ENZYME entry: EC 5.3.99.3
Accepted Name |
Prostaglandin-E synthase.
|
Alternative Name(s) |
Endoperoxide isomerase. |
PGE isomerase. |
PGH-PGE isomerase. |
Prostaglandin-H(2) E-isomerase. |
Reaction catalysed |
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate <=> (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate |
Cofactor(s) |
Glutathione.
|
Comment(s) |
Brings about the opening of the epidioxy bridge.
|
Cross-references |
BRENDA | 5.3.99.3 |
EC2PDB | 5.3.99.3 |
ExplorEnz | 5.3.99.3 |
PRIAM enzyme-specific profiles | 5.3.99.3 |
KEGG Ligand Database for Enzyme Nomenclature | 5.3.99.3 |
IUBMB Enzyme Nomenclature | 5.3.99.3 |
IntEnz | 5.3.99.3 |
MEDLINE | Find literature relating to 5.3.99.3 |
MetaCyc | 5.3.99.3 |
Rhea expert-curated reactions | 5.3.99.3 |
UniProtKB/Swiss-Prot |
Q66LN0, PGES2_BOVIN; | Q7ZUC7, PGES2_DANRE; | Q9H7Z7, PGES2_HUMAN; |
Q9N0A4, PGES2_MACFA; | Q8BWM0, PGES2_MOUSE; | Q95L14, PTGES_BOVIN; |
A0SYQ0, PTGES_CANLF; | Q8HZJ2, PTGES_HORSE; | O14684, PTGES_HUMAN; |
Q6PWL6, PTGES_MACFA; | Q9JM51, PTGES_MOUSE; | Q9JHF3, PTGES_RAT; |
Q3ZBF7, TEBP_BOVIN; | Q90955, TEBP_CHICK; | Q15185, TEBP_HUMAN; |
Q6PWL5, TEBP_MACFA; | Q9R0Q7, TEBP_MOUSE; | Q5NVM4, TEBP_PONAB; |
G1TGF1, TEBP_RABIT; | P83868, TEBP_RAT; |
|
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UniProtKB/Swiss-Prot entries corresponding to 5.3.99.-
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