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ENZYME entry: EC 6.2.1.71

Accepted Name
2,3-dihydroxybenzoate--[aryl-carrier protein] ligase.
Reaction catalysed
2,3-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate
Comment(s)
  • The adenylation domain of the enzyme catalyzes the activation of 2,3- dihydroxybenzoate to (2,3-dihydroxybenzoyl)adenylate, followed by the transfer the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein domain of a specific non-ribosomal peptide synthase.
  • For example, the EntE enzyme of Escherichia coli is part of the enterobactin synthase complex, the VibE enzyme of Vibrio cholerae is part of the vibriobactin synthase complex, and the DhbE enzyme of Bacillus subtilis is part of the bacillibactin synthase complex.
  • Formerly EC 2.7.7.58.
Cross-references
BRENDA6.2.1.71
EC2PDB6.2.1.71
ExplorEnz6.2.1.71
PRIAM enzyme-specific profiles6.2.1.71
KEGG Ligand Database for Enzyme Nomenclature6.2.1.71
IUBMB Enzyme Nomenclature6.2.1.71
IntEnz6.2.1.71
MEDLINEFind literature relating to 6.2.1.71
MetaCyc6.2.1.71
Rhea expert-curated reactions6.2.1.71
UniProtKB/Swiss-Prot
P40871, DHBE_BACSU;  Q8XBV3, ENTE_ECO57;  P10378, ENTE_ECOLI;  
O07899, VIBE_VIBCH;  

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