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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.2.4.3

Accepted Name
(S)-methylmalonyl-CoA decarboxylase (sodium-transporting).
Alternative Name(s)
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase.
(S)-methylmalonyl-CoA carboxy-lyase.
Methylmalonyl-coenzyme A decarboxylase.
Reaction catalysed
(S)-methylmalonyl-CoA + Na(+)(Side 1) + H(+)(Side 2) <=> propanoyl-CoA + CO(2) + Na(+)(Side 2)
Cofactor(s)
Biotin.
Comment(s)
  • This bacterial enzyme couples the decarboxylation of (S)- methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na(+) across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.
  • It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
  • Formerly EC 4.1.1.41.
Cross-references
BRENDA7.2.4.3
EC2PDB7.2.4.3
ExplorEnz7.2.4.3
PRIAM enzyme-specific profiles7.2.4.3
KEGG Ligand Database for Enzyme Nomenclature7.2.4.3
IUBMB Enzyme Nomenclature7.2.4.3
IntEnz7.2.4.3
MEDLINEFind literature relating to 7.2.4.3
MetaCyc7.2.4.3
UniProtKB/Swiss-Prot
Q2HJD5, ECHD1_BOVIN;  F1NB38, ECHD1_CHICK;  F1R6N4, ECHD1_DANRE;  
Q9NTX5, ECHD1_HUMAN;  Q9D9V3, ECHD1_MOUSE;  Q5R4W0, ECHD1_PONAB;  
Q6AYG5, ECHD1_RAT;  Q5HZQ8, ECHD1_XENLA;  Q28C91, ECHD1_XENTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-