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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 5.6.1.1

Accepted Name
Microtubule-severing ATPase.
Alternative Name(s)
Katanin.
Reaction catalysed
n ATP + n H(2)O + a microtubule <=> n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers
Comment(s)
  • A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
  • Formerly EC 3.6.4.3.
Cross-references
PROSITEPDOC00572
BRENDA5.6.1.1
EC2PDB5.6.1.1
ExplorEnz5.6.1.1
PRIAM enzyme-specific profiles5.6.1.1
KEGG Ligand Database for Enzyme Nomenclature5.6.1.1
IUBMB Enzyme Nomenclature5.6.1.1
IntEnz5.6.1.1
MEDLINEFind literature relating to 5.6.1.1
MetaCyc5.6.1.1
UniProtKB/Swiss-Prot
Q5U3S1, KATL1_DANRE;  Q9BW62, KATL1_HUMAN;  Q8K0T4, KATL1_MOUSE;  
B4USW8, KATL1_OTOGA;  A9RA82, KATL1_PAPAN;  B7NZ88, KATL1_RABIT;  
Q5XIK7, KATL1_RAT;  B3EX35, KATL1_SORAR;  Q8IYT4, KATL2_HUMAN;  
Q9D3R6, KATL2_MOUSE;  Q3B8D5, KATL2_XENLA;  A0JMA9, KATL2_XENTR;  
Q9SEX2, KTNA1_ARATH;  P34808, KTNA1_CAEEL;  Q1HGK7, KTNA1_CHICK;  
Q5RII9, KTNA1_DANRE;  O75449, KTNA1_HUMAN;  Q4R407, KTNA1_MACFA;  
Q9WV86, KTNA1_MOUSE;  Q6E0V2, KTNA1_RAT;  B5X3X5, KTNA1_SALSA;  
O61577, KTNA1_STRPU;  Q9PUL2, KTNA1_XENLA;  Q0IIR9, KTNA1_XENTR;  
Q7QBW0, SPAST_ANOGA;  A2VDN5, SPAST_BOVIN;  A8QFF6, SPAST_BRUMA;  
A8XV40, SPAST_CAEBR;  Q8MNV0, SPAST_CAEEL;  Q5ZK92, SPAST_CHICK;  
Q6NW58, SPAST_DANRE;  Q54KQ7, SPAST_DICDI;  B3M301, SPAST_DROAN;  
B3P8A3, SPAST_DROER;  B4JII0, SPAST_DROGR;  Q8I0P1, SPAST_DROME;  
B4K799, SPAST_DROMO;  B4G437, SPAST_DROPE;  Q298L4, SPAST_DROPS;  
B4HGG6, SPAST_DROSE;  B4QSF0, SPAST_DROSI;  B4M0H8, SPAST_DROVI;  
B4NBP4, SPAST_DROWI;  B4PL32, SPAST_DROYA;  Q9UBP0, SPAST_HUMAN;  
B7PXE3, SPAST_IXOSC;  Q9QYY8, SPAST_MOUSE;  A7T395, SPAST_NEMVE;  
Q719N1, SPAST_PIG;  B2RYN7, SPAST_RAT;  Q6AZT2, SPAST_XENLA;  
Q05AS3, SPAST_XENTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-