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ENZYME

ENZYME entry: EC 7.2.4.3

PURL: https://purl.expasy.org/enzyme/EC/7.2.4.3
Accepted Name
(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)
Alternative Name(s)
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase
(S)-methylmalonyl-CoA carboxy-lyase
methylmalonyl-coenzyme A decarboxylase
Reaction catalysed
(S)-methylmalonyl-CoA + Na(+)(in) + H(+)(out) = propanoyl-CoA + Na(+)(out) + CO2
Comment(s)
  • This bacterial enzyme couples the decarboxylation of (S)- methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na(+) across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis.
  • It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.
  • Formerly EC 4.1.1.41.
Cross-references
BRENDA7.2.4.3
EC2PDB7.2.4.3
ExplorEnz7.2.4.3
KEGG Ligand Database for Enzyme Nomenclature7.2.4.3
IUBMB Enzyme Nomenclature7.2.4.3
MEDLINEFind literature relating to 7.2.4.3
MetaCyc7.2.4.3
Rhea expert-curated reactions7.2.4.3
UniProtKB/Swiss-Prot
O54028, MMDA_PROMOQ57079, MMDA_VEIPAO54031, MMDB_PROMO
Q57286, MMDB_VEIPAO54030, MMDC_PROMOQ57111, MMDC_VEIPA
O54029, MMDD_PROMOQ56724, MMDD_VEIPAQ57490, MMDE_VEIPA

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