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ENZYME

ENZYME entry: EC 7.2.2.13

PURL: https://purl.expasy.org/enzyme/EC/7.2.2.13
Accepted Name
Na(+)/K(+)-exchanging ATPase
Alternative Name(s)
Na,K-activated ATPase
Na(+)/K(+)-ATPase
sodium/potassium-transporting ATPase
sodium pump
Reaction catalysed
K(+)(out) + Na(+)(in) + ATP + H2O = K(+)(in) + Na(+)(out) + ADP + phosphate + H(+)
Comment(s)
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed.
  • It is involved in generating the plasma membrane electrical potential.
  • Formerly EC 3.6.1.37 and EC 3.6.3.9.
Cross-references
BRENDA7.2.2.13
EC2PDB7.2.2.13
ExplorEnz7.2.2.13
KEGG Ligand Database for Enzyme Nomenclature7.2.2.13
IUBMB Enzyme Nomenclature7.2.2.13
MEDLINEFind literature relating to 7.2.2.13
MetaCyc7.2.2.13
Rhea expert-curated reactions7.2.2.13
UniProtKB/Swiss-Prot
P54707, AT12A_HUMANQ9Z1W8, AT12A_MOUSEQ9TV52, AT12A_RABIT
P54708, AT12A_RATQ92030, AT1A1_ANGANQ08DA1, AT1A1_BOVIN
P50997, AT1A1_CANLFP25489, AT1A1_CATCOP09572, AT1A1_CHICK
P18907, AT1A1_HORSEP05023, AT1A1_HUMANQ8VDN2, AT1A1_MOUSE
Q9YH26, AT1A1_OREMOP05024, AT1A1_PIGQ5RDR3, AT1A1_PONAB
Q9N0Z6, AT1A1_RABITP06685, AT1A1_RATP30714, AT1A1_RHIMB
P04074, AT1A1_SHEEPQ92123, AT1A1_XENLAA2VDL6, AT1A2_BOVIN
P24797, AT1A2_CHICKP50993, AT1A2_HUMANQ6PIE5, AT1A2_MOUSE
D2WKD8, AT1A2_PIGQ5RCD8, AT1A2_PONABP06686, AT1A2_RAT
P24798, AT1A3_CHICKP13637, AT1A3_HUMANQ6PIC6, AT1A3_MOUSE
P58312, AT1A3_OREMOP06687, AT1A3_RATQ13733, AT1A4_HUMAN
Q9WV27, AT1A4_MOUSEQ64541, AT1A4_RATP17326, AT1A_ARTSF
P35317, AT1A_HYDVUQ6RWA9, AT1A_TAESOP05025, AT1A_TETCF
P28774, AT1B_ARTSFP13607, ATNA_DROME

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.-.-
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