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ENZYME

ENZYME entry: EC 5.4.2.12

Accepted Name
phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
Alternative Name(s)
2,3-diphosphoglycerate-independent phosphoglycerate mutase
cofactor independent phosphoglycerate mutase
phosphoglycerate phosphomutase
phosphoglyceromutase
Reaction catalysed
(2R)-2-phosphoglycerate <=> (2R)-3-phosphoglycerate
Comment(s)
  • The enzymes from higher plants, algae, some fungi, nematodes, sponges, coelenterates, myriapods, arachnids, echinoderms, archaea and some bacteria (particularly Gram-positive) have maximum activity in the absence of 2,3-bisphospho-D-glycerate. cf. EC 5.4.2.11.
  • The reaction involves a phosphotransferase reaction to serine followed by transfer back to the glycerate at the other position.
  • Both metal ions are involved in the reaction.
  • Formerly EC 2.7.5.3 and EC 5.4.2.1.
Cross-references
BRENDA5.4.2.12
EC2PDB5.4.2.12
ExplorEnz5.4.2.12
PRIAM enzyme-specific profiles5.4.2.12
KEGG Ligand Database for Enzyme Nomenclature5.4.2.12
IUBMB Enzyme Nomenclature5.4.2.12
IntEnz5.4.2.12
MEDLINEFind literature relating to 5.4.2.12
MetaCyc5.4.2.12
Rhea expert-curated reactions5.4.2.12
UniProtKB/Swiss-Prot
O28523, APGM1_ARCFUQ59007, APGM1_METJAO27628, APGM1_METTH
O28847, APGM2_ARCFUQ60326, APGM2_METJAO26518, APGM2_METTH
Q9YBI2, APGM_AERPEO66820, APGM_AQUAEQ1IW58, APGM_DEIGD
Q9RSA0, APGM_DEIRAQ74C57, APGM_GEOSLA8AC98, APGM_IGNH4
A6UTF2, APGM_META3P58812, APGM_METACQ46E58, APGM_METBF
Q12UL5, APGM_METBUP58813, APGM_METKAA2SR62, APGM_METLZ
A4FW85, APGM_METM5A9A9M4, APGM_METM6A6VH25, APGM_METM7
Q8PX04, APGM_METMAA3CSK8, APGM_METMJQ6LXB3, APGM_METMP
B8GFN7, APGM_METPEA5UKY4, APGM_METS3A4YIX4, APGM_METS5
Q2NES7, APGM_METSTA0B6L2, APGM_METTPA6UQ84, APGM_METVS
Q6KZJ6, APGM_PICTOQ9V2M6, APGM_PYRABQ8ZVE4, APGM_PYRAE
A4WL27, APGM_PYRARA3MWR8, APGM_PYRCJP58814, APGM_PYRFU
O57742, APGM_PYRHOA1RTD5, APGM_PYRILB1Y9H0, APGM_PYRNV
Q980A0, APGM_SACS2Q4JAH5, APGM_SULACC3MZ46, APGM_SULIA
C4KIC4, APGM_SULIKC3MQZ8, APGM_SULILC3MWY6, APGM_SULIM
C3NGG9, APGM_SULINC3N766, APGM_SULIYQ975P3, APGM_SULTO
B7IDT4, APGM_THEABQ9HL27, APGM_THEACC5A4S1, APGM_THEGJ
Q5JI21, APGM_THEKOA6LMV5, APGM_THEM4Q9X295, APGM_THEMA
B9K857, APGM_THENNA5ILK6, APGM_THEP1B1LAP9, APGM_THESQ
Q72GG0, APGM_THET2Q5SM27, APGM_THET8Q979H8, APGM_THEVO
Q8TMI6, GPMI1_METACQ46D52, GPMI1_METBFQ8TIY2, GPMI2_METAC
Q46AE4, GPMI2_METBFB0CA77, GPMI_ACAM1A3DBQ2, GPMI_ACET2
A9NF91, GPMI_ACHLIQ6FFD5, GPMI_ACIADA4ST23, GPMI_AERS4
Q8UAA5, GPMI_AGRFCB2UMU5, GPMI_AKKM8A8EW05, GPMI_ALIB4
Q5E8E9, GPMI_ALIF1B5FFX7, GPMI_ALIFMQ5PAE9, GPMI_ANAMM
Q2GKV7, GPMI_ANAPZQ06464, GPMI_ANTSPQ2NJ40, GPMI_AYWBP
A0RKS4, GPMI_BACAHQ81X77, GPMI_BACANQ72XY4, GPMI_BACC1
A7GUR8, GPMI_BACCNQ815K7, GPMI_BACCRQ631M1, GPMI_BACCZ
Q5LIL0, GPMI_BACFNQ64ZN5, GPMI_BACFRQ6HBF2, GPMI_BACHK
Q65EN1, GPMI_BACLDA8FHJ1, GPMI_BACP2P39773, GPMI_BACSU
Q8A287, GPMI_BACTNA7Z8Y2, GPMI_BACVZQ4VWF8, GPMI_BRUMA
G5EFZ1, GPMI_CAEELA8FKM1, GPMI_CAMJ8A7H4U3, GPMI_CAMJD
Q9PI71, GPMI_CAMJEA1VYF1, GPMI_CAMJJQ5HW32, GPMI_CAMJR
B3PGV8, GPMI_CELJUA3PMX9, GPMI_CERS1Q3IZB8, GPMI_CERS4
A4WWV3, GPMI_CERS5B9KN62, GPMI_CERSKA9WJ95, GPMI_CHLAA
B8GBF7, GPMI_CHLADB9LBA2, GPMI_CHLSYQ1R1J7, GPMI_CHRSD
Q7NSR8, GPMI_CHRVOQ97L53, GPMI_CLOABA7FQN9, GPMI_CLOB1
A6LR07, GPMI_CLOB8A7G9Y2, GPMI_CLOBLQ181T7, GPMI_CLOD6
A5N2N6, GPMI_CLOK5A0PYP3, GPMI_CLONNQ0TQY9, GPMI_CLOP1
Q8XKU2, GPMI_CLOPEQ0STD7, GPMI_CLOPSQ898R1, GPMI_CLOTE
Q47VY2, GPMI_COLP3A9KF70, GPMI_COXBNA9N970, GPMI_COXBR
Q83BH2, GPMI_COXBUA7MID1, GPMI_CROS8B8HVP2, GPMI_CYAP4
B1I0X9, GPMI_DESAPQ72BL6, GPMI_DESVHA8LKJ5, GPMI_DINSH
A7ZTG6, GPMI_ECO24Q8XDE9, GPMI_ECO57A8A677, GPMI_ECOHS
A1AHE9, GPMI_ECOK1Q0TBJ4, GPMI_ECOL5Q8FCA6, GPMI_ECOL6
B1IZH8, GPMI_ECOLCP37689, GPMI_ECOLIQ3YRU6, GPMI_EHRCJ
Q2GGW3, GPMI_EHRCRQ5FFL8, GPMI_EHRRGQ5HB16, GPMI_EHRRW
A4W533, GPMI_ENT38A5FJ26, GPMI_FLAJ1A6H1H2, GPMI_FLAPJ
B0TYM8, GPMI_FRAP2Q14GR4, GPMI_FRAT1A7NDJ7, GPMI_FRATF
Q2A2B1, GPMI_FRATHA0Q5M6, GPMI_FRATNQ0BKX8, GPMI_FRATO
Q5NFB1, GPMI_FRATTA4IZ68, GPMI_FRATWQ5KVE6, GPMI_GEOKA
Q9X519, GPMI_GEOSEQ747Q8, GPMI_GEOSLA4ISP5, GPMI_GEOTN
B7KGG1, GPMI_GLOC7Q7NMK9, GPMI_GLOVIQ5FU33, GPMI_GLUOX
Q6B8L5, GPMI_GRATLQ2SMA7, GPMI_HAHCHQ9K716, GPMI_HALH5
Q5UXB9, GPMI_HALMAB8CYG0, GPMI_HALOHQ9HNY7, GPMI_HALSA
Q18GK9, GPMI_HALWDQ17X03, GPMI_HELAHQ7VGZ8, GPMI_HELHP
Q1CSQ0, GPMI_HELPHQ9ZKM7, GPMI_HELPJP56196, GPMI_HELPY
A9AYE8, GPMI_HERA2Q31E77, GPMI_HYDCUQ5QZA9, GPMI_IDILO
Q1ISS4, GPMI_KORVEA9KPF4, GPMI_LACP7C1DDB1, GPMI_LARHH
Q1MPK8, GPMI_LAWIPQ5X7P2, GPMI_LEGPAA5IH96, GPMI_LEGPC
Q5ZY71, GPMI_LEGPHQ5WZ43, GPMI_LEGPLQ72VB8, GPMI_LEPIC
P59173, GPMI_LEPINQ928I2, GPMI_LISINQ71WX0, GPMI_LISMF
Q8Y4I4, GPMI_LISMOA0ALE0, GPMI_LISW6A0LDF3, GPMI_MAGMM
Q8EW33, GPMI_MALP2Q6F0W3, GPMI_MESFLQ5ZZU2, GPMI_MESH2
Q4A7D1, GPMI_MESH7Q4A992, GPMI_MESHJQ6KHV9, GPMI_MESM1
Q12UT0, GPMI_METBUQ1GZ82, GPMI_METFKQ6Y8Q8, GPMI_METH1
Q8PYF8, GPMI_METMAB0JLN5, GPMI_MICANQ2RLT9, GPMI_MOOTA
Q49006, GPMI_MYCCTQ7NAQ5, GPMI_MYCGAP47669, GPMI_MYCGE
Q6MSF0, GPMI_MYCMSP75167, GPMI_MYCPNQ98QA7, GPMI_MYCPU
Q4A5A8, GPMI_MYCS5Q1DCX8, GPMI_MYXXDQ3IS17, GPMI_NATPD
Q1XDA8, GPMI_NEOYEQ3JF23, GPMI_NITOCB2ITL6, GPMI_NOSP7
Q8YPL2, GPMI_NOSS1P59174, GPMI_OCEIHI6LDA6, GPMI_ONCVO
Q6YQT8, GPMI_ONYPEA6LFB1, GPMI_PARD8A1B4Z9, GPMI_PARDP
Q7U8U2, GPMI_PARMWQ6LVL2, GPMI_PHOPRA6L050, GPMI_PHOV8
P51379, GPMI_PORPUD5DVF4, GPMI_PRIM1D5DNA8, GPMI_PRIM3
A2C4I0, GPMI_PROM1A2C700, GPMI_PROM3Q7VA78, GPMI_PROMA
Q7V5U5, GPMI_PROMMQ7V051, GPMI_PROMPQ46J72, GPMI_PROMT
Q48C87, GPMI_PSE14Q15PS5, GPMI_PSEA6A6VDP9, GPMI_PSEA7
Q02EN5, GPMI_PSEABQ9HU53, GPMI_PSEAEQ1IG62, GPMI_PSEE4
Q4KJR8, GPMI_PSEF5A4Y077, GPMI_PSEMYA5WA89, GPMI_PSEP1
Q3KJH9, GPMI_PSEPFB0KN11, GPMI_PSEPGQ88CX4, GPMI_PSEPK
P52832, GPMI_PSESMQ3IIE4, GPMI_PSET1Q4ZLR0, GPMI_PSEU2
Q4FTU8, GPMI_PSYA2A1SZI3, GPMI_PSYINQ7UFG7, GPMI_RHOBA
Q6NCX7, GPMI_RHOPAB7K189, GPMI_RIPO1Q16D84, GPMI_ROSDO
Q5LLW1, GPMI_RUEPOQ1GCX7, GPMI_RUESTA1AXW7, GPMI_RUTMC
Q21NH1, GPMI_SACD2Q57IC9, GPMI_SALCHQ5PBZ2, GPMI_SALPA
A9MVK6, GPMI_SALPBQ2S026, GPMI_SALRDQ8Z2F0, GPMI_SALTI
Q8ZL56, GPMI_SALTYA8GLC2, GPMI_SERP5A1S1L6, GPMI_SHEAM
A3DAN0, GPMI_SHEB5A6WHC7, GPMI_SHEB8A9KUB8, GPMI_SHEB9
Q12HV5, GPMI_SHEDOQ07VW8, GPMI_SHEFNB0TLE6, GPMI_SHEHH
A3QJM4, GPMI_SHELPP59175, GPMI_SHEONA8HAE0, GPMI_SHEPA
A4Y1E3, GPMI_SHEPCA0KR77, GPMI_SHESAA8G1U9, GPMI_SHESH
Q0HP91, GPMI_SHESMQ0I0Q6, GPMI_SHESRA1RQ95, GPMI_SHESW
Q31V09, GPMI_SHIBSQ329P2, GPMI_SHIDSP59176, GPMI_SHIFL
Q3YVX7, GPMI_SHISSQ5WDK8, GPMI_SHOC1Q5HHP2, GPMI_STAAC
P64269, GPMI_STAAMP64270, GPMI_STAANQ6GIL5, GPMI_STAAR
Q6GB55, GPMI_STAASQ8NXL5, GPMI_STAAWQ5HQV1, GPMI_STAEQ
Q8CPY4, GPMI_STAESQ4L4K6, GPMI_STAHJQ49W02, GPMI_STAS1
Q9L214, GPMI_STRCOQ30Q40, GPMI_SULDNQ67SW0, GPMI_SYMTH
Q3A1E5, GPMI_SYNC1Q31R18, GPMI_SYNE7Q2JSV1, GPMI_SYNJA
Q2JIE9, GPMI_SYNJBB1XJ47, GPMI_SYNP2Q5N381, GPMI_SYNP6
P74507, GPMI_SYNY3B9KYT9, GPMI_THERPP59177, GPMI_THEVB
Q3SGA3, GPMI_THIDAQ8L2S1, GPMI_TOBBPQ117D6, GPMI_TRIEI
Q3MF89, GPMI_TRIV2B1AIH0, GPMI_UREP2Q9PQW1, GPMI_UREPA
B5ZAY8, GPMI_UREU1A5CVF0, GPMI_VESOHB7VHQ4, GPMI_VIBA3
A7MX70, GPMI_VIBC1A5F3N4, GPMI_VIBC3Q9KV22, GPMI_VIBCH
C3LR68, GPMI_VIBCMQ87KZ5, GPMI_VIBPAQ8DCW1, GPMI_VIBVU
Q7MGZ2, GPMI_VIBVYQ73GR4, GPMI_WOLPMQ7M7W9, GPMI_WOLSU
Q5GSN3, GPMI_WOLTRA1JHY1, GPMI_YERE8A7FCU8, GPMI_YERP3
Q1C282, GPMI_YERPAQ8ZJN0, GPMI_YERPEQ1CD17, GPMI_YERPN
A4TSC2, GPMI_YERPPQ66GC2, GPMI_YERPSQ79FW5, PG11_MYCTU
Q38AH1, PGAMI_TRYB2O04499, PMG1_ARATHQ9M9K1, PMG2_ARATH
P30792, PMGI_MAIZEQ42908, PMGI_MESCRO24246, PMGI_PRUDU
P35493, PMGI_RICCOP35494, PMGI_TOBAC

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-