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ENZYME

ENZYME entry: EC 7.1.1.12

PURL: https://purl.expasy.org/enzyme/EC/7.1.1.12
Accepted Name
succinate dehydrogenase (electrogenic, proton-motive force generating)
Reaction catalysed
a menaquinone + succinate + 2 H(+)(out) = a menaquinol + fumarate + 2 H(+)(in)
Comment(s)
  • The enzyme is very similar to EC 1.3.5.1 but differs by containing two heme molecules (located in the membrane anchor component) in addition to FAD and three iron-sulfur clusters.
  • Unlike EC 1.3.5.1, this enzyme catalyzes an electrogenic reaction, enabled by electron-bifurcation via the heme molecules.
  • In the direction of succinate oxidation by menaquinone, which is endergonic, the reaction is driven by the transmembrane electrochemical proton potential.
  • In the direction of fumarate reduction, the electrogenic electron transfer reaction is compensated by transmembrane proton transfer pathway known as the E-pathway, which results in overall electroneutrality.
Cross-references
BRENDA7.1.1.12
EC2PDB7.1.1.12
ExplorEnz7.1.1.12
KEGG Ligand Database for Enzyme Nomenclature7.1.1.12
IUBMB Enzyme Nomenclature7.1.1.12
MEDLINEFind literature relating to 7.1.1.12
MetaCyc7.1.1.12
Rhea expert-curated reactions7.1.1.12

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-