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ENZYME

ENZYME entry: EC 6.2.1.41

Accepted Name
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate- -CoA ligase
Alternative Name(s)
HIP--CoA ligase
Reaction catalysed
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate
Comment(s)
  • The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyzes a step in the degradation of cholesterol and cholate.
  • The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed.
Cross-references
BRENDA6.2.1.41
EC2PDB6.2.1.41
ExplorEnz6.2.1.41
PRIAM enzyme-specific profiles6.2.1.41
KEGG Ligand Database for Enzyme Nomenclature6.2.1.41
IUBMB Enzyme Nomenclature6.2.1.41
IntEnz6.2.1.41
MEDLINEFind literature relating to 6.2.1.41
MetaCyc6.2.1.41
Rhea expert-curated reactions6.2.1.41
UniProtKB/Swiss-Prot
P96843, FAD3_MYCTUQ0S7V5, FAD3_RHOJRQ7WSH3, FADD3_COMTE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
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