ENZYME entry: EC 1.1.1.105
| Accepted Name |
|---|
| All-trans-retinol dehydrogenase (NAD(+)).
|
| Reaction catalysed |
|---|
| All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) <=> all-trans-retinal-[cellular-retinol-binding-protein] + NADH |
| Comment(s) |
|---|
- The enzyme recognizes all-trans-retinol and all-trans-retinal as
substrates and exhibits a strong preference for NAD(+)/NADH as
cofactors.
- Recognizes the substrate both in free form and when bound to
cellular-retinol-binding-protein (CRBP1), but has higher affinity for
the bound form.
- No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
- Also active with 3-alpha-hydroxysteroids.
|
| Cross-references |
|---|
| PROSITE | PDOC00060 |
| BRENDA | 1.1.1.105 |
| EC2PDB | 1.1.1.105 |
| ExplorEnz | 1.1.1.105 |
| PRIAM enzyme-specific profiles | 1.1.1.105 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.105 |
| IUBMB Enzyme Nomenclature | 1.1.1.105 |
| IntEnz | 1.1.1.105 |
| MEDLINE | Find literature relating to 1.1.1.105 |
| MetaCyc | 1.1.1.105 |
| UniProtKB/Swiss-Prot |
| Q3T001, H17B6_BOVIN; | O14756, H17B6_HUMAN; | Q9R092, H17B6_MOUSE; |
| O54753, H17B6_RAT; | P50170, RDH2_RAT; | P50169, RDH3_RAT; |
| O88451, RDH7_MOUSE; | P55006, RDH7_RAT; | Q8N3Y7, RDHE2_HUMAN; |
| Q7TQA3, RDHE2_MOUSE; |
|
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