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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 6.2.1.2

Accepted Name
Medium-chain acyl-CoA ligase.
Alternative Name(s)
Acyl-activating enzyme.
Butyryl-CoA synthetase.
Fatty acid thiokinase (medium chain).
Reaction catalysed
ATP + a medium-chain fatty acid + CoA <=> AMP + diphosphate + a medium-chain acyl-CoA
Comment(s)
  • Acts on fatty acids from C(4) to C(11) and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids.
  • The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
Cross-references
BRENDA6.2.1.2
EC2PDB6.2.1.2
ExplorEnz6.2.1.2
PRIAM enzyme-specific profiles6.2.1.2
KEGG Ligand Database for Enzyme Nomenclature6.2.1.2
IUBMB Enzyme Nomenclature6.2.1.2
IntEnz6.2.1.2
MEDLINEFind literature relating to 6.2.1.2
MetaCyc6.2.1.2
UniProtKB/Swiss-Prot
Q9C8D4, AAE11_ARATH;  Q08AH3, ACS2A_HUMAN;  Q68CK6, ACS2B_HUMAN;  
Q9BEA2, ACSM1_BOVIN;  Q08AH1, ACSM1_HUMAN;  Q91VA0, ACSM1_MOUSE;  
Q8K0L3, ACSM2_MOUSE;  O70490, ACSM2_RAT;  Q53FZ2, ACSM3_HUMAN;  
Q3UNX5, ACSM3_MOUSE;  Q5REV5, ACSM3_PONAB;  Q6SKG1, ACSM3_RAT;  
P0C7M7, ACSM4_HUMAN;  Q80W40, ACSM4_MOUSE;  Q7TN78, ACSM4_RAT;  
Q6NUN0, ACSM5_HUMAN;  Q8BGA8, ACSM5_MOUSE;  Q6AYT9, ACSM5_RAT;  
Q6P461, ACSM6_HUMAN;  Q8VZF1, AEE7_ARATH;  A4YDT1, HBCL1_METS5;  
A4YDR9, HBCL2_METS5;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-