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ENZYME entry: EC 6.4.1.1

Accepted Name
Pyruvate carboxylase.
Alternative Name(s)
Pyruvic carboxylase.
Reaction catalysed
ATP + pyruvate + HCO(3)(-) <=> ADP + phosphate + oxaloacetate
Cofactor(s)
Biotin; Mn(2+) or Zn(2+).
Comment(s)
The animal enzyme requires acetyl-CoA.
Cross-references
PROSITEPDOC00167 ; PDOC00676 ; PDOC50975 ; PDOC50979 ; PDOC50991
BRENDA6.4.1.1
EC2PDB6.4.1.1
ExplorEnz6.4.1.1
PRIAM enzyme-specific profiles6.4.1.1
KEGG Ligand Database for Enzyme Nomenclature6.4.1.1
IUBMB Enzyme Nomenclature6.4.1.1
IntEnz6.4.1.1
MEDLINEFind literature relating to 6.4.1.1
MetaCyc6.4.1.1
Rhea expert-curated reactions6.4.1.1
UniProtKB/Swiss-Prot
O17732, PYC1_CAEEL;  P11154, PYC1_YEAST;  P32327, PYC2_YEAST;  
O30019, PYCA_ARCFU;  Q58626, PYCA_METJA;  O27939, PYCA_METTH;  
Q58628, PYCB_METJA;  O27179, PYCB_METTH;  Q9HES8, PYC_ASPNG;  
O93918, PYC_ASPTE;  Q0CLK1, PYC_ASPTN;  Q9KWU4, PYC_BACSU;  
Q29RK2, PYC_BOVIN;  P11498, PYC_HUMAN;  Q05920, PYC_MOUSE;  
Q8X1T3, PYC_PICAN;  P78992, PYC_PICPA;  P52873, PYC_RAT;  
Q9UUE1, PYC_SCHPO;  A0A0H3JRU9, PYC_STAAM;  

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