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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.5.2.6

Accepted Name
ABC-type lipid A-core oligosaccharide transporter.
Alternative Name(s)
ATP-dependent lipid A-core flippase.
Lipid flippase.
Reaction catalysed
ATP + H(2)O + lipid A-core oligosaccharide(Side 1) <=> ADP + phosphate + lipid A-core oligosaccharide(Side 2)
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway.
  • Not to be confused with EC 7.5.2.5, which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.
Cross-references
BRENDA7.5.2.6
EC2PDB7.5.2.6
ExplorEnz7.5.2.6
PRIAM enzyme-specific profiles7.5.2.6
KEGG Ligand Database for Enzyme Nomenclature7.5.2.6
IUBMB Enzyme Nomenclature7.5.2.6
IntEnz7.5.2.6
MEDLINEFind literature relating to 7.5.2.6
MetaCyc7.5.2.6
UniProtKB/Swiss-Prot
Q483B6, MSBA1_COLP3;  Q480N3, MSBA2_COLP3;  Q6F9X0, MSBA_ACIAD;  
Q0VQP5, MSBA_ALCBS;  Q5E0F2, MSBA_ALIF1;  Q0A4U4, MSBA_ALKEH;  
Q5P2S7, MSBA_AROAE;  Q7VR44, MSBA_BLOFL;  Q492S9, MSBA_BLOPB;  
Q2KYS6, MSBA_BORA1;  Q7WH20, MSBA_BORBR;  Q7W9N7, MSBA_BORPA;  
Q7VWD8, MSBA_BORPE;  Q1BUV6, MSBA_BURCA;  Q39E73, MSBA_BURL3;  
Q62IG3, MSBA_BURMA;  Q3JUI6, MSBA_BURP1;  Q63VX7, MSBA_BURPS;  
Q2SZW0, MSBA_BURTA;  Q1QX69, MSBA_CHRSD;  Q7NZU6, MSBA_CHRVO;  
Q83D84, MSBA_COXBU;  Q1LQD3, MSBA_CUPMC;  Q46Y89, MSBA_CUPNJ;  
Q47JR8, MSBA_DECAR;  Q6AJW3, MSBA_DESPS;  P60753, MSBA_ECO57;  
Q0TJD9, MSBA_ECOL5;  Q8FJB1, MSBA_ECOL6;  P60752, MSBA_ECOLI;  
Q1RDU4, MSBA_ECOUT;  Q47908, MSBA_FRANO;  Q14JW6, MSBA_FRAT1;  
Q2A1U9, MSBA_FRATH;  Q0BKJ3, MSBA_FRATO;  Q5NIG3, MSBA_FRATT;  
Q7VL52, MSBA_HAEDU;  Q4QPI4, MSBA_HAEI8;  P44407, MSBA_HAEIN;  
Q0I4C5, MSBA_HAES1;  Q2SIN5, MSBA_HAHCH;  Q31FG2, MSBA_HYDCU;  
Q5QU36, MSBA_IDILO;  Q5X498, MSBA_LEGPA;  Q5ZUH9, MSBA_LEGPH;  
Q5WVN2, MSBA_LEGPL;  Q65U21, MSBA_MANSM;  Q60AA3, MSBA_METCA;  
Q1GZI0, MSBA_METFK;  Q5F4X8, MSBA_NEIG1;  Q9JW59, MSBA_NEIMA;  
Q9JXR3, MSBA_NEIMB;  Q3J7R8, MSBA_NITOC;  Q142P6, MSBA_PARXL;  
Q9CMG7, MSBA_PASMU;  Q6D437, MSBA_PECAS;  Q7N6C6, MSBA_PHOLL;  
Q6LPK6, MSBA_PHOPR;  Q12C33, MSBA_POLSJ;  Q48P40, MSBA_PSE14;  
Q15UY7, MSBA_PSEA6;  Q9HUG8, MSBA_PSEAE;  Q4KJB2, MSBA_PSEF5;  
Q3IGX5, MSBA_PSEHT;  Q3KJ31, MSBA_PSEPF;  Q88D92, MSBA_PSEPK;  
Q87VF3, MSBA_PSESM;  Q4ZZ16, MSBA_PSEU2;  Q4FS42, MSBA_PSYA2;  
Q1QBW0, MSBA_PSYCK;  Q8XXB6, MSBA_RALSO;  Q21WN9, MSBA_RHOFT;  
Q21NS8, MSBA_SACD2;  Q57R14, MSBA_SALCH;  Q5PGH0, MSBA_SALPA;  
P63360, MSBA_SALTI;  P63359, MSBA_SALTY;  Q12M46, MSBA_SHEDO;  
Q080T2, MSBA_SHEFN;  Q8EDF0, MSBA_SHEON;  Q0HHH4, MSBA_SHESM;  
Q0HTS8, MSBA_SHESR;  Q31YT6, MSBA_SHIBS;  Q32E34, MSBA_SHIDS;  
Q83LP0, MSBA_SHIFL;  Q3Z3K7, MSBA_SHISS;  Q2NUA5, MSBA_SODGM;  
Q2LVL0, MSBA_SYNAS;  Q3SFZ6, MSBA_THIDA;  Q9KQW9, MSBA_VIBCH;  
Q87R16, MSBA_VIBPA;  Q8DAV2, MSBA_VIBVU;  Q7MJ07, MSBA_VIBVY;  
Q8D2U8, MSBA_WIGBR;  Q8PKS5, MSBA_XANAC;  Q3BTC8, MSBA_XANC5;  
Q4UV65, MSBA_XANC8;  Q8P8W4, MSBA_XANCP;  Q2P3E7, MSBA_XANOM;  
Q5H0H0, MSBA_XANOR;  Q9PEE7, MSBA_XYLFA;  Q87EF0, MSBA_XYLFT;  
Q1CA68, MSBA_YERPA;  Q8ZGA9, MSBA_YERPE;  Q1CGH0, MSBA_YERPN;  
Q66CI3, MSBA_YERPS;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.5.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-