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ENZYME entry: EC 6.2.1.72

Accepted Name
L-serine--[L-seryl-carrier protein] ligase.
Alternative Name(s)
serine-activating enzyme.
Reaction catalysed
ATP + holo-[peptidyl-carrier protein] + L-serine <=> AMP + diphosphate + L-seryl-[peptidyl-carrier protein]
Comment(s)
  • The adenylation domain of the enzyme catalyzes the activation of L-serine to (L-seryl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain.
  • The peptidyl-carrier protein domain may be part of the same protein, or of a different protein.
  • This activity is often found as part of a larger non-ribosomal peptide synthase.
Cross-references
BRENDA6.2.1.72
EC2PDB6.2.1.72
ExplorEnz6.2.1.72
PRIAM enzyme-specific profiles6.2.1.72
KEGG Ligand Database for Enzyme Nomenclature6.2.1.72
IUBMB Enzyme Nomenclature6.2.1.72
IntEnz6.2.1.72
MEDLINEFind literature relating to 6.2.1.72
MetaCyc6.2.1.72
Rhea expert-curated reactions6.2.1.72
UniProtKB/Swiss-Prot
Q8XBV9, ENTF_ECO57;  P11454, ENTF_ECOLI;  P29698, ENTF_SHIFL;  
Q0E7C4, VABF_VIBAN;  Q7BQ71, ZMAJ_BACCE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-