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ENZYME entry: EC 6.2.1.66

Accepted Name
Glyine--[glycyl-carrier protein] ligase.
Reaction catalysed
ATP + glycine + holo-[glycyl-carrier protein] <=> AMP + diphosphate + glycyl-[glycyl-carrier protein]
Comment(s)
  • The adenylation domain of the enzyme catalyzes the activation of glycine to (glycyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain.
  • The peptidyl-carrier protein domain may be part of the same protein (as in the case of DhbF in bacillibactin biosynthesis), or of a different protein.
  • This activity is often found as part of a larger non-ribosomal peptide synthase.
Cross-references
BRENDA6.2.1.66
EC2PDB6.2.1.66
ExplorEnz6.2.1.66
PRIAM enzyme-specific profiles6.2.1.66
KEGG Ligand Database for Enzyme Nomenclature6.2.1.66
IUBMB Enzyme Nomenclature6.2.1.66
IntEnz6.2.1.66
MEDLINEFind literature relating to 6.2.1.66
MetaCyc6.2.1.66
Rhea expert-curated reactions6.2.1.66

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-