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ENZYME entry: EC 6.2.1.62

Accepted Name
3,4-dihydroxybenzoate--[aryl-carrier protein] ligase.
Reaction catalysed
ATP + 3,4-dihydroxybenzoate + holo-[aryl-carrier protein] <=> AMP + diphosphate + 3,4-dihydroxybenzoyl-[aryl-carrier protein]
Comment(s)
  • The adenylation domain of the enzyme catalyzes the activation of 3,4- dihydroxybenzoate to (3,4-dihydroxybenzoyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein domain.
  • The aryl-carrier protein domain may be part of the same protein, or of a different protein.
  • This activity is often found as part of a larger non-ribosomal peptide synthase.
Cross-references
BRENDA6.2.1.62
EC2PDB6.2.1.62
ExplorEnz6.2.1.62
PRIAM enzyme-specific profiles6.2.1.62
KEGG Ligand Database for Enzyme Nomenclature6.2.1.62
IUBMB Enzyme Nomenclature6.2.1.62
IntEnz6.2.1.62
MEDLINEFind literature relating to 6.2.1.62
MetaCyc6.2.1.62
Rhea expert-curated reactions6.2.1.62
UniProtKB/Swiss-Prot
Q81RQ7, ASBC_BACAN

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