A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 5.3.3.12
| Accepted Name |
|---|
| L-dopachrome isomerase.
|
| Alternative Name(s) |
|---|
| DCF. |
| DCT. |
| Dopachrome conversion factor. |
| Dopachrome Delta(7),Delta(2)-isomerase. |
| Dopachrome Delta-isomerase. |
| Dopachrome isomerase. |
| Dopachrome keto-enol isomerase. |
| Dopachrome oxidoreductase. |
| Dopachrome rearranging enzyme. |
| Dopachrome tautomerase. |
| L-dopachrome-methyl ester tautomerase. |
| TRP. |
| Tyrosinase-related protein 2. |
| Reaction catalysed |
|---|
| L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate |
| Cofactor(s) |
|---|
| Zn(2+).
|
| Comment(s) |
|---|
- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole-
2-carboxylate).
- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-
dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
|
| Cross-references |
|---|
| PROSITE | PDOC00398 |
| BRENDA | 5.3.3.12 |
| EC2PDB | 5.3.3.12 |
| ExplorEnz | 5.3.3.12 |
| PRIAM enzyme-specific profiles | 5.3.3.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 5.3.3.12 |
| IUBMB Enzyme Nomenclature | 5.3.3.12 |
| IntEnz | 5.3.3.12 |
| MEDLINE | Find literature relating to 5.3.3.12 |
| MetaCyc | 5.3.3.12 |
| UniProtKB/Swiss-Prot |
| P91850, MIFH_BRUMA; | P81530, MIFH_TRIMR; | P81529, MIFH_TRISP; |
| P81748, MIFH_TRITR; | O44786, MIFH_WUCBA; | P80177, MIF_BOVIN; |
| Q02960, MIF_CHICK; | P14174, MIF_HUMAN; | Q4R549, MIF_MACFA; |
| Q6DN04, MIF_MACMU; | O55052, MIF_MERUN; | P34884, MIF_MOUSE; |
| P80928, MIF_PIG; | P30904, MIF_RAT; | Q1ZZU7, MIF_SHEEP; |
| Q76BK2, MIF_XENLA; | A9JSE7, MIF_XENTR; | Q95119, TYRP2_BOVIN; |
| O93505, TYRP2_CHICK; | P40126, TYRP2_HUMAN; | P29812, TYRP2_MOUSE; |
| Q4R1H1, TYRP2_PIG; | Q9VG08, YELF2_DROME; | Q9VG09, YELF_DROME; |
|
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