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ENZYME entry: EC 5.6.1.2

Accepted Name
Dynein ATPase.
Alternative Name(s)
Dynein adenosine 5'-triphosphatase.
Reaction catalysed
ATP + H(2)O + a dynein associated with a microtubule at position (n) <=> ADP + phosphate + a dynein associated with a microtubule at position (n-1, toward the minus end)
Comment(s)
  • A multisubunit protein complex associated with microtubules.
  • Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome toward the microtubule's minus end.
  • It also functions in the movement of eukaryotic flagella and cilia.
  • It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).
  • Formerly EC 3.6.1.33 AND EC 3.6.4.2.
Cross-references
BRENDA5.6.1.2
EC2PDB5.6.1.2
ExplorEnz5.6.1.2
PRIAM enzyme-specific profiles5.6.1.2
KEGG Ligand Database for Enzyme Nomenclature5.6.1.2
IUBMB Enzyme Nomenclature5.6.1.2
IntEnz5.6.1.2
MEDLINEFind literature relating to 5.6.1.2
MetaCyc5.6.1.2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-