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ENZYME

ENZYME entry: EC 6.2.1.42

PURL: https://purl.expasy.org/enzyme/EC/6.2.1.42
Accepted Name
3-oxocholest-4-en-26-oate--CoA ligase
Reaction catalysed
(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate
Comment(s)
  • The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyzes a step in the degradation of cholesterol.
  • It is responsible for the activation of the C8 side chain.
  • 3beta-hydroxycholest-5-en-26-oate can also be used as substrate.
Cross-references
BRENDA6.2.1.42
EC2PDB6.2.1.42
ExplorEnz6.2.1.42
KEGG Ligand Database for Enzyme Nomenclature6.2.1.42
IUBMB Enzyme Nomenclature6.2.1.42
MEDLINEFind literature relating to 6.2.1.42
MetaCyc6.2.1.42
Rhea expert-curated reactions6.2.1.42
UniProtKB/Swiss-Prot
Q7TWB7, FAC19_MYCBOB2HI05, FAC19_MYCMMA0R4Q2, FAC19_MYCS2
P9WQ50, FAC19_MYCTOP9WQ51, FAC19_MYCTUE3UUE6, FAC19_RHORH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-