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ENZYME

ENZYME class: 6.-.-.-

PURL: https://purl.expasy.org/enzyme/EC/6.-.-.-

Release of 18-Jun-25

6.-.-.-: Ligases

All UniProtKB/Swiss-Prot entries corresponding to class 6.-.-.-.

The following ENZYME entries belong to class 6.-.-.-:

6.1.1.1tyrosine--tRNA ligase
6.1.1.2tryptophan--tRNA ligase
6.1.1.3threonine--tRNA ligase
6.1.1.4leucine--tRNA ligase
6.1.1.5isoleucine--tRNA ligase
6.1.1.6lysine--tRNA ligase
6.1.1.7alanine--tRNA ligase
6.1.1.8Deleted entry
6.1.1.9valine--tRNA ligase
6.1.1.10methionine--tRNA ligase
6.1.1.11serine--tRNA ligase
6.1.1.12aspartate--tRNA ligase
6.1.1.13D-alanine--poly(phosphoribitol) ligase
6.1.1.14glycine--tRNA ligase
6.1.1.15proline--tRNA ligase
6.1.1.16cysteine--tRNA ligase
6.1.1.17glutamate--tRNA ligase
6.1.1.18glutamine--tRNA ligase
6.1.1.19arginine--tRNA ligase
6.1.1.20phenylalanine--tRNA ligase
6.1.1.21histidine--tRNA ligase
6.1.1.22asparagine--tRNA ligase
6.1.1.23aspartate--tRNA(Asn) ligase
6.1.1.24glutamate--tRNA(Gln) ligase
6.1.1.25Deleted entry
6.1.1.26pyrrolysine--tRNA(Pyl) ligase
6.1.1.27O-phosphoserine--tRNA ligase
6.1.1.28Deleted entry
6.1.1.n1Transferred entry: 6.3.1.13
6.1.1.n2Transferred entry: 6.1.1.27
6.1.2.1D-alanine--(R)-lactate ligase
6.1.2.2nebramycin 5' synthase
6.1.3.1olefin beta-lactone synthetase
6.2.1.1acetate--CoA ligase
6.2.1.2medium-chain acyl-CoA ligase
6.2.1.3long-chain-fatty-acid--CoA ligase
6.2.1.4succinate--CoA ligase (GDP-forming)
6.2.1.5succinate--CoA ligase (ADP-forming)
6.2.1.6glutarate--CoA ligase
6.2.1.7cholate--CoA ligase
6.2.1.8oxalate--CoA ligase
6.2.1.9malate--CoA ligase
6.2.1.10acid--CoA ligase (GDP-forming)
6.2.1.11biotin--CoA ligase
6.2.1.124-coumarate--CoA ligase
6.2.1.13acetate--CoA ligase (ADP-forming)
6.2.1.146-carboxyhexanoate--CoA ligase
6.2.1.15arachidonate--CoA ligase
6.2.1.16acetoacetate--CoA ligase
6.2.1.17propionate--CoA ligase
6.2.1.18citrate--CoA ligase
6.2.1.19long-chain-fatty-acid--protein ligase
6.2.1.20long-chain-fatty-acid--[acyl-carrier-protein] ligase
6.2.1.21Transferred entry: 6.2.1.30
6.2.1.22[citrate (pro-3S)-lyase] ligase
6.2.1.23dicarboxylate--CoA ligase
6.2.1.24phytanate--CoA ligase
6.2.1.25benzoate--CoA ligase
6.2.1.26o-succinylbenzoate--CoA ligase
6.2.1.274-hydroxybenzoate--CoA ligase
6.2.1.283alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase
6.2.1.29Transferred entry: 6.2.1.7
6.2.1.30phenylacetate--CoA ligase
6.2.1.312-furoate--CoA ligase
6.2.1.32anthranilate--CoA ligase
6.2.1.334-chlorobenzoate--CoA ligase
6.2.1.34trans-feruloyl-CoA synthase
6.2.1.35acetate--[acyl-carrier protein] ligase
6.2.1.363-hydroxypropionyl-CoA synthase
6.2.1.373-hydroxybenzoate--CoA ligase
6.2.1.38(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
6.2.1.39[butirosin acyl-carrier protein]--L-glutamate ligase
6.2.1.404-hydroxybutyrate--CoA ligase (AMP-forming)
6.2.1.413-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-
6.2.1.41-CoA ligase
6.2.1.423-oxocholest-4-en-26-oate--CoA ligase
6.2.1.432-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase
6.2.1.443-(methylthio)propionyl--CoA ligase
6.2.1.45E1 ubiquitin-activating enzyme
6.2.1.46L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase
6.2.1.47medium-chain-fatty-acid--[acyl-carrier-protein] ligase
6.2.1.48carnitine--CoA ligase
6.2.1.49long-chain fatty acid adenylyltransferase FadD28
6.2.1.504-hydroxybenzoate adenylyltransferase FadD22
6.2.1.514-hydroxyphenylalkanoate adenylyltransferase FadD29
6.2.1.52L-firefly luciferin--CoA ligase
6.2.1.53L-proline--[L-prolyl-carrier protein] ligase
6.2.1.54D-alanine--[D-alanyl-carrier protein] ligase
6.2.1.55E1 SAMP-activating enzyme
6.2.1.564-hydroxybutyrate--CoA ligase (ADP-forming)
6.2.1.57long-chain fatty acid adenylase/transferase FadD23
6.2.1.58isophthalate--CoA ligase
6.2.1.59long-chain fatty acid adenylase/transferase FadD26
6.2.1.60marinolic acid--CoA ligase
6.2.1.61salicylate--[aryl-carrier protein] ligase
6.2.1.623,4-dihydroxybenzoate--[aryl-carrier protein] ligase
6.2.1.63L-arginine--[L-arginyl-carrier protein] ligase
6.2.1.64E1 NEDD8-activating enzyme
6.2.1.65salicylate--CoA ligase
6.2.1.66glyine--[glycyl-carrier protein] ligase
6.2.1.67L-alanine--[L-alanyl-carrier protein] ligase
6.2.1.68L-glutamate--[L-glutamyl-carrier protein] ligase
6.2.1.69L-cysteine--[L-cysteinyl-carrier protein] ligase
6.2.1.70L-threonine--[L-threonyl-carrier protein] ligase
6.2.1.712,3-dihydroxybenzoate--[aryl-carrier protein] ligase
6.2.1.72L-serine--[L-seryl-carrier protein] ligase
6.2.1.73L-tryptophan--[L-tryptophyl-carrier protein] ligase
6.2.1.743-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase
6.2.1.75indoleacetate--CoA ligase
6.2.1.76malonate--CoA ligase
6.2.1.n1Transferred entry: 6.2.1.37
6.2.1.n2amino acid--[acyl-carrier-protein] ligase
6.2.1.n3Transferred entry: 6.2.1.76
6.2.2.1thioglycine synthase
6.2.2.2oxazoline synthase
6.2.2.3thiazoline synthase
6.3.1.1aspartate--ammonia ligase
6.3.1.2glutamine synthetase
6.3.1.3Transferred entry: 6.3.4.13
6.3.1.4aspartate--ammonia ligase (ADP-forming)
6.3.1.5NAD(+) synthase
6.3.1.6glutamate--ethylamine ligase
6.3.1.74-methyleneglutamate--ammonia ligase
6.3.1.8glutathionylspermidine synthase
6.3.1.9trypanothione synthase
6.3.1.10adenosylcobinamide-phosphate synthase
6.3.1.11glutamate--putrescine ligase
6.3.1.12D-aspartate ligase
6.3.1.13L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside
6.3.1.13ligase
6.3.1.14diphthine--ammonia ligase
6.3.1.158-demethylnovobiocic acid synthase
6.3.1.16Transferred entry: 6.3.3.6
6.3.1.17beta-citrylglutamate synthase
6.3.1.18gamma-glutamylanilide synthase
6.3.1.19prokaryotic ubiquitin-like protein ligase
6.3.1.20lipoate--protein ligase
6.3.1.21phosphoribosylglycinamide formyltransferase 2
6.3.1.22tRNAmet cytidine acetate ligase
6.3.2.1pantoate--beta-alanine ligase (AMP-forming)
6.3.2.2glutamate--cysteine ligase
6.3.2.3glutathione synthase
6.3.2.4D-alanine--D-alanine ligase
6.3.2.5phosphopantothenate--cysteine ligase (CTP)
6.3.2.6phosphoribosylaminoimidazolesuccinocarboxamide synthase
6.3.2.7UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
6.3.2.8UDP-N-acetylmuramate--L-alanine ligase
6.3.2.9UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
6.3.2.10UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
6.3.2.11carnosine synthase
6.3.2.12dihydrofolate synthase
6.3.2.13UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
6.3.2.14enterobactin synthase
6.3.2.15Transferred entry: 6.3.2.10
6.3.2.16D-alanine--alanyl-poly(glycerolphosphate) ligase
6.3.2.17tetrahydrofolate synthase
6.3.2.18gamma-glutamylhistamine synthase
6.3.2.19Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45
6.3.2.20indoleacetate--lysine synthetase
6.3.2.21Transferred entry: 2.3.2.27 and 6.2.1.45
6.3.2.22Transferred entry: 6.3.1.14
6.3.2.23homoglutathione synthase
6.3.2.24tyrosine--arginine ligase
6.3.2.25tubulin--tyrosine ligase
6.3.2.26N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
6.3.2.27Transferred entry: 6.3.2.38 and 6.3.2.39
6.3.2.28Transferred entry: 6.3.2.49
6.3.2.29cyanophycin synthase (L-aspartate-adding)
6.3.2.30cyanophycin synthase (L-arginine-adding)
6.3.2.31coenzyme F420-0:L-glutamate ligase
6.3.2.32coenzyme gamma-F420-2:alpha-L-glutamate ligase
6.3.2.33tetrahydrosarcinapterin synthase
6.3.2.34coenzyme F420-1:gamma-L-glutamate ligase
6.3.2.35D-alanine--D-serine ligase
6.3.2.364-phosphopantoate--beta-alanine ligase
6.3.2.37UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase
6.3.2.38N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase
6.3.2.39aerobactin synthase
6.3.2.40cyclopeptine synthase
6.3.2.41N-acetylaspartylglutamate synthase
6.3.2.42N-acetylaspartylglutamylglutamate synthase
6.3.2.43[amino-group carrier protein]--L-2-aminoadipate ligase
6.3.2.44pantoate--beta-alanine ligase (ADP-forming)
6.3.2.45UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-
6.3.2.45diaminoheptanedioate ligase
6.3.2.46fumarate--(S)-2,3-diaminopropanoate ligase
6.3.2.47dapdiamide synthase
6.3.2.48L-arginine-specific L-amino acid ligase
6.3.2.49L-alanine--L-anticapsin ligase
6.3.2.50tenuazonic acid synthetase
6.3.2.51phosphopantothenate--cysteine ligase (ATP)
6.3.2.52jasmonoyl--L-amino acid ligase
6.3.2.53UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase
6.3.2.54L-2,3-diaminopropanoate--citrate ligase
6.3.2.552-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-
6.3.2.55hydroxypropanoate synthase
6.3.2.56staphyloferrin B synthase
6.3.2.57staphyloferrin A synthase
6.3.2.58D-ornithine--citrate ligase
6.3.2.593-methyl-D-ornithine--L-lysine ligase
6.3.2.60glutamate--[amino group carrier protein] ligase
6.3.2.61tubulin-glutamate ligase
6.3.2.62beta-tubulin-glutamate ligase
6.3.2.63putrebactin synthase
6.3.2.64bisucaberin synthase
6.3.2.65UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactose--2-oxoglutarate
6.3.2.65ligase
6.3.2.n1Transferred entry: 6.3.2.37
6.3.2.n2Transferred entry: 6.3.1.19
6.3.2.n3ISG15--protein ligase
6.3.2.n4Transferred entry: 6.3.2.43
6.3.2.n5Transferred entry: 6.3.2.44
6.3.2.n6Transferred entry: 6.3.2.41
6.3.3.1phosphoribosylformylglycinamidine cyclo-ligase
6.3.3.25-formyltetrahydrofolate cyclo-ligase
6.3.3.3dethiobiotin synthase
6.3.3.4(carboxyethyl)arginine beta-lactam-synthase
6.3.3.5O-ureido-D-serine cyclo-ligase
6.3.3.6carbapenam-3-carboxylate synthase
6.3.3.7Ni-sirohydrochlorin a,c-diamide reductive cyclase
6.3.4.1Transferred entry: 6.3.5.2
6.3.4.2CTP synthase (glutamine hydrolyzing)
6.3.4.3formate--tetrahydrofolate ligase
6.3.4.4adenylosuccinate synthase
6.3.4.5argininosuccinate synthase
6.3.4.6urea carboxylase
6.3.4.7ribose-5-phosphate--ammonia ligase
6.3.4.8imidazoleacetate--phosphoribosyldiphosphate ligase
6.3.4.9biotin--[methylmalonyl-CoA-carboxytransferase] ligase
6.3.4.10biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase
6.3.4.11biotin--[methylcrotonoyl-CoA-carboxylase] ligase
6.3.4.12glutamate--methylamine ligase
6.3.4.13phosphoribosylamine--glycine ligase
6.3.4.14biotin carboxylase
6.3.4.15biotin--[biotin carboxyl-carrier protein] ligase
6.3.4.16carbamoyl-phosphate synthase (ammonia)
6.3.4.17formate--dihydrofolate ligase
6.3.4.185-(carboxyamino)imidazole ribonucleotide synthase
6.3.4.19tRNA(Ile)-lysidine synthetase
6.3.4.207-cyano-7-deazaguanine synthase
6.3.4.21nicotinate phosphoribosyltransferase
6.3.4.22tRNA(Ile)(2)-agmatinylcytidine synthase
6.3.4.23formate--phosphoribosylaminoimidazolecarboxamide ligase
6.3.4.24tyramine--L-glutamate ligase
6.3.4.252-amino-2'-deoxyadenylo-succinate synthase
6.3.5.1NAD(+) synthase (glutamine-hydrolyzing)
6.3.5.2GMP synthase (glutamine-hydrolyzing)
6.3.5.3phosphoribosylformylglycinamidine synthase
6.3.5.4asparagine synthase (glutamine-hydrolyzing)
6.3.5.5carbamoyl-phosphate synthase (glutamine-hydrolyzing)
6.3.5.6asparaginyl-tRNA synthase (glutamine-hydrolyzing)
6.3.5.7glutaminyl-tRNA synthase (glutamine-hydrolyzing)
6.3.5.8Transferred entry: 2.6.1.85
6.3.5.9hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)
6.3.5.10adenosylcobyric acid synthase (glutamine-hydrolyzing)
6.3.5.11cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)
6.3.5.12Ni-sirohydrochlorin a,c-diamide synthase
6.3.5.13lipid II isoglutaminyl synthase (glutamine-hydrolyzing)
6.4.1.1pyruvate carboxylase
6.4.1.2acetyl-CoA carboxylase
6.4.1.3propionyl-CoA carboxylase
6.4.1.4methylcrotonoyl-CoA carboxylase
6.4.1.5geranoyl-CoA carboxylase
6.4.1.6acetone carboxylase
6.4.1.72-oxoglutarate carboxylase
6.4.1.8acetophenone carboxylase
6.4.1.9coenzyme F430 synthetase
6.5.1.1DNA ligase (ATP)
6.5.1.2DNA ligase (NAD(+))
6.5.1.3RNA ligase (ATP)
6.5.1.4RNA 3'-terminal-phosphate cyclase (ATP)
6.5.1.5RNA 3'-terminal-phosphate cyclase (GTP)
6.5.1.6DNA ligase (ATP or NAD(+))
6.5.1.7DNA ligase (ATP, ADP or GTP)
6.5.1.83'-phosphate/5'-hydroxy nucleic acid ligase
6.5.1.9cyclic 2,3-diphosphoglycerate synthase
6.6.1.1magnesium chelatase
6.6.1.2cobaltochelatase
6.7.1.13-amino-2-hydroxy-4-methoxybenzoate diazotase
6.7.1.23-aminoavenalumate diazotase