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ENZYME entry: EC 6.2.1.41

Accepted Name
3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate- -CoA ligase.
Alternative Name(s)
HIP--CoA ligase.
Reaction catalysed
ATP + 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate + CoA <=> AMP + diphosphate + 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoyl-CoA
Comment(s)
  • The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyzes a step in the degradation of cholesterol and cholate.
  • The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed.
Cross-references
BRENDA6.2.1.41
EC2PDB6.2.1.41
ExplorEnz6.2.1.41
PRIAM enzyme-specific profiles6.2.1.41
KEGG Ligand Database for Enzyme Nomenclature6.2.1.41
IUBMB Enzyme Nomenclature6.2.1.41
IntEnz6.2.1.41
MEDLINEFind literature relating to 6.2.1.41
MetaCyc6.2.1.41
Rhea expert-curated reactions6.2.1.41
UniProtKB/Swiss-Prot
P96843, FAD3_MYCTU;  Q0S7V5, FAD3_RHOJR;  Q7WSH3, FADD3_COMTE;  

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