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ENZYME entry: EC 5.3.99.3

Accepted Name
Prostaglandin-E synthase.
Alternative Name(s)
Endoperoxide isomerase.
PGE isomerase.
PGH-PGE isomerase.
Prostaglandin-H(2) E-isomerase.
Reaction catalysed
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate <=> (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
Cofactor(s)
Glutathione.
Comment(s)
Brings about the opening of the epidioxy bridge.
Cross-references
BRENDA5.3.99.3
EC2PDB5.3.99.3
ExplorEnz5.3.99.3
PRIAM enzyme-specific profiles5.3.99.3
KEGG Ligand Database for Enzyme Nomenclature5.3.99.3
IUBMB Enzyme Nomenclature5.3.99.3
IntEnz5.3.99.3
MEDLINEFind literature relating to 5.3.99.3
MetaCyc5.3.99.3
Rhea expert-curated reactions5.3.99.3
UniProtKB/Swiss-Prot
Q66LN0, PGES2_BOVIN;  Q7ZUC7, PGES2_DANRE;  Q9H7Z7, PGES2_HUMAN;  
Q9N0A4, PGES2_MACFA;  Q8BWM0, PGES2_MOUSE;  Q95L14, PTGES_BOVIN;  
A0SYQ0, PTGES_CANLF;  Q8HZJ2, PTGES_HORSE;  O14684, PTGES_HUMAN;  
Q6PWL6, PTGES_MACFA;  Q9JM51, PTGES_MOUSE;  Q9JHF3, PTGES_RAT;  
Q3ZBF7, TEBP_BOVIN;  Q90955, TEBP_CHICK;  Q15185, TEBP_HUMAN;  
Q6PWL5, TEBP_MACFA;  Q9R0Q7, TEBP_MOUSE;  Q5NVM4, TEBP_PONAB;  
G1TGF1, TEBP_RABIT;  P83868, TEBP_RAT;  

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