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ENZYME class: 6

Release of 12-Oct-22


Ligases

All UniProtKB/Swiss-Prot entries corresponding to class 6.-.-.-.

The following ENZYME entries belong to class 6.-.-.-:

6.1.1.1      tyrosine--tRNA ligase
6.1.1.2      tryptophan--tRNA ligase
6.1.1.3      threonine--tRNA ligase
6.1.1.4      leucine--tRNA ligase
6.1.1.5      isoleucine--tRNA ligase
6.1.1.6      lysine--tRNA ligase
6.1.1.7      alanine--tRNA ligase
6.1.1.8      Deleted entry
6.1.1.9      valine--tRNA ligase
6.1.1.10     methionine--tRNA ligase
6.1.1.11     serine--tRNA ligase
6.1.1.12     aspartate--tRNA ligase
6.1.1.13     D-alanine--poly(phosphoribitol) ligase
6.1.1.14     glycine--tRNA ligase
6.1.1.15     proline--tRNA ligase
6.1.1.16     cysteine--tRNA ligase
6.1.1.17     glutamate--tRNA ligase
6.1.1.18     glutamine--tRNA ligase
6.1.1.19     arginine--tRNA ligase
6.1.1.20     phenylalanine--tRNA ligase
6.1.1.21     histidine--tRNA ligase
6.1.1.22     asparagine--tRNA ligase
6.1.1.23     aspartate--tRNA(Asn) ligase
6.1.1.24     glutamate--tRNA(Gln) ligase
6.1.1.25     Deleted entry
6.1.1.26     pyrrolysine--tRNA(Pyl) ligase
6.1.1.27     O-phosphoserine--tRNA ligase
6.1.1.28     Deleted entry
6.1.1.n1     Transferred entry: 6.3.1.13
6.1.1.n2     Transferred entry: 6.1.1.27
6.1.2.1      D-alanine--(R)-lactate ligase
6.1.2.2      nebramycin 5' synthase
6.1.3.1      olefin beta-lactone synthetase
6.2.1.1      acetate--CoA ligase
6.2.1.2      medium-chain acyl-CoA ligase
6.2.1.3      long-chain-fatty-acid--CoA ligase
6.2.1.4      succinate--CoA ligase (GDP-forming)
6.2.1.5      succinate--CoA ligase (ADP-forming)
6.2.1.6      glutarate--CoA ligase
6.2.1.7      cholate--CoA ligase
6.2.1.8      oxalate--CoA ligase
6.2.1.9      malate--CoA ligase
6.2.1.10     acid--CoA ligase (GDP-forming)
6.2.1.11     biotin--CoA ligase
6.2.1.12     4-coumarate--CoA ligase
6.2.1.13     acetate--CoA ligase (ADP-forming)
6.2.1.14     6-carboxyhexanoate--CoA ligase
6.2.1.15     arachidonate--CoA ligase
6.2.1.16     acetoacetate--CoA ligase
6.2.1.17     propionate--CoA ligase
6.2.1.18     citrate--CoA ligase
6.2.1.19     long-chain-fatty-acid--protein ligase
6.2.1.20     long-chain-fatty-acid--[acyl-carrier-protein] ligase
6.2.1.21     Transferred entry: 6.2.1.30
6.2.1.22     [citrate (pro-3S)-lyase] ligase
6.2.1.23     dicarboxylate--CoA ligase
6.2.1.24     phytanate--CoA ligase
6.2.1.25     benzoate--CoA ligase
6.2.1.26     o-succinylbenzoate--CoA ligase
6.2.1.27     4-hydroxybenzoate--CoA ligase
6.2.1.28     3alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase
6.2.1.29     Transferred entry: 6.2.1.7
6.2.1.30     phenylacetate--CoA ligase
6.2.1.31     2-furoate--CoA ligase
6.2.1.32     anthranilate--CoA ligase
6.2.1.33     4-chlorobenzoate--CoA ligase
6.2.1.34     trans-feruloyl-CoA synthase
6.2.1.35     acetate--[acyl-carrier protein] ligase
6.2.1.36     3-hydroxypropionyl-CoA synthase
6.2.1.37     3-hydroxybenzoate--CoA ligase
6.2.1.38     (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
6.2.1.39     [butirosin acyl-carrier protein]--L-glutamate ligase
6.2.1.40     4-hydroxybutyrate--CoA ligase (AMP-forming)
6.2.1.41     3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-
             -CoA ligase
6.2.1.42     3-oxocholest-4-en-26-oate--CoA ligase
6.2.1.43     2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase
6.2.1.44     3-(methylthio)propionyl--CoA ligase
6.2.1.45     E1 ubiquitin-activating enzyme
6.2.1.46     L-allo-isoleucine--holo-[CmaA peptidyl-carrier protein] ligase
6.2.1.47     medium-chain-fatty-acid--[acyl-carrier-protein] ligase
6.2.1.48     carnitine--CoA ligase
6.2.1.49     long-chain fatty acid adenylyltransferase FadD28
6.2.1.50     4-hydroxybenzoate adenylyltransferase FadD22
6.2.1.51     4-hydroxyphenylalkanoate adenylyltransferase FadD29
6.2.1.52     L-firefly luciferin--CoA ligase
6.2.1.53     L-proline--[L-prolyl-carrier protein] ligase
6.2.1.54     D-alanine--[D-alanyl-carrier protein] ligase
6.2.1.55     E1 SAMP-activating enzyme
6.2.1.56     4-hydroxybutyrate--CoA ligase (ADP-forming)
6.2.1.57     long-chain fatty acid adenylase/transferase FadD23
6.2.1.58     isophthalate--CoA ligase
6.2.1.59     long-chain fatty acid adenylase/transferase FadD26
6.2.1.60     marinolic acid--CoA ligase
6.2.1.61     salicylate--[aryl-carrier protein] ligase
6.2.1.62     3,4-dihydroxybenzoate--[aryl-carrier protein] ligase
6.2.1.63     L-arginine--[L-arginyl-carrier protein] ligase
6.2.1.64     E1 NEDD8-activating enzyme
6.2.1.65     salicylate--CoA ligase
6.2.1.66     glyine--[glycyl-carrier protein] ligase
6.2.1.67     L-alanine--[L-alanyl-carrier protein] ligase
6.2.1.68     L-glutamate--[L-glutamyl-carrier protein] ligase
6.2.1.69     L-cysteine--[L-cysteinyl-carrier protein] ligase
6.2.1.70     L-threonine--[L-threonyl-carrier protein] ligase
6.2.1.71     2,3-dihydroxybenzoate--[aryl-carrier protein] ligase
6.2.1.72     L-serine--[L-seryl-carrier protein] ligase
6.2.1.73     L-tryptophan--[L-tryptophyl-carrier protein] ligase
6.2.1.74     3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase
6.2.1.n1     Transferred entry: 6.2.1.37
6.2.1.n2     amino acid--[acyl-carrier-protein] ligase
6.2.1.n3     malonate--CoA ligase
6.2.2.1      thioglycine synthase
6.2.2.2      oxazoline synthase
6.2.2.3      thiazoline synthase
6.3.1.1      aspartate--ammonia ligase
6.3.1.2      glutamine synthetase
6.3.1.3      Transferred entry: 6.3.4.13
6.3.1.4      aspartate--ammonia ligase (ADP-forming)
6.3.1.5      NAD(+) synthase
6.3.1.6      glutamate--ethylamine ligase
6.3.1.7      4-methyleneglutamate--ammonia ligase
6.3.1.8      glutathionylspermidine synthase
6.3.1.9      trypanothione synthase
6.3.1.10     adenosylcobinamide-phosphate synthase
6.3.1.11     glutamate--putrescine ligase
6.3.1.12     D-aspartate ligase
6.3.1.13     L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside
             ligase
6.3.1.14     diphthine--ammonia ligase
6.3.1.15     8-demethylnovobiocic acid synthase
6.3.1.16     Transferred entry: 6.3.3.6
6.3.1.17     beta-citrylglutamate synthase
6.3.1.18     gamma-glutamylanilide synthase
6.3.1.19     prokaryotic ubiquitin-like protein ligase
6.3.1.20     lipoate--protein ligase
6.3.1.21     phosphoribosylglycinamide formyltransferase 2
6.3.2.1      pantoate--beta-alanine ligase (AMP-forming)
6.3.2.2      glutamate--cysteine ligase
6.3.2.3      glutathione synthase
6.3.2.4      D-alanine--D-alanine ligase
6.3.2.5      phosphopantothenate--cysteine ligase (CTP)
6.3.2.6      phosphoribosylaminoimidazolesuccinocarboxamide synthase
6.3.2.7      UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
6.3.2.8      UDP-N-acetylmuramate--L-alanine ligase
6.3.2.9      UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
6.3.2.10     UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
6.3.2.11     carnosine synthase
6.3.2.12     dihydrofolate synthase
6.3.2.13     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
6.3.2.14     enterobactin synthase
6.3.2.15     Transferred entry: 6.3.2.10
6.3.2.16     D-alanine--alanyl-poly(glycerolphosphate) ligase
6.3.2.17     tetrahydrofolate synthase
6.3.2.18     gamma-glutamylhistamine synthase
6.3.2.19     Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45
6.3.2.20     indoleacetate--lysine synthetase
6.3.2.21     Transferred entry: 2.3.2.27 and 6.2.1.45
6.3.2.22     Transferred entry: 6.3.1.14
6.3.2.23     homoglutathione synthase
6.3.2.24     tyrosine--arginine ligase
6.3.2.25     tubulin--tyrosine ligase
6.3.2.26     N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
6.3.2.27     Transferred entry: 6.3.2.38 and 6.3.2.39
6.3.2.28     Transferred entry: 6.3.2.49
6.3.2.29     cyanophycin synthase (L-aspartate-adding)
6.3.2.30     cyanophycin synthase (L-arginine-adding)
6.3.2.31     coenzyme F420-0:L-glutamate ligase
6.3.2.32     coenzyme gamma-F420-2:alpha-L-glutamate ligase
6.3.2.33     tetrahydrosarcinapterin synthase
6.3.2.34     coenzyme F420-1:gamma-L-glutamate ligase
6.3.2.35     D-alanine--D-serine ligase
6.3.2.36     4-phosphopantoate--beta-alanine ligase
6.3.2.37     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase
6.3.2.38     N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase
6.3.2.39     aerobactin synthase
6.3.2.40     cyclopeptine synthase
6.3.2.41     N-acetylaspartylglutamate synthase
6.3.2.42     N-acetylaspartylglutamylglutamate synthase
6.3.2.43     [amino-group carrier protein]--L-2-aminoadipate ligase
6.3.2.44     pantoate--beta-alanine ligase (ADP-forming)
6.3.2.45     UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-
             diaminoheptanedioate ligase
6.3.2.46     fumarate--(S)-2,3-diaminopropanoate ligase
6.3.2.47     dapdiamide synthase
6.3.2.48     L-arginine-specific L-amino acid ligase
6.3.2.49     L-alanine--L-anticapsin ligase
6.3.2.50     tenuazonic acid synthetase
6.3.2.51     phosphopantothenate--cysteine ligase (ATP)
6.3.2.52     jasmonoyl--L-amino acid ligase
6.3.2.53     UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase
6.3.2.54     L-2,3-diaminopropanoate--citrate ligase
6.3.2.55     2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-
             hydroxypropanoate synthase
6.3.2.56     staphyloferrin B synthase
6.3.2.57     staphyloferrin A synthase
6.3.2.58     D-ornithine--citrate ligase
6.3.2.59     3-methyl-D-ornithine--L-lysine ligase
6.3.2.60     glutamate--[amino group carrier protein] ligase
6.3.2.n1     Transferred entry: 6.3.2.37
6.3.2.n2     Transferred entry: 6.3.1.19
6.3.2.n3     ISG15--protein ligase
6.3.2.n4     Transferred entry: 6.3.2.43
6.3.2.n5     Transferred entry: 6.3.2.44
6.3.2.n6     Transferred entry: 6.3.2.41
6.3.3.1      phosphoribosylformylglycinamidine cyclo-ligase
6.3.3.2      5-formyltetrahydrofolate cyclo-ligase
6.3.3.3      dethiobiotin synthase
6.3.3.4      (carboxyethyl)arginine beta-lactam-synthase
6.3.3.5      O-ureido-D-serine cyclo-ligase
6.3.3.6      carbapenam-3-carboxylate synthase
6.3.3.7      Ni-sirohydrochlorin a,c-diamide reductive cyclase
6.3.4.1      Transferred entry: 6.3.5.2
6.3.4.2      CTP synthase (glutamine hydrolyzing)
6.3.4.3      formate--tetrahydrofolate ligase
6.3.4.4      adenylosuccinate synthase
6.3.4.5      argininosuccinate synthase
6.3.4.6      urea carboxylase
6.3.4.7      ribose-5-phosphate--ammonia ligase
6.3.4.8      imidazoleacetate--phosphoribosyldiphosphate ligase
6.3.4.9      biotin--[methylmalonyl-CoA-carboxytransferase] ligase
6.3.4.10     biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase
6.3.4.11     biotin--[methylcrotonoyl-CoA-carboxylase] ligase
6.3.4.12     glutamate--methylamine ligase
6.3.4.13     phosphoribosylamine--glycine ligase
6.3.4.14     biotin carboxylase
6.3.4.15     biotin--[biotin carboxyl-carrier protein] ligase
6.3.4.16     carbamoyl-phosphate synthase (ammonia)
6.3.4.17     formate--dihydrofolate ligase
6.3.4.18     5-(carboxyamino)imidazole ribonucleotide synthase
6.3.4.19     tRNA(Ile)-lysidine synthetase
6.3.4.20     7-cyano-7-deazaguanine synthase
6.3.4.21     nicotinate phosphoribosyltransferase
6.3.4.22     tRNA(Ile)(2)-agmatinylcytidine synthase
6.3.4.23     formate--phosphoribosylaminoimidazolecarboxamide ligase
6.3.4.24     tyramine--L-glutamate ligase
6.3.4.25     2-amino-2'-deoxyadenylo-succinate synthase
6.3.5.1      NAD(+) synthase (glutamine-hydrolyzing)
6.3.5.2      GMP synthase (glutamine-hydrolyzing)
6.3.5.3      phosphoribosylformylglycinamidine synthase
6.3.5.4      asparagine synthase (glutamine-hydrolyzing)
6.3.5.5      carbamoyl-phosphate synthase (glutamine-hydrolyzing)
6.3.5.6      asparaginyl-tRNA synthase (glutamine-hydrolyzing)
6.3.5.7      glutaminyl-tRNA synthase (glutamine-hydrolyzing)
6.3.5.8      Transferred entry: 2.6.1.85
6.3.5.9      hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)
6.3.5.10     adenosylcobyric acid synthase (glutamine-hydrolyzing)
6.3.5.11     cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)
6.3.5.12     Ni-sirohydrochlorin a,c-diamide synthase
6.3.5.13     lipid II isoglutaminyl synthase (glutamine-hydrolyzing)
6.4.1.1      pyruvate carboxylase
6.4.1.2      acetyl-CoA carboxylase
6.4.1.3      propionyl-CoA carboxylase
6.4.1.4      methylcrotonoyl-CoA carboxylase
6.4.1.5      geranoyl-CoA carboxylase
6.4.1.6      acetone carboxylase
6.4.1.7      2-oxoglutarate carboxylase
6.4.1.8      acetophenone carboxylase
6.4.1.9      coenzyme F430 synthetase
6.5.1.1      DNA ligase (ATP)
6.5.1.2      DNA ligase (NAD(+))
6.5.1.3      RNA ligase (ATP)
6.5.1.4      RNA 3'-terminal-phosphate cyclase (ATP)
6.5.1.5      RNA 3'-terminal-phosphate cyclase (GTP)
6.5.1.6      DNA ligase (ATP or NAD(+))
6.5.1.7      DNA ligase (ATP, ADP or GTP)
6.5.1.8      3'-phosphate/5'-hydroxy nucleic acid ligase
6.5.1.9      cyclic 2,3-diphosphoglycerate synthase
6.6.1.1      magnesium chelatase
6.6.1.2      cobaltochelatase