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ENZYME

ENZYME entry: EC 5.6.2.1

PURL: https://purl.expasy.org/enzyme/EC/5.6.2.1
Accepted Name
DNA topoisomerase
Alternative Name(s)
DNA topoisomerase I
nicking-closing enzyme
omega-protein
relaxing enzyme
swivelase
type I DNA topoisomerase
untwisting enzyme
Reaction catalysed
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Comment(s)
  • These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.2.
  • Formerly EC 5.99.1.2.
Cross-references
BRENDA5.6.2.1
EC2PDB5.6.2.1
ExplorEnz5.6.2.1
KEGG Ligand Database for Enzyme Nomenclature5.6.2.1
IUBMB Enzyme Nomenclature5.6.2.1
MEDLINEFind literature relating to 5.6.2.1
MetaCyc5.6.2.1
Rhea expert-curated reactions5.6.2.1
UniProtKB/Swiss-Prot
P13658, MBEA_ECOLXP07112, MOBA2_ECOLXP30181, TOP1A_ARATH
Q9FJ79, TOP1B_ARATHQ7T6X9, TOP1E_MIMIVQ969P6, TOP1M_HUMAN
Q8R4U6, TOP1M_MOUSEA9Q1D5, TOP1M_PANTRQ6IM78, TOP1M_RAT
Q5UQB5, TOP1P_MIMIVQ9PHK2, TOP1P_XYLFAQ9YB01, TOP1_AERPE
P34184, TOP1_ALKPOO66893, TOP1_AQUAEO28469, TOP1_ARCFU
P40114, TOP1_BACANP39814, TOP1_BACSUO51768, TOP1_BORBU
P57371, TOP1_BUCAIQ8K9P7, TOP1_BUCAPO17966, TOP1_CAEEL
Q9PLZ2, TOP1_CAMJEA0A0L0P4F8, TOP1_CANARQ00313, TOP1_CANAX
Q7YR26, TOP1_CHLAEQ07050, TOP1_CRIGRP93119, TOP1_DAUCA
Q54RC3, TOP1_DICDIP30189, TOP1_DROMEP06612, TOP1_ECOLI
O34204, TOP1_FERISP43012, TOP1_HAEINQ9KA23, TOP1_HALH5
Q9ZMV7, TOP1_HELPJP55991, TOP1_HELPYP11387, TOP1_HUMAN
P46155, TOP1_KLEAEQ9CG80, TOP1_LACLAQ59046, TOP1_METJA
O27661, TOP1_METTHA0A7H0DN83, TOP1_MONPVQ04750, TOP1_MOUSE
P0A621, TOP1_MYCBOQ9JN65, TOP1_MYCGAP47368, TOP1_MYCGE
O69548, TOP1_MYCLEP41511, TOP1_MYCMDP78032, TOP1_MYCPN
A0R5D9, TOP1_MYCS2A5U8X0, TOP1_MYCTAP9WG48, TOP1_MYCTO
P9WG49, TOP1_MYCTUQ9CN30, TOP1_PASMUQ9HZJ5, TOP1_PSEAE
Q9UYS8, TOP1_PYRABO73954, TOP1_PYRFUO58356, TOP1_PYRHO
Q9WUL0, TOP1_RATP16472, TOP1_RFVKAQ1RIM1, TOP1_RICBR
Q92IH1, TOP1_RICCNQ4UM42, TOP1_RICFEQ9ZDK2, TOP1_RICPR
Q68X45, TOP1_RICTYP0A2I2, TOP1_SALTIP0A2I1, TOP1_SALTY
P07799, TOP1_SCHPOQ2FHI8, TOP1_STAA3Q2FZ32, TOP1_STAA8
Q2YXL8, TOP1_STAABQ5HGI2, TOP1_STAACQ99UM1, TOP1_STAAM
Q7A5Y5, TOP1_STAANQ6GHI5, TOP1_STAARQ6G9W3, TOP1_STAAS
Q06AK7, TOP1_STAAUQ8NWZ9, TOP1_STAAWQ5HPU2, TOP1_STAEQ
Q8CSU3, TOP1_STAESQ4L5V2, TOP1_STAHJQ49X35, TOP1_STAS1
Q9X909, TOP1_STRCOP34185, TOP1_SYNE7P73810, TOP1_SYNY3
Q9HM08, TOP1_THEACP46799, TOP1_THEMAO83409, TOP1_TREPA
Q76ZS7, TOP1_VACCAP68697, TOP1_VACCCP68698, TOP1_VACCW
P32989, TOP1_VAR67Q9KRB2, TOP1_VIBCHP41512, TOP1_XENLA
Q9PEV8, TOP1_XYLFAQ87AQ6, TOP1_XYLFTP04786, TOP1_YEAST
Q9X3X7, TOP1_ZYMMOQ9LVP1, TOP3A_ARATHQ9NG98, TOP3A_DROME
Q13472, TOP3A_HUMANO70157, TOP3A_MOUSEC7J0A2, TOP3A_ORYSJ
F4ISQ7, TOP3B_ARATHO96651, TOP3B_DROMEO95985, TOP3B_HUMAN
Q9Z321, TOP3B_MOUSEQ0J0S6, TOP3B_ORYSJA0R979, TOP3_BACAH
Q81Z97, TOP3_BACANQ73E74, TOP3_BACC1Q81IH1, TOP3_BACCR
Q63GK5, TOP3_BACCZQ6HP19, TOP3_BACHKQ65N90, TOP3_BACLD
P96583, TOP3_BACSUO61660, TOP3_CAEELA0A0L0P6P7, TOP3_CANAR
Q8T2T7, TOP3_DICDIP14294, TOP3_ECOLIP43704, TOP3_HAEIN
Q9CP53, TOP3_PASMUQ97ZJ8, TOP3_SACS2Q8Z6F5, TOP3_SALTI
P40687, TOP3_SALTYO60126, TOP3_SCHPOQ5WAX6, TOP3_SHOC1
Q2FEN5, TOP3_STAA3Q2FW03, TOP3_STAA8P0C2W6, TOP3_STAAB
Q5HDV4, TOP3_STAACQ99S17, TOP3_STAAMQ7A455, TOP3_STAAN
Q6GEH9, TOP3_STAARQ6G767, TOP3_STAASQ7A075, TOP3_STAAW
Q5HLZ4, TOP3_STAEQQ8CRF7, TOP3_STAESQ4L8B8, TOP3_STAHJ
Q49ZH2, TOP3_STAS1Q9KQF5, TOP3_VIBCHP13099, TOP3_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-