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ENZYME

ENZYME entry: EC 5.3.3.12

PURL: https://purl.expasy.org/enzyme/EC/5.3.3.12
Accepted Name
L-dopachrome isomerase
Alternative Name(s)
DCF
DCT
dopachrome conversion factor
dopachrome Delta(7),Delta(2)-isomerase
dopachrome Delta-isomerase
dopachrome isomerase
dopachrome keto-enol isomerase
dopachrome oxidoreductase
dopachrome rearranging enzyme
dopachrome tautomerase
L-dopachrome-methyl ester tautomerase
TRP
tyrosinase-related protein 2
Reaction catalysed
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
Comment(s)
  • Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate).
  • Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
Cross-references
BRENDA5.3.3.12
EC2PDB5.3.3.12
ExplorEnz5.3.3.12
KEGG Ligand Database for Enzyme Nomenclature5.3.3.12
IUBMB Enzyme Nomenclature5.3.3.12
MEDLINEFind literature relating to 5.3.3.12
MetaCyc5.3.3.12
Rhea expert-curated reactions5.3.3.12
UniProtKB/Swiss-Prot
P91850, MIFH_BRUMAP81530, MIFH_TRIMRP81529, MIFH_TRISP
P81748, MIFH_TRITRO44786, MIFH_WUCBAP80177, MIF_BOVIN
Q02960, MIF_CHICKP14174, MIF_HUMANQ4R549, MIF_MACFA
Q6DN04, MIF_MACMUO55052, MIF_MERUNP34884, MIF_MOUSE
P80928, MIF_PIGP30904, MIF_RATQ1ZZU7, MIF_SHEEP
Q76BK2, MIF_XENLAA9JSE7, MIF_XENTRQ95119, TYRP2_BOVIN
O93505, TYRP2_CHICKP40126, TYRP2_HUMANP29812, TYRP2_MOUSE
Q4R1H1, TYRP2_PIGQ9VG08, YELF2_DROMEQ9VG09, YELF_DROME

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