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ENZYME entry: EC 5.3.3.21

Accepted Name
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase.
Alternative Name(s)
3,5-tetradecadienoyl-CoA isomerase.
Reaction catalysed
A (3E,5Z)-alka-3,5-dienoyl-CoA <=> a (2E,4E)-alka-2,4-dienoyl-CoA
Comment(s)
  • The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate.
  • The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl- CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates.
Cross-references
BRENDA5.3.3.21
EC2PDB5.3.3.21
ExplorEnz5.3.3.21
PRIAM enzyme-specific profiles5.3.3.21
KEGG Ligand Database for Enzyme Nomenclature5.3.3.21
IUBMB Enzyme Nomenclature5.3.3.21
IntEnz5.3.3.21
MEDLINEFind literature relating to 5.3.3.21
MetaCyc5.3.3.21
Rhea expert-curated reactions5.3.3.21
UniProtKB/Swiss-Prot
Q9FHR8, DCI1_ARATH

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