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ENZYME entry: EC 6.2.1.61

Accepted Name
Salicylate--[aryl-carrier protein] ligase.
Reaction catalysed
ATP + salicylate + holo-[non-ribosomal peptide synthase] <=> AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]
Comment(s)
  • The enzyme catalyzes the activation of salicylate to (salicyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl- carrier protein, which is often a domain of a larger non-ribosimal peptide synthase.
  • The PmsE enzyme is involved in pseudomonine biosynthesis and transfers the activated salicylate first to itself, and then to a PmsG protein.
  • The PchD enzyme is involved in pyochelin biosynthesis and transfers the activated salicylate directly to the PchE protein.
Cross-references
BRENDA6.2.1.61
EC2PDB6.2.1.61
ExplorEnz6.2.1.61
PRIAM enzyme-specific profiles6.2.1.61
KEGG Ligand Database for Enzyme Nomenclature6.2.1.61
IUBMB Enzyme Nomenclature6.2.1.61
IntEnz6.2.1.61
MEDLINEFind literature relating to 6.2.1.61
MetaCyc6.2.1.61
Rhea expert-curated reactions6.2.1.61

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-