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ENZYME entry: EC 7.2.2.13

Accepted Name
Na(+)/K(+)-exchanging ATPase.
Alternative Name(s)
Na,K-activated ATPase.
Na(+)/K(+)-ATPase.
sodium/potassium-transporting ATPase.
sodium pump.
Reaction catalysed
ATP + H2O + K(+)(out) + Na(+)(in) <=> ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate
Comment(s)
  • P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
  • An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed.
  • It is involved in generating the plasma membrane electrical potential.
  • Formerly EC 3.6.1.37 and EC 3.6.3.9.
Cross-references
BRENDA7.2.2.13
EC2PDB7.2.2.13
ExplorEnz7.2.2.13
PRIAM enzyme-specific profiles7.2.2.13
KEGG Ligand Database for Enzyme Nomenclature7.2.2.13
IUBMB Enzyme Nomenclature7.2.2.13
IntEnz7.2.2.13
MEDLINEFind literature relating to 7.2.2.13
MetaCyc7.2.2.13
Rhea expert-curated reactions7.2.2.13
UniProtKB/Swiss-Prot
P54707, AT12A_HUMAN;  Q9Z1W8, AT12A_MOUSE;  Q9TV52, AT12A_RABIT;  
P54708, AT12A_RAT;  Q92030, AT1A1_ANGAN;  Q08DA1, AT1A1_BOVIN;  
P50997, AT1A1_CANLF;  P25489, AT1A1_CATCO;  P09572, AT1A1_CHICK;  
P18907, AT1A1_HORSE;  P05023, AT1A1_HUMAN;  Q8VDN2, AT1A1_MOUSE;  
Q9YH26, AT1A1_OREMO;  P05024, AT1A1_PIG;  Q5RDR3, AT1A1_PONAB;  
Q9N0Z6, AT1A1_RABIT;  P06685, AT1A1_RAT;  P30714, AT1A1_RHIMB;  
P04074, AT1A1_SHEEP;  Q92123, AT1A1_XENLA;  A2VDL6, AT1A2_BOVIN;  
P24797, AT1A2_CHICK;  P50993, AT1A2_HUMAN;  Q6PIE5, AT1A2_MOUSE;  
D2WKD8, AT1A2_PIG;  Q5RCD8, AT1A2_PONAB;  P06686, AT1A2_RAT;  
P24798, AT1A3_CHICK;  P13637, AT1A3_HUMAN;  Q6PIC6, AT1A3_MOUSE;  
P58312, AT1A3_OREMO;  P06687, AT1A3_RAT;  Q13733, AT1A4_HUMAN;  
Q9WV27, AT1A4_MOUSE;  Q64541, AT1A4_RAT;  P17326, AT1A_ARTSF;  
P35317, AT1A_HYDVU;  Q6RWA9, AT1A_TAESO;  P05025, AT1A_TETCF;  
P28774, AT1B_ARTSF;  P13607, ATNA_DROME;  

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