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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.1.1.1

Accepted Name
Proton-translocating NAD(P)(+) transhydrogenase.
Reaction catalysed
NADPH + NAD(+) + H(+)(Side 1) <=> NADP(+) + H(+)(Side 2) + NADH
Comment(s)
  • The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane.
  • In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH.
  • Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme.
  • Formerly EC 1.6.1.5.
Cross-references
BRENDA7.1.1.1
EC2PDB7.1.1.1
ExplorEnz7.1.1.1
PRIAM enzyme-specific profiles7.1.1.1
KEGG Ligand Database for Enzyme Nomenclature7.1.1.1
IUBMB Enzyme Nomenclature7.1.1.1
IntEnz7.1.1.1
MEDLINEFind literature relating to 7.1.1.1
MetaCyc7.1.1.1
UniProtKB/Swiss-Prot
P11024, NNTM_BOVIN;  Q13423, NNTM_HUMAN;  Q61941, NNTM_MOUSE;  
Q2RSB2, PNTAA_RHORT;  P0C186, PNTAA_RHORU;  P41077, PNTAA_RICPR;  
Q2RSB3, PNTAB_RHORT;  P0C187, PNTAB_RHORU;  P51995, PNTAB_RICPR;  
P07001, PNTA_ECOLI;  P43842, PNTA_HAEIN;  Q9ALA2, PNTA_RHOSH;  
P0AB69, PNTB_ECO57;  P0AB68, PNTB_ECOL6;  P0AB67, PNTB_ECOLI;  
P43010, PNTB_HAEIN;  Q2RSB4, PNTB_RHORT;  P0C188, PNTB_RHORU;  
P0AB70, PNTB_SHIFL;  

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