ENZYME

ENZYME class: 6

Release of 25-May-22

Ligases

The following ENZYME entries belong to class 6.-.-.-:

6.1.1.1      Tyrosine--tRNA ligase
6.1.1.2      Tryptophan--tRNA ligase
6.1.1.3      Threonine--tRNA ligase
6.1.1.4      Leucine--tRNA ligase
6.1.1.5      Isoleucine--tRNA ligase
6.1.1.6      Lysine--tRNA ligase
6.1.1.7      Alanine--tRNA ligase
6.1.1.8      Deleted entry
6.1.1.9      Valine--tRNA ligase
6.1.1.10     Methionine--tRNA ligase
6.1.1.11     Serine--tRNA ligase
6.1.1.12     Aspartate--tRNA ligase
6.1.1.13     D-alanine--poly(phosphoribitol) ligase
6.1.1.14     Glycine--tRNA ligase
6.1.1.15     Proline--tRNA ligase
6.1.1.16     Cysteine--tRNA ligase
6.1.1.17     Glutamate--tRNA ligase
6.1.1.18     Glutamine--tRNA ligase
6.1.1.19     Arginine--tRNA ligase
6.1.1.20     Phenylalanine--tRNA ligase
6.1.1.21     Histidine--tRNA ligase
6.1.1.22     Asparagine--tRNA ligase
6.1.1.23     Aspartate--tRNA(Asn) ligase
6.1.1.24     Glutamate--tRNA(Gln) ligase
6.1.1.25     Deleted entry
6.1.1.26     Pyrrolysine--tRNA(Pyl) ligase
6.1.1.27     O-phosphoserine--tRNA ligase
6.1.1.28     Deleted entry
6.1.1.n1     Transferred entry: 6.3.1.13
6.1.1.n2     Transferred entry: 6.1.1.27
6.1.2.1      D-alanine--(R)-lactate ligase
6.1.2.2      Nebramycin 5' synthase
6.1.3.1      Olefin beta-lactone synthetase
6.2.1.1      Acetate--CoA ligase
6.2.1.2      Medium-chain acyl-CoA ligase
6.2.1.3      Long-chain-fatty-acid--CoA ligase
6.2.1.4      Succinate--CoA ligase (GDP-forming)
6.2.1.5      Succinate--CoA ligase (ADP-forming)
6.2.1.6      Glutarate--CoA ligase
6.2.1.7      Cholate--CoA ligase
6.2.1.8      Oxalate--CoA ligase
6.2.1.9      Malate--CoA ligase
6.2.1.10     Acid--CoA ligase (GDP-forming)
6.2.1.11     Biotin--CoA ligase
6.2.1.12     4-coumarate--CoA ligase
6.2.1.13     Acetate--CoA ligase (ADP-forming)
6.2.1.14     6-carboxyhexanoate--CoA ligase
6.2.1.15     Arachidonate--CoA ligase
6.2.1.16     Acetoacetate--CoA ligase
6.2.1.17     Propionate--CoA ligase
6.2.1.18     Citrate--CoA ligase
6.2.1.19     Long-chain-fatty-acid--protein ligase
6.2.1.20     Long-chain-fatty-acid--[acyl-carrier-protein] ligase
6.2.1.21     Transferred entry: 6.2.1.30
6.2.1.22     [Citrate (pro-3S)-lyase] ligase
6.2.1.23     Dicarboxylate--CoA ligase
6.2.1.24     Phytanate--CoA ligase
6.2.1.25     Benzoate--CoA ligase
6.2.1.26     o-succinylbenzoate--CoA ligase
6.2.1.27     4-hydroxybenzoate--CoA ligase
6.2.1.28     3-alpha,7-alpha-dihydroxy-5-beta-cholestanate--CoA ligase
6.2.1.29     Transferred entry: 6.2.1.7
6.2.1.30     Phenylacetate--CoA ligase
6.2.1.31     2-furoate--CoA ligase
6.2.1.32     Anthranilate--CoA ligase
6.2.1.33     4-chlorobenzoate--CoA ligase
6.2.1.34     Trans-feruloyl-CoA synthase
6.2.1.35     Acetate--[acyl-carrier protein] ligase
6.2.1.36     3-hydroxypropionyl-CoA synthase
6.2.1.37     3-hydroxybenzoate--CoA ligase
6.2.1.38     (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
6.2.1.39     [Butirosin acyl-carrier protein]--L-glutamate ligase
6.2.1.40     4-hydroxybutyrate--CoA ligase (AMP-forming)
6.2.1.41     3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate-
             -CoA ligase
6.2.1.42     3-oxocholest-4-en-26-oate--CoA ligase
6.2.1.43     2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase
6.2.1.44     3-(methylthio)propionyl--CoA ligase
6.2.1.45     E1 ubiquitin-activating enzyme
6.2.1.46     L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase
6.2.1.47     Medium-chain-fatty-acid--[acyl-carrier-protein] ligase
6.2.1.48     Carnitine--CoA ligase
6.2.1.49     Long-chain fatty acid adenylyltransferase FadD28
6.2.1.50     4-hydroxybenzoate adenylyltransferase FadD22
6.2.1.51     4-hydroxyphenylalkanoate adenylyltransferase FadD29
6.2.1.52     L-firefly luciferin--CoA ligase
6.2.1.53     L-proline--[L-prolyl-carrier protein] ligase
6.2.1.54     D-alanine--[D-alanyl-carrier protein] ligase
6.2.1.55     E1 SAMP-activating enzyme
6.2.1.56     4-hydroxybutyrate--CoA ligase (ADP-forming)
6.2.1.57     Long-chain fatty acid adenylase/transferase FadD23
6.2.1.58     Isophthalate--CoA ligase
6.2.1.59     Long-chain fatty acid adenylase/transferase FadD26
6.2.1.60     Marinolic acid--CoA ligase
6.2.1.61     Salicylate--[aryl-carrier protein] ligase
6.2.1.62     3,4-dihydroxybenzoate--[aryl-carrier protein] ligase
6.2.1.63     L-arginine--[L-arginyl-carrier protein] ligase
6.2.1.64     E1 NEDD8-activating enzyme
6.2.1.65     Salicylate--CoA ligase
6.2.1.66     Glyine--[glycyl-carrier protein] ligase
6.2.1.67     L-alanine--[L-alanyl-carrier protein] ligase
6.2.1.68     L-glutamate--[L-glutamyl-carrier protein] ligase
6.2.1.69     L-cysteine--[L-cysteinyl-carrier protein] ligase
6.2.1.70     L-threonine--[L-threonyl-carrier protein] ligase
6.2.1.71     2,3-dihydroxybenzoate--[aryl-carrier protein] ligase
6.2.1.72     L-serine--[L-seryl-carrier protein] ligase
6.2.1.73     L-tryptophan--[L-tryptophyl-carrier protein] ligase
6.2.1.74     3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase
6.2.1.n1     Transferred entry: 6.2.1.37
6.2.1.n2     Amino acid--[acyl-carrier-protein] ligase
6.2.1.n3     Malonate--CoA ligase
6.2.2.1      Thioglycine synthase
6.2.2.2      Oxazoline synthase
6.2.2.3      Thiazoline synthase
6.3.1.1      Aspartate--ammonia ligase
6.3.1.2      Glutamine synthetase
6.3.1.3      Transferred entry: 6.3.4.13
6.3.1.4      Aspartate--ammonia ligase (ADP-forming)
6.3.1.5      NAD(+) synthase
6.3.1.6      Glutamate--ethylamine ligase
6.3.1.7      4-methyleneglutamate--ammonia ligase
6.3.1.8      Glutathionylspermidine synthase
6.3.1.9      Trypanothione synthase
6.3.1.10     Adenosylcobinamide-phosphate synthase
6.3.1.11     Glutamate--putrescine ligase
6.3.1.12     D-aspartate ligase
6.3.1.13     L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside
             ligase
6.3.1.14     Diphthine--ammonia ligase
6.3.1.15     8-demethylnovobiocic acid synthase
6.3.1.16     Transferred entry: 6.3.3.6
6.3.1.17     Beta-citrylglutamate synthase
6.3.1.18     Gamma-glutamylanilide synthase
6.3.1.19     Prokaryotic ubiquitin-like protein ligase
6.3.1.20     Lipoate--protein ligase
6.3.1.21     Phosphoribosylglycinamide formyltransferase 2
6.3.2.1      Pantoate--beta-alanine ligase (AMP-forming)
6.3.2.2      Glutamate--cysteine ligase
6.3.2.3      Glutathione synthase
6.3.2.4      D-alanine--D-alanine ligase
6.3.2.5      Phosphopantothenate--cysteine ligase (CTP)
6.3.2.6      Phosphoribosylaminoimidazolesuccinocarboxamide synthase
6.3.2.7      UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
6.3.2.8      UDP-N-acetylmuramate--L-alanine ligase
6.3.2.9      UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
6.3.2.10     UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
6.3.2.11     Carnosine synthase
6.3.2.12     Dihydrofolate synthase
6.3.2.13     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
6.3.2.14     Enterobactin synthase
6.3.2.15     Transferred entry: 6.3.2.10
6.3.2.16     D-alanine--alanyl-poly(glycerolphosphate) ligase
6.3.2.17     Tetrahydrofolate synthase
6.3.2.18     Gamma-glutamylhistamine synthase
6.3.2.19     Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45
6.3.2.20     Indoleacetate--lysine synthetase
6.3.2.21     Transferred entry: 2.3.2.27 and 6.2.1.45
6.3.2.22     Transferred entry: 6.3.1.14
6.3.2.23     Homoglutathione synthase
6.3.2.24     Tyrosine--arginine ligase
6.3.2.25     Tubulin--tyrosine ligase
6.3.2.26     N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
6.3.2.27     Transferred entry: 6.3.2.38 and 6.3.2.39
6.3.2.28     Transferred entry: 6.3.2.49
6.3.2.29     Cyanophycin synthase (L-aspartate-adding)
6.3.2.30     Cyanophycin synthase (L-arginine-adding)
6.3.2.31     Coenzyme F420-0:L-glutamate ligase
6.3.2.32     Coenzyme gamma-F420-2:alpha-L-glutamate ligase
6.3.2.33     Tetrahydrosarcinapterin synthase
6.3.2.34     Coenzyme F420-1:gamma-L-glutamate ligase
6.3.2.35     D-alanine--D-serine ligase
6.3.2.36     4-phosphopantoate--beta-alanine ligase
6.3.2.37     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase
6.3.2.38     N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase
6.3.2.39     Aerobactin synthase
6.3.2.40     Cyclopeptine synthase
6.3.2.41     N-acetylaspartylglutamate synthase
6.3.2.42     N-acetylaspartylglutamylglutamate synthase
6.3.2.43     [Amino-group carrier protein]--L-2-aminoadipate ligase
6.3.2.44     Pantoate--beta-alanine ligase (ADP-forming)
6.3.2.45     UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-
             diaminoheptanedioate ligase
6.3.2.46     Fumarate--(S)-2,3-diaminopropanoate ligase
6.3.2.47     Dapdiamide synthase
6.3.2.48     L-arginine-specific L-amino acid ligase
6.3.2.49     L-alanine--L-anticapsin ligase
6.3.2.50     Tenuazonic acid synthetase
6.3.2.51     Phosphopantothenate--cysteine ligase (ATP)
6.3.2.52     Jasmonoyl--L-amino acid ligase
6.3.2.53     UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase
6.3.2.54     L-2,3-diaminopropanoate--citrate ligase
6.3.2.55     2-((L-alanin-3-ylcarbamoyl)methyl)-3-(2-aminoethylcarbamoyl)-2-
             hydroxypropanoate synthase
6.3.2.56     Staphyloferrin B synthase
6.3.2.57     Staphyloferrin A synthase
6.3.2.58     D-ornithine--citrate ligase
6.3.2.59     3-methyl-D-ornithine--L-lysine ligase
6.3.2.60     Glutamate--[amino group carrier protein] ligase
6.3.2.n1     Transferred entry: 6.3.2.37
6.3.2.n2     Transferred entry: 6.3.1.19
6.3.2.n3     ISG15--protein ligase
6.3.2.n4     Transferred entry: 6.3.2.43
6.3.2.n5     Transferred entry: 6.3.2.44
6.3.2.n6     Transferred entry: 6.3.2.41
6.3.3.1      Phosphoribosylformylglycinamidine cyclo-ligase
6.3.3.2      5-formyltetrahydrofolate cyclo-ligase
6.3.3.3      Dethiobiotin synthase
6.3.3.4      (Carboxyethyl)arginine beta-lactam-synthase
6.3.3.5      O-ureido-D-serine cyclo-ligase
6.3.3.6      Carbapenam-3-carboxylate synthase
6.3.3.7      Ni-sirohydrochlorin a,c-diamide reductive cyclase
6.3.4.1      Transferred entry: 6.3.5.2
6.3.4.2      CTP synthase (glutamine hydrolyzing)
6.3.4.3      Formate--tetrahydrofolate ligase
6.3.4.4      Adenylosuccinate synthase
6.3.4.5      Argininosuccinate synthase
6.3.4.6      Urea carboxylase
6.3.4.7      Ribose-5-phosphate--ammonia ligase
6.3.4.8      Imidazoleacetate--phosphoribosyldiphosphate ligase
6.3.4.9      Biotin--[methylmalonyl-CoA-carboxytransferase] ligase
6.3.4.10     Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase
6.3.4.11     Biotin--[methylcrotonoyl-CoA-carboxylase] ligase
6.3.4.12     Glutamate--methylamine ligase
6.3.4.13     Phosphoribosylamine--glycine ligase
6.3.4.14     Biotin carboxylase
6.3.4.15     Biotin--[biotin carboxyl-carrier protein] ligase
6.3.4.16     Carbamoyl-phosphate synthase (ammonia)
6.3.4.17     Formate--dihydrofolate ligase
6.3.4.18     5-(carboxyamino)imidazole ribonucleotide synthase
6.3.4.19     tRNA(Ile)-lysidine synthetase
6.3.4.20     7-cyano-7-deazaguanine synthase
6.3.4.21     Nicotinate phosphoribosyltransferase
6.3.4.22     tRNA(Ile)(2)-agmatinylcytidine synthase
6.3.4.23     Formate--phosphoribosylaminoimidazolecarboxamide ligase
6.3.4.24     Tyramine--L-glutamate ligase
6.3.4.25     2-amino-2'-deoxyadenylo-succinate synthase
6.3.5.1      NAD(+) synthase (glutamine-hydrolyzing)
6.3.5.2      GMP synthase (glutamine-hydrolyzing)
6.3.5.3      Phosphoribosylformylglycinamidine synthase
6.3.5.4      Asparagine synthase (glutamine-hydrolyzing)
6.3.5.5      Carbamoyl-phosphate synthase (glutamine-hydrolyzing)
6.3.5.6      Asparaginyl-tRNA synthase (glutamine-hydrolyzing)
6.3.5.7      Glutaminyl-tRNA synthase (glutamine-hydrolyzing)
6.3.5.8      Transferred entry: 2.6.1.85
6.3.5.9      Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)
6.3.5.10     Adenosylcobyric acid synthase (glutamine-hydrolyzing)
6.3.5.11     Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)
6.3.5.12     Ni-sirohydrochlorin a,c-diamide synthase
6.3.5.13     Lipid II isoglutaminyl synthase (glutamine-hydrolyzing)
6.4.1.1      Pyruvate carboxylase
6.4.1.2      Acetyl-CoA carboxylase
6.4.1.3      Propionyl-CoA carboxylase
6.4.1.4      Methylcrotonoyl-CoA carboxylase
6.4.1.5      Geranoyl-CoA carboxylase
6.4.1.6      Acetone carboxylase
6.4.1.7      2-oxoglutarate carboxylase
6.4.1.8      Acetophenone carboxylase
6.4.1.9      Coenzyme F(430) synthetase
6.5.1.1      DNA ligase (ATP)
6.5.1.2      DNA ligase (NAD(+))
6.5.1.3      RNA ligase (ATP)
6.5.1.4      RNA 3'-terminal-phosphate cyclase (ATP)
6.5.1.5      RNA 3'-terminal-phosphate cyclase (GTP)
6.5.1.6      DNA ligase (ATP or NAD(+))
6.5.1.7      DNA ligase (ATP, ADP or GTP)
6.5.1.8      3'-phosphate/5'-hydroxy nucleic acid ligase
6.5.1.9      Cyclic 2,3-diphosphoglycerate synthase
6.6.1.1      Magnesium chelatase
6.6.1.2      Cobaltochelatase