A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
Ligases
The following ENZYME entries belong to class 6.-.-.-:
6.1.1.1 Tyrosine--tRNA ligase 6.1.1.2 Tryptophan--tRNA ligase 6.1.1.3 Threonine--tRNA ligase 6.1.1.4 Leucine--tRNA ligase 6.1.1.5 Isoleucine--tRNA ligase 6.1.1.6 Lysine--tRNA ligase 6.1.1.7 Alanine--tRNA ligase 6.1.1.8 Deleted entry 6.1.1.9 Valine--tRNA ligase 6.1.1.10 Methionine--tRNA ligase 6.1.1.11 Serine--tRNA ligase 6.1.1.12 Aspartate--tRNA ligase 6.1.1.13 D-alanine--poly(phosphoribitol) ligase 6.1.1.14 Glycine--tRNA ligase 6.1.1.15 Proline--tRNA ligase 6.1.1.16 Cysteine--tRNA ligase 6.1.1.17 Glutamate--tRNA ligase 6.1.1.18 Glutamine--tRNA ligase 6.1.1.19 Arginine--tRNA ligase 6.1.1.20 Phenylalanine--tRNA ligase 6.1.1.21 Histidine--tRNA ligase 6.1.1.22 Asparagine--tRNA ligase 6.1.1.23 Aspartate--tRNA(Asn) ligase 6.1.1.24 Glutamate--tRNA(Gln) ligase 6.1.1.25 Deleted entry 6.1.1.26 Pyrrolysine--tRNA(Pyl) ligase 6.1.1.27 O-phosphoserine--tRNA ligase 6.1.1.28 Deleted entry 6.1.1.n1 Transferred entry: 6.3.1.13 6.1.1.n2 Transferred entry: 6.1.1.27 6.1.2.1 D-alanine--(R)-lactate ligase 6.1.2.2 Nebramycin 5' synthase 6.1.3.1 Olefin beta-lactone synthetase 6.2.1.1 Acetate--CoA ligase 6.2.1.2 Medium-chain acyl-CoA ligase 6.2.1.3 Long-chain-fatty-acid--CoA ligase 6.2.1.4 Succinate--CoA ligase (GDP-forming) 6.2.1.5 Succinate--CoA ligase (ADP-forming) 6.2.1.6 Glutarate--CoA ligase 6.2.1.7 Cholate--CoA ligase 6.2.1.8 Oxalate--CoA ligase 6.2.1.9 Malate--CoA ligase 6.2.1.10 Acid--CoA ligase (GDP-forming) 6.2.1.11 Biotin--CoA ligase 6.2.1.12 4-coumarate--CoA ligase 6.2.1.13 Acetate--CoA ligase (ADP-forming) 6.2.1.14 6-carboxyhexanoate--CoA ligase 6.2.1.15 Arachidonate--CoA ligase 6.2.1.16 Acetoacetate--CoA ligase 6.2.1.17 Propionate--CoA ligase 6.2.1.18 Citrate--CoA ligase 6.2.1.19 Long-chain-fatty-acid--protein ligase 6.2.1.20 Long-chain-fatty-acid--[acyl-carrier-protein] ligase 6.2.1.21 Transferred entry: 6.2.1.30 6.2.1.22 [Citrate (pro-3S)-lyase] ligase 6.2.1.23 Dicarboxylate--CoA ligase 6.2.1.24 Phytanate--CoA ligase 6.2.1.25 Benzoate--CoA ligase 6.2.1.26 o-succinylbenzoate--CoA ligase 6.2.1.27 4-hydroxybenzoate--CoA ligase 6.2.1.28 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate--CoA ligase 6.2.1.29 Transferred entry: 6.2.1.7 6.2.1.30 Phenylacetate--CoA ligase 6.2.1.31 2-furoate--CoA ligase 6.2.1.32 Anthranilate--CoA ligase 6.2.1.33 4-chlorobenzoate--CoA ligase 6.2.1.34 Trans-feruloyl-CoA synthase 6.2.1.35 Acetate--[acyl-carrier protein] ligase 6.2.1.36 3-hydroxypropionyl-CoA synthase 6.2.1.37 3-hydroxybenzoate--CoA ligase 6.2.1.38 (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase 6.2.1.39 [Butirosin acyl-carrier protein]--L-glutamate ligase 6.2.1.40 4-hydroxybutyrate--CoA ligase 6.2.1.41 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate- -CoA ligase 6.2.1.42 3-oxocholest-4-en-26-oate--CoA ligase 6.2.1.43 2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase 6.2.1.44 3-(methylthio)propionyl--CoA ligase 6.2.1.45 E1 ubiquitin-activating enzyme 6.2.1.46 L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase 6.2.1.47 Medium-chain-fatty-acid--(acyl-carrier-protein) ligase 6.2.1.48 Carnitine--CoA ligase 6.2.1.49 Long-chain fatty acid adenylyltransferase FadD28 6.2.1.50 4-hydroxybenzoate adenylyltransferase FadD22 6.2.1.51 4-hydroxyphenylalkanoate adenylyltransferase FadD29 6.2.1.52 L-firefly luciferin--CoA ligase 6.2.1.53 L-proline--[L-prolyl-carrier protein] ligase 6.2.1.54 D-alanine--[D-alanyl-carrier protein] ligase 6.2.1.55 E1 SAMP-activating enzyme 6.2.1.n1 Transferred entry: 6.2.1.37 6.2.1.n2 Amino acid--[acyl-carrier-protein] ligase 6.2.1.n3 Malonate--CoA ligase 6.3.1.1 Aspartate--ammonia ligase 6.3.1.2 Glutamine synthetase 6.3.1.3 Transferred entry: 6.3.4.13 6.3.1.4 Aspartate--ammonia ligase (ADP-forming) 6.3.1.5 NAD(+) synthase 6.3.1.6 Glutamate--ethylamine ligase 6.3.1.7 4-methyleneglutamate--ammonia ligase 6.3.1.8 Glutathionylspermidine synthase 6.3.1.9 Trypanothione synthase 6.3.1.10 Adenosylcobinamide-phosphate synthase 6.3.1.11 Glutamate--putrescine ligase 6.3.1.12 D-aspartate ligase 6.3.1.13 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase 6.3.1.14 Diphthine--ammonia ligase 6.3.1.15 8-demethylnovobiocic acid synthase 6.3.1.16 Transferred entry: 6.3.3.6 6.3.1.17 Beta-citrylglutamate synthase 6.3.1.18 Gamma-glutamylanilide synthase 6.3.1.19 Prokaryotic ubiquitin-like protein ligase 6.3.1.20 Lipoate--protein ligase 6.3.2.1 Pantoate--beta-alanine ligase (AMP-forming) 6.3.2.2 Glutamate--cysteine ligase 6.3.2.3 Glutathione synthase 6.3.2.4 D-alanine--D-alanine ligase 6.3.2.5 Phosphopantothenate--cysteine ligase (CTP) 6.3.2.6 Phosphoribosylaminoimidazolesuccinocarboxamide synthase 6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase 6.3.2.8 UDP-N-acetylmuramate--L-alanine ligase 6.3.2.9 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase 6.3.2.10 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 6.3.2.11 Carnosine synthase 6.3.2.12 Dihydrofolate synthase 6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 6.3.2.14 Enterobactin synthase 6.3.2.15 Transferred entry: 6.3.2.10 6.3.2.16 D-alanine--alanyl-poly(glycerolphosphate) ligase 6.3.2.17 Tetrahydrofolate synthase 6.3.2.18 Gamma-glutamylhistamine synthase 6.3.2.19 Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45 6.3.2.20 Indoleacetate--lysine synthetase 6.3.2.21 Transferred entry: 2.3.2.27 and 6.2.1.45 6.3.2.22 Transferred entry: 6.3.1.14 6.3.2.23 Homoglutathione synthase 6.3.2.24 Tyrosine--arginine ligase 6.3.2.25 Tubulin--tyrosine ligase 6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase 6.3.2.27 Transferred entry: 6.3.2.38 and 6.3.2.39 6.3.2.28 Transferred entry: 6.3.2.49 6.3.2.29 Cyanophycin synthase (L-aspartate-adding) 6.3.2.30 Cyanophycin synthase (L-arginine-adding) 6.3.2.31 Coenzyme F420-0:L-glutamate ligase 6.3.2.32 Coenzyme gamma-F420-2:alpha-L-glutamate ligase 6.3.2.33 Tetrahydrosarcinapterin synthase 6.3.2.34 Coenzyme F420-1:gamma-L-glutamate ligase 6.3.2.35 D-alanine--D-serine ligase 6.3.2.36 4-phosphopantoate--beta-alanine ligase 6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase 6.3.2.38 N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase 6.3.2.39 Aerobactin synthase 6.3.2.40 Cyclopeptine synthase 6.3.2.41 N-acetylaspartylglutamate synthase 6.3.2.42 N-acetylaspartylglutamylglutamate synthase 6.3.2.43 [Lysine-biosynthesis-protein LysW]--L-2-aminoadipate ligase 6.3.2.44 Pantoate--beta-alanine ligase (ADP-forming) 6.3.2.45 UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate ligase 6.3.2.46 Fumarate--(S)-2,3-diaminopropanoate ligase 6.3.2.47 Dapdiamide synthase 6.3.2.48 L-arginine-specific L-amino acid ligase 6.3.2.49 L-alanine--L-anticapsin ligase 6.3.2.50 Tenuazonic acid synthetase 6.3.2.51 Phosphopantothenate--cysteine ligase (ATP) 6.3.2.52 Jasmonoyl--L-amino acid synthetase 6.3.2.n1 Transferred entry: 6.3.2.37 6.3.2.n2 Transferred entry: 6.3.1.19 6.3.2.n3 ISG15--protein ligase 6.3.2.n4 Transferred entry: 6.3.2.43 6.3.2.n5 Transferred entry: 6.3.2.44 6.3.2.n6 Transferred entry: 6.3.2.41 6.3.3.1 Phosphoribosylformylglycinamidine cyclo-ligase 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase 6.3.3.3 Dethiobiotin synthase 6.3.3.4 (Carboxyethyl)arginine beta-lactam-synthase 6.3.3.5 O-ureido-D-serine cyclo-ligase 6.3.3.6 Carbapenam-3-carboxylate synthase 6.3.3.7 Ni-sirohydrochlorin a,c-diamide reductive cyclase 6.3.4.1 Transferred entry: 6.3.5.2 6.3.4.2 CTP synthase (glutamine hydrolyzing) 6.3.4.3 Formate--tetrahydrofolate ligase 6.3.4.4 Adenylosuccinate synthase 6.3.4.5 Argininosuccinate synthase 6.3.4.6 Urea carboxylase 6.3.4.7 Ribose-5-phosphate--ammonia ligase 6.3.4.8 Imidazoleacetate--phosphoribosyldiphosphate ligase 6.3.4.9 Biotin--[methylmalonyl-CoA-carboxytransferase] ligase 6.3.4.10 Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase 6.3.4.11 Biotin--[methylcrotonoyl-CoA-carboxylase] ligase 6.3.4.12 Glutamate--methylamine ligase 6.3.4.13 Phosphoribosylamine--glycine ligase 6.3.4.14 Biotin carboxylase 6.3.4.15 Biotin--[biotin carboxyl-carrier protein] ligase 6.3.4.16 Carbamoyl-phosphate synthase (ammonia) 6.3.4.17 Formate--dihydrofolate ligase 6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase 6.3.4.19 tRNA(Ile)-lysidine synthetase 6.3.4.20 7-cyano-7-deazaguanine synthase 6.3.4.21 Nicotinate phosphoribosyltransferase 6.3.4.22 tRNA(Ile)(2)-agmatinylcytidine synthase 6.3.4.23 Formate--phosphoribosylaminoimidazolecarboxamide ligase 6.3.4.24 Tyramine--L-glutamate ligase 6.3.5.1 NAD(+) synthase (glutamine-hydrolyzing) 6.3.5.2 GMP synthase (glutamine-hydrolyzing) 6.3.5.3 Phosphoribosylformylglycinamidine synthase 6.3.5.4 Asparagine synthase (glutamine-hydrolyzing) 6.3.5.5 Carbamoyl-phosphate synthase (glutamine-hydrolyzing) 6.3.5.6 Asparaginyl-tRNA synthase (glutamine-hydrolyzing) 6.3.5.7 Glutaminyl-tRNA synthase (glutamine-hydrolyzing) 6.3.5.8 Transferred entry: 2.6.1.85 6.3.5.9 Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing) 6.3.5.10 Adenosylcobyric acid synthase (glutamine-hydrolyzing) 6.3.5.11 Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing) 6.3.5.12 Ni-sirohydrochlorin a,c-diamide synthase 6.4.1.1 Pyruvate carboxylase 6.4.1.2 Acetyl-CoA carboxylase 6.4.1.3 Propionyl-CoA carboxylase 6.4.1.4 Methylcrotonoyl-CoA carboxylase 6.4.1.5 Geranoyl-CoA carboxylase 6.4.1.6 Acetone carboxylase 6.4.1.7 2-oxoglutarate carboxylase 6.4.1.8 Acetophenone carboxylase 6.4.1.9 Coenzyme F(430) synthetase 6.5.1.1 DNA ligase (ATP) 6.5.1.2 DNA ligase (NAD(+)) 6.5.1.3 RNA ligase (ATP) 6.5.1.4 RNA 3'-terminal-phosphate cyclase (ATP) 6.5.1.5 RNA 3'-terminal-phosphate cyclase (GTP) 6.5.1.6 DNA ligase (ATP or NAD(+)) 6.5.1.7 DNA ligase (ATP, ADP or GTP) 6.5.1.8 3'-phosphate/5'-hydroxy nucleic acid ligase 6.6.1.1 Magnesium chelatase 6.6.1.2 Cobaltochelatase