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ENZYME

ENZYME entry: EC 7.4.2.14

PURL: https://purl.expasy.org/enzyme/EC/7.4.2.14
Accepted Name
ABC-type antigen peptide transporter
Reaction catalysed
a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + phosphate + H(+)
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • Does not undergo phosphorylation during the transport process.
  • This entry describes vertebrate transporters involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with major histocompatibility complex (MHC) class I molecules.
  • The substrates are generated mainly from degradation of cytosolic proteins by the proteasome.
Cross-references
BRENDA7.4.2.14
EC2PDB7.4.2.14
ExplorEnz7.4.2.14
KEGG Ligand Database for Enzyme Nomenclature7.4.2.14
IUBMB Enzyme Nomenclature7.4.2.14
MEDLINEFind literature relating to 7.4.2.14
MetaCyc7.4.2.14
Rhea expert-curated reactions7.4.2.14
UniProtKB/Swiss-Prot
Q28433, TAP1_GORGOQ03518, TAP1_HUMANP21958, TAP1_MOUSE
P36370, TAP1_RATQ03519, TAP2_HUMANP36371, TAP2_MOUSE
P36372, TAP2_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.4.2.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-