ENZYME entry: EC 6.2.1.41

PURL: https://purl.expasy.org/enzyme/EC/6.2.1.41

Accepted Name

3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate- -CoA ligase

Alternative Name(s)

HIP--CoA ligase

Reaction catalysed

3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate

Comment(s)

The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyzes a step in the degradation of cholesterol and cholate.
The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed.

Cross-references

BRENDA

6.2.1.41

EC2PDB

6.2.1.41

ExplorEnz

6.2.1.41

KEGG Ligand Database for Enzyme Nomenclature

6.2.1.41

IUBMB Enzyme Nomenclature

6.2.1.41

MEDLINE

Find literature relating to 6.2.1.41

MetaCyc

6.2.1.41

Rhea expert-curated reactions

6.2.1.41

UniProtKB/Swiss-Prot

P96843, FAD3_MYCTU

Q0S7V5, FAD3_RHOJR

Q7WSH3, FADD3_COMTE

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-