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ENZYME

ENZYME entry: EC 7.1.1.8

Accepted Name
quinol--cytochrome-c reductase
Alternative Name(s)
complex III (mitochondrial electron transport)
cytochrome bc1 complex
ubiquinol--cytochrome-c reductase
ubiquinone--cytochrome-c oxidoreductase
Reaction catalysed
a quinol + 2 Fe(III)-[cytochrome c](out) <=> a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
Comment(s)
  • The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain.
  • It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria.
  • The mammalian enzyme contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin.
  • Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3).
  • Formerly EC 1.10.2.2.
Cross-references
BRENDA7.1.1.8
EC2PDB7.1.1.8
ExplorEnz7.1.1.8
PRIAM enzyme-specific profiles7.1.1.8
KEGG Ligand Database for Enzyme Nomenclature7.1.1.8
IUBMB Enzyme Nomenclature7.1.1.8
IntEnz7.1.1.8
MEDLINEFind literature relating to 7.1.1.8
MetaCyc7.1.1.8
Rhea expert-curated reactions7.1.1.8
UniProtKB/Swiss-Prot
P25076, CY11_SOLTUP29610, CY12_SOLTUP00125, CY1_BOVIN
Q54D07, CY1_DICDIP20114, CY1_EUGGRP08574, CY1_HUMAN
Q00988, CY1_KLULAQ9D0M3, CY1_MOUSEP07142, CY1_NEUCR
O59680, CY1_SCHPOP07143, CY1_YEASTQ35128, CYB_NEUCR
P00163, CYB_YEASTQ8E8S0, CYMA_SHEONA0A1D8PHA3, CYT1_CANAL
P29677, MPPA_SOLTUQ6NGA3, QCRB_CORDIQ8FNR2, QCRB_COREF
Q79VE9, QCRB_CORGLP63886, QCRB_MYCBOP15878, QCRB_MYCLE
P9WP36, QCRB_MYCTOP9WP37, QCRB_MYCTUQ9X806, QCRB_STRCO
Q9ZFB6, QCRB_STRLIQ6NGA1, QCRC_CORDIQ8FNR0, QCRC_COREF
Q8NNK5, QCRC_CORGLP63888, QCRC_MYCBOO69583, QCRC_MYCLE
P9WP34, QCRC_MYCTOP9WP35, QCRC_MYCTUA0A1D8PJX3, RIP1_CANAL
Q94JS0, UCRI1_ARATHP49729, UCRI1_TOBACQ9LYR2, UCRI2_ARATH
P51132, UCRI2_TOBACP51133, UCRI3_TOBACP51134, UCRI4_TOBAC
P51135, UCRI5_TOBACO31214, UCRI_ALLVDQ69BJ9, UCRI_AOTAZ
P81380, UCRI_BLAVIP13272, UCRI_BOVINP51130, UCRI_BRADU
Q02762, UCRI_CERSPQ5ZLR5, UCRI_CHICKQ69BK1, UCRI_CHLAE
Q69BK0, UCRI_COLPOQ69BK4, UCRI_GORGOP47985, UCRI_HUMAN
Q69BJ8, UCRI_LAGLAP49727, UCRI_MAIZEQ9CR68, UCRI_MOUSE
P07056, UCRI_NEUCRQ69BK6, UCRI_PANPAQ69BK5, UCRI_PANTR
P05417, UCRI_PARDEQ69BK3, UCRI_PONPYP20788, UCRI_RAT
P0CY48, UCRI_RHOCAD5ANZ2, UCRI_RHOCBP23136, UCRI_RHORU
Q1RIA5, UCRI_RICBRQ92IR2, UCRI_RICCNQ4UKR6, UCRI_RICFE
Q9ZDQ5, UCRI_RICPRQ68XA0, UCRI_RICTYQ69BJ7, UCRI_SAISC
Q09154, UCRI_SCHPOP37841, UCRI_SOLTUQ69BJ6, UCRI_SYMSY
Q69BK2, UCRI_THEGEP08067, UCRI_YEAST

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