ENZYME entry: EC 6.2.1.71
Accepted Name |
2,3-dihydroxybenzoate--[aryl-carrier protein] ligase.
|
Reaction catalysed |
ATP + 2,3-dihydroxybenzoate + holo-[aryl-carrier protein] <=> AMP + diphosphate + 2,3-dihydroxybenzoyl-[aryl-carrier protein] |
Comment(s) |
- The adenylation domain of the enzyme catalyzes the activation of 2,3-
dihydroxybenzoate to (2,3-dihydroxybenzoyl)adenylate, followed by the
transfer the activated compound to the free thiol of a
phosphopantetheine arm of an aryl-carrier protein domain of a
specific non-ribosomal peptide synthase.
- For example, the EntE enzyme of Escherichia coli is part of the
enterobactin synthase complex, the VibE enzyme of Vibrio cholerae is
part of the vibriobactin synthase complex, and the DhbE enzyme of
Bacillus subtilis is part of the bacillibactin synthase complex.
- Formerly EC 2.7.7.58.
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Cross-references |
BRENDA | 6.2.1.71 |
EC2PDB | 6.2.1.71 |
ExplorEnz | 6.2.1.71 |
PRIAM enzyme-specific profiles | 6.2.1.71 |
KEGG Ligand Database for Enzyme Nomenclature | 6.2.1.71 |
IUBMB Enzyme Nomenclature | 6.2.1.71 |
IntEnz | 6.2.1.71 |
MEDLINE | Find literature relating to 6.2.1.71 |
MetaCyc | 6.2.1.71 |
Rhea expert-curated reactions | 6.2.1.71 |
UniProtKB/Swiss-Prot |
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