Home  |  Contact

ENZYME entry: EC 7.2.4.3

Accepted Name
(S)-methylmalonyl-CoA decarboxylase (sodium-transporting).
Alternative Name(s)
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase.
(S)-methylmalonyl-CoA carboxy-lyase.
Methylmalonyl-coenzyme A decarboxylase.
Reaction catalysed
(S)-methylmalonyl-CoA + Na(+)(Side 1) + H(+)(Side 2) <=> propanoyl-CoA + CO(2) + Na(+)(Side 2)
Cofactor(s)
Biotin.
Comment(s)
  • This bacterial enzyme couples the decarboxylation of (S)- methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na(+) across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.
  • It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
  • Formerly EC 4.1.1.41.
Cross-references
BRENDA7.2.4.3
EC2PDB7.2.4.3
ExplorEnz7.2.4.3
PRIAM enzyme-specific profiles7.2.4.3
KEGG Ligand Database for Enzyme Nomenclature7.2.4.3
IUBMB Enzyme Nomenclature7.2.4.3
IntEnz7.2.4.3
MEDLINEFind literature relating to 7.2.4.3
MetaCyc7.2.4.3

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-