
Q6LUY7, XYLA_PHOPRA6L792, XYLA_PHOV8O08325, XYLA_PRIM3
Q48J73, XYLA_PSE14Q15PG0, XYLA_PSEA6B8HA51, XYLA_PSECP
C3K8E3, XYLA_PSEFSQ3KDW0, XYLA_PSEPFQ880Z4, XYLA_PSESM
Q4ZSF5, XYLA_PSEU2B3Q0R5, XYLA_RHIE6Q2K433, XYLA_RHIEC
Q1MBL8, XYLA_RHIJ3Q98CR8, XYLA_RHILOB5ZQV6, XYLA_RHILW
Q92LW9, XYLA_RHIMEB9JAF5, XYLA_RHIR8Q7UVG2, XYLA_RHOBA
Q162B6, XYLA_ROSDOQ5LV46, XYLA_RUEPOQ1GKQ4, XYLA_RUEST
Q9S306, XYLA_RUMFLB5EX72, XYLA_SALA4Q57IG0, XYLA_SALCH
B5FLD6, XYLA_SALDCB5R4P8, XYLA_SALEPB5RGL6, XYLA_SALG2
B4T952, XYLA_SALHSB4SWK9, XYLA_SALNSQ5PLM6, XYLA_SALPA
A9MUV0, XYLA_SALPBC0Q1C2, XYLA_SALPCB4TZ55, XYLA_SALSV
Q7C637, XYLA_SALTIQ8ZL90, XYLA_SALTYA8G7W8, XYLA_SERP5
B2U560, XYLA_SHIB3Q31V53, XYLA_SHIBSQ3YVV0, XYLA_SHISS
Q5WKJ3, XYLA_SHOC1C3M8Y0, XYLA_SINFNA6UD89, XYLA_SINMW
Q022S9, XYLA_SOLUEP27157, XYLA_STAXYP24299, XYLA_STRAL
Q93HF3, XYLA_STRAWQ9S3Z4, XYLA_STRCKQ9L0B8, XYLA_STRCO
P50910, XYLA_STRDIQ9RFM4, XYLA_STRLIP37031, XYLA_STRMR
Q93RJ9, XYLA_STROIP15587, XYLA_STROLP22857, XYLA_STRRO
P24300, XYLA_STRRUP19149, XYLA_STRS8Q9L558, XYLA_STRTM
P14405, XYLA_STRVNP09033, XYLA_STRVOO82845, XYLA_TETHA
P56681, XYLA_THECAQ9X1Z5, XYLA_THEMAP45687, XYLA_THENE
B9K7G3, XYLA_THENNA5ILR5, XYLA_THEP1P22842, XYLA_THEP3
B0K1L3, XYLA_THEPXP30435, XYLA_THESAB1LB08, XYLA_THESQ
P26997, XYLA_THET8P29441, XYLA_THETCP19148, XYLA_THETU
Q3BMF2, XYLA_XANE5Q2NXR2, XYLA_XANOMA1JT10, XYLA_YERE8
A7FP68, XYLA_YERP3Q1C0D3, XYLA_YERPAB2K7D2, XYLA_YERPB
Q8Z9Z1, XYLA_YERPEA9R5Q1, XYLA_YERPGQ1CDB8, XYLA_YERPN
A4TS63, XYLA_YERPPQ663Y3, XYLA_YERPSB1JH40, XYLA_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-