ENZYME entry: EC 7.2.1.4

PURL: https://purl.expasy.org/enzyme/EC/7.2.1.4

Accepted Name

tetrahydromethanopterin S-methyltransferase

Alternative Name(s)

N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase

tetrahydromethanopterin methyltransferase

Reaction catalysed

5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)

Comment(s)

Involved in the formation of methane from CO in methanogenic archaea.
The reaction involves the export of one or two sodium ions.
The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5'-hydroxybenzimidazolyl-cobamide cofactor, to which the methyl group is attached during the transfer.
A soluble enzyme that is induced by the presence of CO has been reported as well.
Formerly EC 2.1.1.86.

Cross-references

BRENDA

7.2.1.4

EC2PDB

7.2.1.4

ExplorEnz

7.2.1.4

KEGG Ligand Database for Enzyme Nomenclature

7.2.1.4

IUBMB Enzyme Nomenclature

7.2.1.4

MEDLINE

Find literature relating to 7.2.1.4

MetaCyc

7.2.1.4

Rhea expert-curated reactions

7.2.1.4

UniProtKB/Swiss-Prot

D3E045, MTRA1_METRM	O27227, MTRA1_METTH	P80184, MTRA1_METTM
D3E0P6, MTRA2_METRM	O27134, MTRA2_METTH	D9PXT1, MTRA2_METTM
A6UWH7, MTRA_META3	Q8TU03, MTRA_METAC	Q9Y8K4, MTRA_METBF
D7EBK7, MTRA_METEZ	C7P879, MTRA_METFA	Q2FRN2, MTRA_METHJ
Q58261, MTRA_METJA	O32867, MTRA_METKA	A6VHF2, MTRA_METM7
O59640, MTRA_METMA	Q6LWZ0, MTRA_METMP	D5E7Y7, MTRA_METMS
Q2NI29, MTRA_METST	D7DUI0, MTRA_METV3	A6UWH6, MTRB_META3
Q8TU02, MTRB_METAC	Q9Y8K3, MTRB_METBF	Q58260, MTRB_METJA
O32866, MTRB_METKA	A4FVW2, MTRB_METM5	A6VHF1, MTRB_METM7
P80655, MTRB_METMA	Q6LWZ1, MTRB_METMP	O27228, MTRB_METTH
Q59584, MTRB_METTM	A6UQK9, MTRB_METVS	Q8TU01, MTRC_METAC
Q9Y8K2, MTRC_METBF	Q58259, MTRC_METJA	O32865, MTRC_METKA
A4FVW3, MTRC_METM5	A6VHF0, MTRC_METM7	O59638, MTRC_METMA
Q6LWZ2, MTRC_METMP	O27229, MTRC_METTH	P80185, MTRC_METTM
A6UQK8, MTRC_METVS	Q8TU00, MTRD_METAC	Q9Y8K1, MTRD_METBF
Q58258, MTRD_METJA	O32864, MTRD_METKA	P80653, MTRD_METMA
Q6LWZ3, MTRD_METMP	O27230, MTRD_METTH	P80183, MTRD_METTM
A6UWH3, MTRE_META3	Q8TTZ9, MTRE_METAC	Q9Y8K0, MTRE_METBF
Q12VU4, MTRE_METBU	Q49176, MTRE_METFE	Q58257, MTRE_METJA
Q49606, MTRE_METKA	A4FVW5, MTRE_METM5	A6VHE8, MTRE_METM7
P80651, MTRE_METMA	Q6LWZ4, MTRE_METMP	O27231, MTRE_METTH
P80186, MTRE_METTM	Q50830, MTRE_METVA	A6UQK6, MTRE_METVS
Q8TU04, MTRF_METAC	Q9Y8K5, MTRF_METBF	Q58262, MTRF_METJA
Q8TVA7, MTRF_METKA	P80654, MTRF_METMA	O27226, MTRF_METTH
Q50773, MTRF_METTM	Q8TU05, MTRG_METAC	Q9Y8K6, MTRG_METBF
Q58263, MTRG_METJA	O32868, MTRG_METKA	P80656, MTRG_METMA
Q6LWY8, MTRG_METMP	O27225, MTRG_METTH	Q50774, MTRG_METTM
A6UWI0, MTRH_META3	Q8TU06, MTRH_METAC	O93716, MTRH_METBF
Q58264, MTRH_METJA	O32869, MTRH_METKA	A4FVV8, MTRH_METM5
P80650, MTRH_METMA	Q6LWY7, MTRH_METMP	O27224, MTRH_METTH
P80187, MTRH_METTM	A6UQL3, MTRH_METVS	P80652, TM2A_METMA

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