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ENZYME

ENZYME entry: EC 6.2.1.2

PURL: https://purl.expasy.org/enzyme/EC/6.2.1.2
Accepted Name
medium-chain acyl-CoA ligase
Alternative Name(s)
acyl-activating enzyme
butyryl-CoA synthetase
fatty acid thiokinase (medium chain)
Reaction catalysed
a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate
Comment(s)
  • Acts on fatty acids from C4 to C11 and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids.
  • The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
Cross-references
BRENDA6.2.1.2
EC2PDB6.2.1.2
ExplorEnz6.2.1.2
KEGG Ligand Database for Enzyme Nomenclature6.2.1.2
IUBMB Enzyme Nomenclature6.2.1.2
MEDLINEFind literature relating to 6.2.1.2
MetaCyc6.2.1.2
Rhea expert-curated reactions6.2.1.2
UniProtKB/Swiss-Prot
Q9C8D4, AAE11_ARATHQ08AH3, ACS2A_HUMANQ68CK6, ACS2B_HUMAN
Q17QJ1, ACSF2_BOVINQ0P4F7, ACSF2_DANREQ96CM8, ACSF2_HUMAN
Q4R4Z9, ACSF2_MACFAQ8VCW8, ACSF2_MOUSEQ5R9G9, ACSF2_PONAB
Q499N5, ACSF2_RATO95573, ACSL3_HUMANQ9CZW4, ACSL3_MOUSE
Q5R668, ACSL3_PONABQ63151, ACSL3_RATQ9BEA2, ACSM1_BOVIN
Q08AH1, ACSM1_HUMANQ91VA0, ACSM1_MOUSEQ8K0L3, ACSM2_MOUSE
O70490, ACSM2_RATQ53FZ2, ACSM3_HUMANQ3UNX5, ACSM3_MOUSE
Q5REV5, ACSM3_PONABQ6SKG1, ACSM3_RATP0C7M7, ACSM4_HUMAN
Q80W40, ACSM4_MOUSEQ7TN78, ACSM4_RATQ6NUN0, ACSM5_HUMAN
Q8BGA8, ACSM5_MOUSEQ6AYT9, ACSM5_RATQ6P461, ACSM6_HUMAN
Q8VZF1, AEE7_ARATHQ00594, ALKK_ECTOLQ7TWC5, FAC17_MYCBO
B2HHZ8, FAC17_MYCMMO53551, FAC17_MYCTUQ7TWB7, FAC19_MYCBO
B2HI05, FAC19_MYCMMA0R4Q2, FAC19_MYCS2P9WQ50, FAC19_MYCTO
P9WQ51, FAC19_MYCTUO05307, FAC6_MYCTUO06417, FAC8_MYCTU
A4YDT1, HBCL1_METS5A4YDR9, HBCL2_METS5O33855, MIG_MYCAV

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-