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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.2.4.2

Accepted Name
Oxaloacetate decarboxylase (Na(+) extruding).
Alternative Name(s)
Oxalacetic acid decarboxylase.
Oxalate beta-decarboxylase.
Oxaloacetate beta-decarboxylase.
Reaction catalysed
Oxaloacetate + 2 Na(+)(Side 1) <=> pyruvate + CO(2) + 2 Na(+)(Side 2)
Comment(s)
  • The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA.
  • The process is accompanied by the extrusion of two sodium ions from cells.
  • Some animal enzymes require Mn(2+).
  • Differs from EC 4.1.1.112 (oxaloacetate decarboxylase) for which there is no evidence for involvement in Na(+) transport.
  • Formerly EC 4.1.1.3.
Cross-references
BRENDA7.2.4.2
EC2PDB7.2.4.2
ExplorEnz7.2.4.2
PRIAM enzyme-specific profiles7.2.4.2
KEGG Ligand Database for Enzyme Nomenclature7.2.4.2
IUBMB Enzyme Nomenclature7.2.4.2
IntEnz7.2.4.2
MEDLINEFind literature relating to 7.2.4.2
MetaCyc7.2.4.2
UniProtKB/Swiss-Prot
P13187, DCOA_KLEPN;  Q8XGX8, DCOA_SALTI;  Q03030, DCOA_SALTY;  
Q8Z9M6, OADB1_SALTI;  Q8ZRY4, OADB1_SALTY;  Q8Z3E5, OADB2_SALTI;  
Q03031, OADB2_SALTY;  Q9RF98, OADB_HAEDU;  P13156, OADB_KLEPN;  
Q9CL24, OADB_PASMU;  Q9KTU5, OADB_VIBCH;  Q5PKI8, OADG1_SALPA;  
Q8Z9M5, OADG1_SALTI;  P58651, OADG1_SALTY;  Q9KUH2, OADG1_VIBCH;  
Q5PJT2, OADG2_SALPA;  Q8Z3E4, OADG2_SALTI;  Q03032, OADG2_SALTY;  
Q9KTU4, OADG2_VIBCH;  P58650, OADG3_SALTY;  A3N223, OADG_ACTP2;  
B3GYF4, OADG_ACTP7;  A6VL34, OADG_ACTSZ;  B7LVP2, OADG_ESCF3;  
Q9RFA0, OADG_HAEDU;  A6T4H1, OADG_KLEP7;  P13155, OADG_KLEPN;  
Q65WL3, OADG_MANSM;  Q9CL26, OADG_PASMU;  B5F736, OADG_SALA4;  
A9MYH6, OADG_SALPB;  Q87LR6, OADG_VIBPA;  Q8DC44, OADG_VIBVU;  
Q7MHR9, OADG_VIBVY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-