A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 7.2.2.13
| Accepted Name |
|---|
| Na(+)/K(+)-exchanging ATPase.
|
| Alternative Name(s) |
|---|
| Na(+)/K(+)-ATPase. |
| Na,K-activated ATPase. |
| Sodium pump. |
| Sodium/potassium-transporting ATPase. |
| Reaction catalysed |
|---|
| ATP + H(2)O + Na(+)(Side 1) + K(+)(Side 2) <=> ADP + phosphate + Na(+)(Side 2) + K(+)(Side 1) |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- P-type ATPase that undergoes covalent phosphorylation during the
transport cycle.
- An enzyme from the plasma membrane of animal cells that catalyzes the
efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed.
- It is involved in generating the plasma membrane electrical
potential.
- Formerly EC 3.6.1.37 and EC 3.6.3.9.
|
| Cross-references |
|---|
| PROSITE | PDOC00139 ; PDOC00328 |
| BRENDA | 7.2.2.13 |
| EC2PDB | 7.2.2.13 |
| ExplorEnz | 7.2.2.13 |
| PRIAM enzyme-specific profiles | 7.2.2.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 7.2.2.13 |
| IUBMB Enzyme Nomenclature | 7.2.2.13 |
| IntEnz | 7.2.2.13 |
| MEDLINE | Find literature relating to 7.2.2.13 |
| MetaCyc | 7.2.2.13 |
| UniProtKB/Swiss-Prot |
| Q92030, AT1A1_ANGAN; | Q08DA1, AT1A1_BOVIN; | P50997, AT1A1_CANLF; |
| P25489, AT1A1_CATCO; | P09572, AT1A1_CHICK; | P18907, AT1A1_HORSE; |
| P05023, AT1A1_HUMAN; | Q8VDN2, AT1A1_MOUSE; | Q9YH26, AT1A1_OREMO; |
| P05024, AT1A1_PIG; | Q5RDR3, AT1A1_PONAB; | Q9N0Z6, AT1A1_RABIT; |
| P06685, AT1A1_RAT; | P30714, AT1A1_RHIMB; | P04074, AT1A1_SHEEP; |
| Q92123, AT1A1_XENLA; | A2VDL6, AT1A2_BOVIN; | P24797, AT1A2_CHICK; |
| P50993, AT1A2_HUMAN; | Q6PIE5, AT1A2_MOUSE; | D2WKD8, AT1A2_PIG; |
| Q5RCD8, AT1A2_PONAB; | P06686, AT1A2_RAT; | P24798, AT1A3_CHICK; |
| P13637, AT1A3_HUMAN; | Q6PIC6, AT1A3_MOUSE; | P58312, AT1A3_OREMO; |
| P06687, AT1A3_RAT; | Q13733, AT1A4_HUMAN; | Q9WV27, AT1A4_MOUSE; |
| Q64541, AT1A4_RAT; | P17326, AT1A_ARTSF; | P35317, AT1A_HYDVU; |
| Q6RWA9, AT1A_TAESO; | P05025, AT1A_TETCF; | P28774, AT1B_ARTSF; |
| P13607, ATNA_DROME; |
|
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UniProtKB/Swiss-Prot entries corresponding to 7.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-