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ENZYME entry: EC 6.2.1.37

Accepted Name
3-hydroxybenzoate--CoA ligase.
Alternative Name(s)
3-hydroxybenzoate--coenzyme A ligase (AMP-forming).
3-hydroxybenzoyl-CoA synthetase.
Reaction catalysed
ATP + 3-hydroxybenzoate + CoA <=> AMP + diphosphate + 3-hydroxybenzoyl-CoA
Comment(s)
  • The enzyme works equally well with 4-hydroxybenzoate but shows low activity toward benzoate, 4-aminobenzoate, 3-aminobenzoate, 3-fluorobenzoate, 4-fluorobenzoate, 3-chlorobenzoate, and 4-chlorobenzoate.
  • There is no activity with 3,4-dihydroxybenzoate, 2,3- dihydroxybenzoate, and 2-hydroxybenzoate as substrates.
  • Formerly EC 6.2.1.n1.
Cross-references
BRENDA6.2.1.37
EC2PDB6.2.1.37
ExplorEnz6.2.1.37
PRIAM enzyme-specific profiles6.2.1.37
KEGG Ligand Database for Enzyme Nomenclature6.2.1.37
IUBMB Enzyme Nomenclature6.2.1.37
IntEnz6.2.1.37
MEDLINEFind literature relating to 6.2.1.37
MetaCyc6.2.1.37
Rhea expert-curated reactions6.2.1.37
UniProtKB/Swiss-Prot
Q9AJS8, 3HBCL_THAAR

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