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ENZYME

ENZYME entry: EC 5.4.2.2

Accepted Name
phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
Alternative Name(s)
glucose phosphomutase
phosphoglucose mutase
Reaction catalysed
alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate
Comment(s)
  • Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate.
  • This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization.
  • Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. cf. EC 5.4.2.5.
  • Formerly EC 2.7.5.1.
Cross-references
BRENDA5.4.2.2
EC2PDB5.4.2.2
ExplorEnz5.4.2.2
PRIAM enzyme-specific profiles5.4.2.2
KEGG Ligand Database for Enzyme Nomenclature5.4.2.2
IUBMB Enzyme Nomenclature5.4.2.2
IntEnz5.4.2.2
MEDLINEFind literature relating to 5.4.2.2
MetaCyc5.4.2.2
Rhea expert-curated reactions5.4.2.2
UniProtKB/Swiss-Prot
Q02E40, ALGC_PSEABP26276, ALGC_PSEAEQ88C93, ALGC_PSEPK
Q88BD4, ALGC_PSESMP18159, PGCA_BACSUQ2FE11, PGCA_STAA3
Q2FVC1, PGCA_STAA8Q2YW66, PGCA_STAABQ5HD61, PGCA_STAAC
Q99RE2, PGCA_STAAMQ7A3K7, PGCA_STAANQ6GDU9, PGCA_STAAR
Q6G6I3, PGCA_STAASQ8NUV4, PGCA_STAAWQ5HLD2, PGCA_STAEQ
Q8CN38, PGCA_STAESQ4L9R5, PGCA_STAHJQ49WH7, PGCA_STAS1
Q08DP0, PGM1_BOVINQ23919, PGM1_DICDIP36871, PGM1_HUMAN
Q4R5E4, PGM1_MACFAQ9D0F9, PGM1_MOUSEP47244, PGM1_PARTE
P00949, PGM1_RABITP38652, PGM1_RATP33401, PGM1_YEAST
Q54UQ2, PGM2_DICDIQ96G03, PGM2_HUMANQ7TSV4, PGM2_MOUSE
O02606, PGM2_PARTEQ5RFI8, PGM2_PONABP37012, PGM2_YEAST
O49299, PGMC1_ARATHP93804, PGMC1_MAIZEQ9SGC1, PGMC2_ARATH
P93805, PGMC2_MAIZEQ9SNX2, PGMC_BROINP93262, PGMC_MESCR
Q9SM60, PGMC_PEAQ9ZSQ4, PGMC_POPTNQ9M4G4, PGMC_SOLTU
Q68BJ6, PGMMM_THEKOA0A2R6W0K6, PGMP1_MARPOQ9SCY0, PGMP_ARATH
Q9SMM0, PGMP_BRANAQ9SM59, PGMP_PEAQ9M4G5, PGMP_SOLTU
Q4WY53, PGM_ASPFUP57749, PGM_ASPORQ9VUY9, PGM_DROME
P36938, PGM_ECOLIQ9P931, PGM_EMENIO18719, PGM_ENTDI
O15820, PGM_ENTH1P38569, PGM_KOMXYP40390, PGM_NEIGO
P57002, PGM_NEIMAP40391, PGM_NEIMBP39671, PGM_RHIRD
O74374, PGM_SCHPOB0RVK5, XANA_XANCBP0C7J2, XANA_XANCP

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