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ENZYME

ENZYME entry: EC 5.3.3.8

Accepted Name
Delta(3)-Delta(2)-enoyl-CoA isomerase
Alternative Name(s)
3,2-trans-enoyl-CoA isomerase
acetylene-allene isomerase
Delta(3),Delta(2)-enoyl-CoA isomerase
Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase
dodecenoyl-CoA Delta-isomerase
dodecenoyl-CoA isomerase
Reaction catalysed
  • a (3Z)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA
  • a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA
Comment(s)
  • The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position.
  • Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C3, which cannot be processed further by the regular enzymes of the beta- oxidation system.
  • This enzyme isomerizes the bond to a trans bond at position C2, which can be processed further.
  • The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers.
  • The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
Cross-references
BRENDA5.3.3.8
EC2PDB5.3.3.8
ExplorEnz5.3.3.8
PRIAM enzyme-specific profiles5.3.3.8
KEGG Ligand Database for Enzyme Nomenclature5.3.3.8
IUBMB Enzyme Nomenclature5.3.3.8
IntEnz5.3.3.8
MEDLINEFind literature relating to 5.3.3.8
MetaCyc5.3.3.8
Rhea expert-curated reactions5.3.3.8
UniProtKB/Swiss-Prot
Q9ZPI6, AIM1_ARATHQ58DM8, ECHM_BOVINP30084, ECHM_HUMAN
Q8BH95, ECHM_MOUSEQ5R646, ECHM_PONABP14604, ECHM_RAT
P55100, ECHP_CAVPOQ6NYL3, ECHP_DANREQ08426, ECHP_HUMAN
Q9DBM2, ECHP_MOUSEQ5R5M8, ECHP_PONABP07896, ECHP_RAT
O04469, ECI1_ARATHP42126, ECI1_HUMANP42125, ECI1_MOUSE
P23965, ECI1_RATQ05871, ECI1_YEASTO23299, ECI2_ARATH
O75521, ECI2_HUMANQ9WUR2, ECI2_MOUSEQ5XIC0, ECI2_RAT
O23300, ECI3_ARATHQ78JN3, ECI3_MOUSEQ4UL32, FAD3_RICFE
Q9ZCZ1, FAD3_RICPRQ68WH7, FAD3_RICTYQ6FF68, FADB_ACIAD
B7H1I0, FADB_ACIB3B7I3P1, FADB_ACIB5B2I2J9, FADB_ACIBC
B0VLX4, FADB_ACIBSB0VE45, FADB_ACIBYA0KEL1, FADB_AERHH
A4STF2, FADB_AERS4Q5E8X6, FADB_ALIF1B5FEW8, FADB_ALIFM
B6EGU2, FADB_ALISLA8ACZ4, FADB_CITK8Q489W3, FADB_COLP3
A7MQP0, FADB_CROS8A7ZU51, FADB_ECO24B7UNH4, FADB_ECO27
B7MHD1, FADB_ECO45B7L9A7, FADB_ECO55Q8X8I2, FADB_ECO57
B5YY93, FADB_ECO5EB7NV20, FADB_ECO7IB7N2F2, FADB_ECO81
B7M649, FADB_ECO8AC5A020, FADB_ECOBWB1XAK8, FADB_ECODH
A8A6V1, FADB_ECOHSQ0TAL0, FADB_ECOL5Q8FBI2, FADB_ECOL6
B1IW61, FADB_ECOLCP21177, FADB_ECOLIB7NFE7, FADB_ECOLU
B6I4I6, FADB_ECOSEB1LM32, FADB_ECOSMQ1R466, FADB_ECOUT
A4WFX4, FADB_ENT38Q9F0Y7, FADB_ENTCLB7LTY9, FADB_ESCF3
Q5QXH7, FADB_IDILOB5XYH0, FADB_KLEP3A6TGM4, FADB_KLEP7
Q6DAP5, FADB_PECASQ7MZ92, FADB_PHOLLQ6LW06, FADB_PHOPR
Q48GW3, FADB_PSE14A6V382, FADB_PSEA7B7UYR6, FADB_PSEA8
Q02PH8, FADB_PSEABQ9HZJ2, FADB_PSEAEQ1I7D4, FADB_PSEE4
Q4KFC4, FADB_PSEF5P28793, FADB_PSEFRC3K613, FADB_PSEFS
A4XSM8, FADB_PSEMYQ93Q12, FADB_PSEOLA5W6H0, FADB_PSEP1
Q3K9D8, FADB_PSEPFB0KH74, FADB_PSEPGQ88L02, FADB_PSEPK
Q9AHY3, FADB_PSEPUB1J5A5, FADB_PSEPWQ87ZB2, FADB_PSESM
Q4ZRA0, FADB_PSEU2Q4FQC6, FADB_PSYA2Q1Q8J9, FADB_PSYCK
A5WH99, FADB_PSYWFB5EZW0, FADB_SALA4Q57HM6, FADB_SALCH
B5QW85, FADB_SALEPB5RFL6, FADB_SALG2B4SZ85, FADB_SALNS
Q5PKQ2, FADB_SALPAA9MYB0, FADB_SALPBB5BIZ0, FADB_SALPK
B4TNZ1, FADB_SALSVQ8Z3C6, FADB_SALTIQ9L6L5, FADB_SALTY
A8G8D1, FADB_SERP5A1S1I8, FADB_SHEAMB8E3R3, FADB_SHEB2
A3CYJ4, FADB_SHEB5A6WHA0, FADB_SHEB8A9KU91, FADB_SHEB9
Q08A39, FADB_SHEFNB0TLB9, FADB_SHEHHA3Q8U4, FADB_SHELP
Q8EKR9, FADB_SHEONA8GYG0, FADB_SHEPAA4Y1B6, FADB_SHEPC
B8CH91, FADB_SHEPWA0KR50, FADB_SHESAA8FP63, FADB_SHESH
Q0HPB7, FADB_SHESMQ0I0T3, FADB_SHESRA1RDW6, FADB_SHESW
B1KCZ3, FADB_SHEWMB2TVJ5, FADB_SHIB3Q32A21, FADB_SHIDS
Q0SZ36, FADB_SHIF8Q83PG1, FADB_SHIFLQ3YVC1, FADB_SHISS
A4VKA3, FADB_STUS1B7VGL4, FADB_VIBA3A7N1D2, FADB_VIBC1
A5F465, FADB_VIBC3Q9KNI1, FADB_VIBCHC3LSI3, FADB_VIBCM
Q87TN9, FADB_VIBPAQ8DDK6, FADB_VIBVUQ7MQH9, FADB_VIBVY
A1JIG4, FADB_YERE8A7FDF2, FADB_YERP3Q1C2C4, FADB_YERPA
B2K0Z6, FADB_YERPBQ8ZAN0, FADB_YERPEA9R754, FADB_YERPG
Q1CN99, FADB_YERPNA4TR27, FADB_YERPPQ66FR8, FADB_YERPS
B1JP63, FADB_YERPYQ9ZPI5, MFP2_ARATHO49809, MFPA_BRANA
Q39659, MFPA_CUCSAQ8W1L6, MFP_ORYSJ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-