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ENZYME entry: EC 6.2.1.54

Accepted Name
D-alanine--[D-alanyl-carrier protein] ligase.
Reaction catalysed
ATP + D-alanine + holo-[D-alaninyl-carrier protein] <=> AMP + diphosphate + D-alanyl-[D-alanyl-carrier protein]
Comment(s)
  • The enzyme is involved in the modification of wall teichoic acids, as well as type I and IV lipoteichoic acids, with D-alanine residues.
  • It activates D-alanine using ATP to form a high-energy (D-alanyl)adenylate intermediate and subsequently transfers the alanyl moiety to the phosphopantheinyl prosthetic group of a D-alanyl-carrier protein (DltC).
Cross-references
BRENDA6.2.1.54
EC2PDB6.2.1.54
ExplorEnz6.2.1.54
PRIAM enzyme-specific profiles6.2.1.54
KEGG Ligand Database for Enzyme Nomenclature6.2.1.54
IUBMB Enzyme Nomenclature6.2.1.54
IntEnz6.2.1.54
MEDLINEFind literature relating to 6.2.1.54
MetaCyc6.2.1.54
UniProtKB/Swiss-Prot
C3P4I7, DLTA_BACAA;  C3LAH8, DLTA_BACAC;  A0RBJ0, DLTA_BACAH;  
Q81T97, DLTA_BACAN;  B7JFV5, DLTA_BACC0;  Q73BD2, DLTA_BACC1;  
B7IN64, DLTA_BACC2;  C1EM80, DLTA_BACC3;  B7HHC6, DLTA_BACC4;  
B7HK95, DLTA_BACC7;  A7GMR0, DLTA_BACCN;  B9IUW2, DLTA_BACCQ;  
Q81G39, DLTA_BACCR;  Q63E02, DLTA_BACCZ;  Q6HLH7, DLTA_BACHK;  
Q65DH1, DLTA_BACLD;  A9VKV6, DLTA_BACMK;  P39581, DLTA_BACSU;  
A7ZA74, DLTA_BACVZ;  B3WC77, DLTA_LACCB;  Q9CG49, DLTA_LACLA;  
Q03AZ2, DLTA_LACP3;  Q88VM6, DLTA_LACPL;  P35854, DLTA_LACRH;  
Q92D47, DLTA_LISIN;  C1L1P5, DLTA_LISMC;  Q721J2, DLTA_LISMF;  
B8DEG2, DLTA_LISMH;  Q8Y8D4, DLTA_LISMO;  A0AH92, DLTA_LISW6;  
A7X0D6, DLTA_STAA1;  A6U039, DLTA_STAA2;  Q2FIE3, DLTA_STAA3;  
Q2FZW6, DLTA_STAA8;  A5IRB0, DLTA_STAA9;  Q2YWQ8, DLTA_STAAB;  
Q5HHF2, DLTA_STAAC;  A6QFE3, DLTA_STAAE;  P68876, DLTA_STAAM;  
P99107, DLTA_STAAN;  Q6GIF6, DLTA_STAAR;  Q6GAZ4, DLTA_STAAS;  
A8Z1J1, DLTA_STAAT;  P0C397, DLTA_STAAU;  P68878, DLTA_STAAW;  
Q5HQN0, DLTA_STAEQ;  Q8CT93, DLTA_STAES;  Q4L4U5, DLTA_STAHJ;  
Q9X2N4, DLTA_STAXY;  Q3JZ94, DLTA_STRA1;  Q8VM67, DLTA_STRA3;  
P59591, DLTA_STRA5;  C0MBD6, DLTA_STRE4;  Q53526, DLTA_STRMU;  
Q99ZA6, DLTA_STRP1;  Q04HZ7, DLTA_STRP2;  P0DA64, DLTA_STRP3;  
Q5XBN5, DLTA_STRP6;  C1CB20, DLTA_STRP7;  Q8P0J9, DLTA_STRP8;  
Q1JLB7, DLTA_STRPC;  Q1JGF0, DLTA_STRPD;  Q1J667, DLTA_STRPF;  
A2RE45, DLTA_STRPG;  B8ZQ14, DLTA_STRPJ;  Q48SZ3, DLTA_STRPM;  
P0A398, DLTA_STRPN;  P0DA65, DLTA_STRPQ;  B5XLX5, DLTA_STRPZ;  
P0A399, DLTA_STRR6;  C1CNE9, DLTA_STRZP;  C1CU95, DLTA_STRZT;  

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