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ENZYME entry: EC 5.3.3.8

Accepted Name
Delta(3)-Delta(2)-enoyl-CoA isomerase.
Alternative Name(s)
3,2-trans-enoyl-CoA isomerase.
Acetylene-allene isomerase.
Delta(3),Delta(2)-enoyl-CoA isomerase.
Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase.
Dodecenoyl-CoA Delta-isomerase.
Dodecenoyl-CoA isomerase.
Reaction catalysed
  • A (3Z)-alk-3-enoyl-CoA <=> a (2E)-alk-2-enoyl-CoA
  • A (3E)-alk-3-enoyl-CoA <=> a (2E)-alk-2-enoyl-CoA
Comment(s)
  • The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position.
  • Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C(3), which cannot be processed further by the regular enzymes of the beta- oxidation system.
  • This enzyme isomerizes the bond to a trans bond at position C(2), which can be processed further.
  • The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers.
  • The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
Cross-references
BRENDA5.3.3.8
EC2PDB5.3.3.8
ExplorEnz5.3.3.8
PRIAM enzyme-specific profiles5.3.3.8
KEGG Ligand Database for Enzyme Nomenclature5.3.3.8
IUBMB Enzyme Nomenclature5.3.3.8
IntEnz5.3.3.8
MEDLINEFind literature relating to 5.3.3.8
MetaCyc5.3.3.8
UniProtKB/Swiss-Prot
Q9ZPI6, AIM1_ARATH;  P55100, ECHP_CAVPO;  Q6NYL3, ECHP_DANRE;  
Q08426, ECHP_HUMAN;  Q9DBM2, ECHP_MOUSE;  Q5R5M8, ECHP_PONAB;  
P07896, ECHP_RAT;  O04469, ECI1_ARATH;  P42126, ECI1_HUMAN;  
P42125, ECI1_MOUSE;  P23965, ECI1_RAT;  Q05871, ECI1_YEAST;  
O23299, ECI2_ARATH;  O75521, ECI2_HUMAN;  Q9WUR2, ECI2_MOUSE;  
Q5XIC0, ECI2_RAT;  O23300, ECI3_ARATH;  Q78JN3, ECI3_MOUSE;  
Q4UL32, FAD3_RICFE;  Q9ZCZ1, FAD3_RICPR;  Q68WH7, FAD3_RICTY;  
Q6FF68, FADB_ACIAD;  B7H1I0, FADB_ACIB3;  B7I3P1, FADB_ACIB5;  
B2I2J9, FADB_ACIBC;  B0VLX4, FADB_ACIBS;  B0VE45, FADB_ACIBY;  
A0KEL1, FADB_AERHH;  A4STF2, FADB_AERS4;  Q5E8X6, FADB_ALIF1;  
B5FEW8, FADB_ALIFM;  B6EGU2, FADB_ALISL;  A8ACZ4, FADB_CITK8;  
Q489W3, FADB_COLP3;  A7MQP0, FADB_CROS8;  A7ZU51, FADB_ECO24;  
B7UNH4, FADB_ECO27;  B7MHD1, FADB_ECO45;  B7L9A7, FADB_ECO55;  
Q8X8I2, FADB_ECO57;  B5YY93, FADB_ECO5E;  B7NV20, FADB_ECO7I;  
B7N2F2, FADB_ECO81;  B7M649, FADB_ECO8A;  C5A020, FADB_ECOBW;  
B1XAK8, FADB_ECODH;  A8A6V1, FADB_ECOHS;  Q0TAL0, FADB_ECOL5;  
Q8FBI2, FADB_ECOL6;  B1IW61, FADB_ECOLC;  P21177, FADB_ECOLI;  
B7NFE7, FADB_ECOLU;  B6I4I6, FADB_ECOSE;  B1LM32, FADB_ECOSM;  
Q1R466, FADB_ECOUT;  A4WFX4, FADB_ENT38;  Q9F0Y7, FADB_ENTCL;  
B7LTY9, FADB_ESCF3;  Q5QXH7, FADB_IDILO;  B5XYH0, FADB_KLEP3;  
A6TGM4, FADB_KLEP7;  Q6DAP5, FADB_PECAS;  Q7MZ92, FADB_PHOLL;  
Q6LW06, FADB_PHOPR;  Q48GW3, FADB_PSE14;  A6V382, FADB_PSEA7;  
B7UYR6, FADB_PSEA8;  Q02PH8, FADB_PSEAB;  Q9HZJ2, FADB_PSEAE;  
Q1I7D4, FADB_PSEE4;  Q4KFC4, FADB_PSEF5;  P28793, FADB_PSEFR;  
C3K613, FADB_PSEFS;  A4XSM8, FADB_PSEMY;  Q93Q12, FADB_PSEOL;  
A5W6H0, FADB_PSEP1;  Q3K9D8, FADB_PSEPF;  B0KH74, FADB_PSEPG;  
Q88L02, FADB_PSEPK;  Q9AHY3, FADB_PSEPU;  B1J5A5, FADB_PSEPW;  
Q87ZB2, FADB_PSESM;  Q4ZRA0, FADB_PSEU2;  A4VKA3, FADB_PSEU5;  
Q4FQC6, FADB_PSYA2;  Q1Q8J9, FADB_PSYCK;  A5WH99, FADB_PSYWF;  
B5EZW0, FADB_SALA4;  Q57HM6, FADB_SALCH;  B5QW85, FADB_SALEP;  
B5RFL6, FADB_SALG2;  B4SZ85, FADB_SALNS;  Q5PKQ2, FADB_SALPA;  
A9MYB0, FADB_SALPB;  B5BIZ0, FADB_SALPK;  B4TNZ1, FADB_SALSV;  
Q8Z3C6, FADB_SALTI;  Q9L6L5, FADB_SALTY;  A8G8D1, FADB_SERP5;  
A1S1I8, FADB_SHEAM;  B8E3R3, FADB_SHEB2;  A3CYJ4, FADB_SHEB5;  
A6WHA0, FADB_SHEB8;  A9KU91, FADB_SHEB9;  Q08A39, FADB_SHEFN;  
B0TLB9, FADB_SHEHH;  A3Q8U4, FADB_SHELP;  Q8EKR9, FADB_SHEON;  
A8GYG0, FADB_SHEPA;  A4Y1B6, FADB_SHEPC;  B8CH91, FADB_SHEPW;  
A0KR50, FADB_SHESA;  A8FP63, FADB_SHESH;  Q0HPB7, FADB_SHESM;  
Q0I0T3, FADB_SHESR;  A1RDW6, FADB_SHESW;  B1KCZ3, FADB_SHEWM;  
B2TVJ5, FADB_SHIB3;  Q32A21, FADB_SHIDS;  Q0SZ36, FADB_SHIF8;  
Q83PG1, FADB_SHIFL;  Q3YVC1, FADB_SHISS;  A5F465, FADB_VIBC3;  
A7N1D2, FADB_VIBCB;  Q9KNI1, FADB_VIBCH;  C3LSI3, FADB_VIBCM;  
Q87TN9, FADB_VIBPA;  B7VGL4, FADB_VIBTL;  Q8DDK6, FADB_VIBVU;  
Q7MQH9, FADB_VIBVY;  A1JIG4, FADB_YERE8;  A7FDF2, FADB_YERP3;  
Q1C2C4, FADB_YERPA;  B2K0Z6, FADB_YERPB;  Q8ZAN0, FADB_YERPE;  
A9R754, FADB_YERPG;  Q1CN99, FADB_YERPN;  A4TR27, FADB_YERPP;  
Q66FR8, FADB_YERPS;  B1JP63, FADB_YERPY;  Q9ZPI5, MFP2_ARATH;  
O49809, MFPA_BRANA;  Q39659, MFPA_CUCSA;  Q8W1L6, MFP_ORYSJ;  

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