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ENZYME entry: EC 6.2.1.41
Accepted Name |
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-
-CoA ligase.
|
Alternative Name(s) |
HIP--CoA ligase. |
Reaction catalysed |
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate |
Comment(s) |
- The enzyme, characterized from actinobacterium Mycobacterium
tuberculosis, catalyzes a step in the degradation of cholesterol and
cholate.
- The enzyme is very specific for its substrate, and requires that the
side chain at C17 is completely removed.
|
Cross-references |
BRENDA | 6.2.1.41 |
EC2PDB | 6.2.1.41 |
ExplorEnz | 6.2.1.41 |
PRIAM enzyme-specific profiles | 6.2.1.41 |
KEGG Ligand Database for Enzyme Nomenclature | 6.2.1.41 |
IUBMB Enzyme Nomenclature | 6.2.1.41 |
IntEnz | 6.2.1.41 |
MEDLINE | Find literature relating to 6.2.1.41 |
MetaCyc | 6.2.1.41 |
Rhea expert-curated reactions | 6.2.1.41 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-