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ENZYME entry: EC 7.2.2.10

Accepted Name
P-type Ca(2+) transporter.
Alternative Name(s)
Ca(2+)-transporting ATPase.
Calcium pump.
Calcium-translocating P-type ATPase.
Reaction catalysed
ATP + H(2)O + Ca(2+)(Side 1) <=> ADP + phosphate + Ca(2+)(Side 2)
Cofactor(s)
Mg(2+).
Comment(s)
  • A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria.
  • The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed.
  • In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum.
  • Formerly EC 3.6.1.38 and EC 3.6.3.8.
Cross-references
PROSITEPDOC00139
BRENDA7.2.2.10
EC2PDB7.2.2.10
ExplorEnz7.2.2.10
PRIAM enzyme-specific profiles7.2.2.10
KEGG Ligand Database for Enzyme Nomenclature7.2.2.10
IUBMB Enzyme Nomenclature7.2.2.10
IntEnz7.2.2.10
MEDLINEFind literature relating to 7.2.2.10
MetaCyc7.2.2.10
Rhea expert-curated reactions7.2.2.10
UniProtKB/Swiss-Prot
Q9SZR1, ACA10_ARATH;  Q2QMX9, ACA10_ORYSJ;  Q9M2L4, ACA11_ARATH;  
Q9LY77, ACA12_ARATH;  Q9LIK7, ACA13_ARATH;  Q37145, ACA1_ARATH;  
Q8RUN1, ACA1_ORYSJ;  O81108, ACA2_ARATH;  Q6ATV4, ACA3_ORYSJ;  
O22218, ACA4_ARATH;  Q7X8B5, ACA5_ORYSJ;  Q65X71, ACA6_ORYSJ;  
O64806, ACA7_ARATH;  Q7XEK4, ACA7_ORYSJ;  Q9LF79, ACA8_ARATH;  
Q2RAS0, ACA8_ORYSJ;  Q9LU41, ACA9_ARATH;  Q2QY12, ACA9_ORYSJ;  
Q0VCY0, AT2A1_BOVIN;  P13585, AT2A1_CHICK;  O14983, AT2A1_HUMAN;  
P70083, AT2A1_MAKNI;  Q8R429, AT2A1_MOUSE;  Q92105, AT2A1_PELLE;  
P04191, AT2A1_RABIT;  Q64578, AT2A1_RAT;  O46674, AT2A2_CANLF;  
Q03669, AT2A2_CHICK;  Q00779, AT2A2_FELCA;  P16615, AT2A2_HUMAN;  
O55143, AT2A2_MOUSE;  P11607, AT2A2_PIG;  P20647, AT2A2_RABIT;  
P11507, AT2A2_RAT;  Q9YGL9, AT2A3_CHICK;  Q93084, AT2A3_HUMAN;  
Q64518, AT2A3_MOUSE;  O77696, AT2A3_PIG;  P18596, AT2A3_RAT;  
P86911, AT2A_CHIOP;  Q98SH2, AT2B1_CHICK;  P20020, AT2B1_HUMAN;  
G5E829, AT2B1_MOUSE;  P23220, AT2B1_PIG;  Q00804, AT2B1_RABIT;  
P11505, AT2B1_RAT;  Q01814, AT2B2_HUMAN;  Q9R0K7, AT2B2_MOUSE;  
P58165, AT2B2_OREMO;  P11506, AT2B2_RAT;  Q16720, AT2B3_HUMAN;  
Q64568, AT2B3_RAT;  D3K0R6, AT2B4_BOVIN;  P23634, AT2B4_HUMAN;  
Q6Q477, AT2B4_MOUSE;  Q64542, AT2B4_RAT;  P57709, AT2C1_BOVIN;  
P98194, AT2C1_HUMAN;  Q80XR2, AT2C1_MOUSE;  Q5R5K5, AT2C1_PONAB;  
Q64566, AT2C1_RAT;  O75185, AT2C2_HUMAN;  A7L9Z8, AT2C2_MOUSE;  
Q8R4C1, AT2C2_RAT;  Q7PPA5, ATC1_ANOGA;  P54678, ATC1_DICDI;  
P22700, ATC1_DROME;  Q292Q0, ATC1_DROPS;  O59868, ATC1_SCHPO;  
O43108, ATC1_YARLI;  P13586, ATC1_YEAST;  J9VQQ3, ATC2_CRYNH;  
Q9HDW7, ATC2_SCHPO;  P38929, ATC2_YEAST;  P22189, ATC3_SCHPO;  
O34431, ATCL_BACSU;  P37278, ATCL_SYNE7;  P35316, ATC_ARTSF;  
Q08853, ATC_PLAFK;  P35315, ATC_TRYBB;  Q73E41, BACA1_BACC1;  
Q47910, CDA_MYROD;  P0A505, CTPE_MYCBO;  A0R3Y2, CTPE_MYCS2;  
P9WPT0, CTPE_MYCTO;  P9WPT1, CTPE_MYCTU;  P92939, ECA1_ARATH;  
O23087, ECA2_ARATH;  Q9SY55, ECA3_ARATH;  Q9XES1, ECA4_ARATH;  
Q42883, ECAP_SOLLC;  Q9CFU9, LLCA1_LACLA;  Q8Y8Q5, LMCA1_LISMO;  

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