ENZYME entry: EC 1.1.1.95

Accepted Name
Phosphoglycerate dehydrogenase.
Alternative Name(s)
3-phosphoglycerate dehydrogenase.
3-phosphoglyceric acid dehydrogenase.
3PHP reductase.
Alpha-KG reductase.
Alpha-phosphoglycerate dehydrogenase.
D-3-phosphoglycerate dehydrogenase.
Glycerate 3-phosphate dehydrogenase.
Glycerate-1,3-phosphate dehydrogenase.
PGDH.
Phosphoglycerate oxidoreductase.
Phosphoglyceric acid dehydrogenase.
Reaction catalysed
  • 3-phospho-D-glycerate + NAD(+) <=> 3-phosphonooxypyruvate + NADH
  • 2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + NADH
Comment(s)
  • Catalyzes the first committed step in the phosphoserine pathway of serine biosynthesis in Escherichia coli.
  • Reaction (1) occurs predominantly in the reverse direction and is inhibited by serine and glycine.
  • The enzyme is unusual in that it also acts as a D- and L-2- hydroxyglutarate dehydrogenase (with the D-form being the better substrate) and as a 2-oxoglutarate reductase.
Cross-references
PROSITEPDOC00063
BRENDA1.1.1.95
EC2PDB1.1.1.95
ExplorEnz1.1.1.95
PRIAM enzyme-specific profiles1.1.1.95
KEGG Ligand Database for Enzyme Nomenclature1.1.1.95
IUBMB Enzyme Nomenclature1.1.1.95
IntEnz1.1.1.95
MEDLINEFind literature relating to 1.1.1.95
MetaCyc1.1.1.95
UniProtKB/Swiss-Prot
P40510, SER33_YEAST;  O04130, SERA_ARATH;  O29445, SERA_ARCFU;  
P35136, SERA_BACSU;  Q5EAD2, SERA_BOVIN;  Q54UH8, SERA_DICDI;  
P0A9T2, SERA_ECO57;  P0A9T1, SERA_ECOL6;  P0A9T0, SERA_ECOLI;  
P43885, SERA_HAEIN;  O43175, SERA_HUMAN;  Q60HD7, SERA_MACFA;  
Q58424, SERA_METJA;  O27051, SERA_METTH;  Q61753, SERA_MOUSE;  
P0A545, SERA_MYCBO;  O33116, SERA_MYCLE;  P9WNX2, SERA_MYCTO;  
P9WNX3, SERA_MYCTU;  A5A6P1, SERA_PANTR;  A5GFY8, SERA_PIG;  
Q5R7M2, SERA_PONAB;  O08651, SERA_RAT;  P87228, SERA_SCHPO;  
P0A9T3, SERA_SHIFL;  P73821, SERA_SYNY3;  P40054, SERA_YEAST;  

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