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ENZYME

ENZYME entry: EC 5.6.2.1

Accepted Name
DNA topoisomerase
Alternative Name(s)
DNA topoisomerase I
nicking-closing enzyme
omega-protein
relaxing enzyme
swivelase
type I DNA topoisomerase
untwisting enzyme
Reaction catalysed
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Comment(s)
  • These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.2.
  • Formerly EC 5.99.1.2.
Cross-references
BRENDA5.6.2.1
EC2PDB5.6.2.1
ExplorEnz5.6.2.1
PRIAM enzyme-specific profiles5.6.2.1
KEGG Ligand Database for Enzyme Nomenclature5.6.2.1
IUBMB Enzyme Nomenclature5.6.2.1
IntEnz5.6.2.1
MEDLINEFind literature relating to 5.6.2.1
MetaCyc5.6.2.1
Rhea expert-curated reactions5.6.2.1
UniProtKB/Swiss-Prot
P13658, MBEA_ECOLXP07112, MOBA2_ECOLXP30181, TOP1A_ARATH
Q9FJ79, TOP1B_ARATHQ7T6X9, TOP1E_MIMIVQ969P6, TOP1M_HUMAN
Q8R4U6, TOP1M_MOUSEA9Q1D5, TOP1M_PANTRQ6IM78, TOP1M_RAT
Q5UQB5, TOP1P_MIMIVQ9PHK2, TOP1P_XYLFAQ9YB01, TOP1_AERPE
P34184, TOP1_ALKPOO66893, TOP1_AQUAEO28469, TOP1_ARCFU
P40114, TOP1_BACANP39814, TOP1_BACSUO51768, TOP1_BORBU
P57371, TOP1_BUCAIQ8K9P7, TOP1_BUCAPO17966, TOP1_CAEEL
Q9PLZ2, TOP1_CAMJEA0A0L0P4F8, TOP1_CANARQ00313, TOP1_CANAX
Q7YR26, TOP1_CHLAEQ07050, TOP1_CRIGRP93119, TOP1_DAUCA
Q54RC3, TOP1_DICDIP30189, TOP1_DROMEP06612, TOP1_ECOLI
O34204, TOP1_FERISP43012, TOP1_HAEINQ9KA23, TOP1_HALH5
Q9ZMV7, TOP1_HELPJP55991, TOP1_HELPYP11387, TOP1_HUMAN
P46155, TOP1_KLEAEQ9CG80, TOP1_LACLAQ59046, TOP1_METJA
O27661, TOP1_METTHA0A7H0DN83, TOP1_MONPVQ04750, TOP1_MOUSE
P0A621, TOP1_MYCBOQ9JN65, TOP1_MYCGAP47368, TOP1_MYCGE
O69548, TOP1_MYCLEP78032, TOP1_MYCPNA0R5D9, TOP1_MYCS2
A5U8X0, TOP1_MYCTAP9WG48, TOP1_MYCTOP9WG49, TOP1_MYCTU
Q9CN30, TOP1_PASMUQ9HZJ5, TOP1_PSEAEQ9UYS8, TOP1_PYRAB
O73954, TOP1_PYRFUO58356, TOP1_PYRHOQ9WUL0, TOP1_RAT
P16472, TOP1_RFVKAQ1RIM1, TOP1_RICBRQ92IH1, TOP1_RICCN
Q4UM42, TOP1_RICFEQ9ZDK2, TOP1_RICPRQ68X45, TOP1_RICTY
P0A2I2, TOP1_SALTIP0A2I1, TOP1_SALTYP07799, TOP1_SCHPO
Q2FHI8, TOP1_STAA3Q2FZ32, TOP1_STAA8Q2YXL8, TOP1_STAAB
Q5HGI2, TOP1_STAACQ99UM1, TOP1_STAAMQ7A5Y5, TOP1_STAAN
Q6GHI5, TOP1_STAARQ6G9W3, TOP1_STAASQ06AK7, TOP1_STAAU
Q8NWZ9, TOP1_STAAWQ5HPU2, TOP1_STAEQQ8CSU3, TOP1_STAES
Q4L5V2, TOP1_STAHJQ49X35, TOP1_STAS1Q9X909, TOP1_STRCO
P34185, TOP1_SYNE7P73810, TOP1_SYNY3Q9HM08, TOP1_THEAC
P46799, TOP1_THEMAO83409, TOP1_TREPAP41511, TOP1_USTMA
Q76ZS7, TOP1_VACCAP68697, TOP1_VACCCP68698, TOP1_VACCW
P32989, TOP1_VAR67Q9KRB2, TOP1_VIBCHP41512, TOP1_XENLA
Q9PEV8, TOP1_XYLFAQ87AQ6, TOP1_XYLFTP04786, TOP1_YEAST
Q9X3X7, TOP1_ZYMMOQ9LVP1, TOP3A_ARATHQ9NG98, TOP3A_DROME
Q13472, TOP3A_HUMANO70157, TOP3A_MOUSEC7J0A2, TOP3A_ORYSJ
F4ISQ7, TOP3B_ARATHO96651, TOP3B_DROMEO95985, TOP3B_HUMAN
Q9Z321, TOP3B_MOUSEQ0J0S6, TOP3B_ORYSJQ5WAX6, TOP3_ALKCK
A0R979, TOP3_BACAHQ81Z97, TOP3_BACANQ73E74, TOP3_BACC1
Q81IH1, TOP3_BACCRQ63GK5, TOP3_BACCZQ6HP19, TOP3_BACHK
Q65N90, TOP3_BACLDP96583, TOP3_BACSUO61660, TOP3_CAEEL
A0A0L0P6P7, TOP3_CANARQ8T2T7, TOP3_DICDIP14294, TOP3_ECOLI
P43704, TOP3_HAEINQ9CP53, TOP3_PASMUQ8Z6F5, TOP3_SALTI
P40687, TOP3_SALTYO60126, TOP3_SCHPOQ2FEN5, TOP3_STAA3
Q2FW03, TOP3_STAA8P0C2W6, TOP3_STAABQ5HDV4, TOP3_STAAC
Q99S17, TOP3_STAAMQ7A455, TOP3_STAANQ6GEH9, TOP3_STAAR
Q6G767, TOP3_STAASQ7A075, TOP3_STAAWQ5HLZ4, TOP3_STAEQ
Q8CRF7, TOP3_STAESQ4L8B8, TOP3_STAHJQ49ZH2, TOP3_STAS1
Q9KQF5, TOP3_VIBCHP13099, TOP3_YEASTP14565, TRAI1_ECOLI
P22706, TRAI2_ECOLX

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-