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ENZYME

ENZYME entry: EC 7.2.2.18

Accepted Name
ABC-type ferric citrate transporter
Alternative Name(s)
ferric citrate ABC transporter
ferric citrate transporting ATPase
Reaction catalysed
ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • The enzyme from Escherichia coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of Fe(3+)-citrate in the form of a mononuclear (containing one iron(III) ion and two citrate molecules) or dinuclear (containing 2 iron(III) ions) complexes.
Cross-references
BRENDA7.2.2.18
EC2PDB7.2.2.18
ExplorEnz7.2.2.18
PRIAM enzyme-specific profiles7.2.2.18
KEGG Ligand Database for Enzyme Nomenclature7.2.2.18
IUBMB Enzyme Nomenclature7.2.2.18
IntEnz7.2.2.18
MEDLINEFind literature relating to 7.2.2.18
MetaCyc7.2.2.18
Rhea expert-curated reactions7.2.2.18
UniProtKB/Swiss-Prot
P15031, FECE_ECOLI

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