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ENZYME entry: EC 1.1.1.95

Accepted Name
Phosphoglycerate dehydrogenase.
Alternative Name(s)
3-phosphoglycerate dehydrogenase.
3-phosphoglyceric acid dehydrogenase.
3PHP reductase.
Alpha-KG reductase.
Alpha-phosphoglycerate dehydrogenase.
D-3-phosphoglycerate dehydrogenase.
Glycerate 3-phosphate dehydrogenase.
Glycerate-1,3-phosphate dehydrogenase.
PGDH.
Phosphoglycerate oxidoreductase.
Phosphoglyceric acid dehydrogenase.
Reaction catalysed
3-phospho-D-glycerate + NAD(+) <=> 3-phosphonooxypyruvate + NADH
Comment(s)
  • Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis.
  • The reaction occurs predominantly in the direction of reduction.
  • The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399.
Cross-references
PROSITEPDOC00063
BRENDA1.1.1.95
EC2PDB1.1.1.95
ExplorEnz1.1.1.95
PRIAM enzyme-specific profiles1.1.1.95
KEGG Ligand Database for Enzyme Nomenclature1.1.1.95
IUBMB Enzyme Nomenclature1.1.1.95
IntEnz1.1.1.95
MEDLINEFind literature relating to 1.1.1.95
MetaCyc1.1.1.95
UniProtKB/Swiss-Prot
P40510, SER33_YEAST;  O49485, SERA1_ARATH;  O04130, SERA2_ARATH;  
Q9LT69, SERA3_ARATH;  O29445, SERA_ARCFU;  P35136, SERA_BACSU;  
Q5EAD2, SERA_BOVIN;  Q54UH8, SERA_DICDI;  P0A9T2, SERA_ECO57;  
P0A9T1, SERA_ECOL6;  P0A9T0, SERA_ECOLI;  P43885, SERA_HAEIN;  
O43175, SERA_HUMAN;  Q60HD7, SERA_MACFA;  Q58424, SERA_METJA;  
O27051, SERA_METTH;  Q61753, SERA_MOUSE;  P0A545, SERA_MYCBO;  
O33116, SERA_MYCLE;  P9WNX2, SERA_MYCTO;  P9WNX3, SERA_MYCTU;  
A5A6P1, SERA_PANTR;  A5GFY8, SERA_PIG;  Q5R7M2, SERA_PONAB;  
O08651, SERA_RAT;  P87228, SERA_SCHPO;  P0A9T3, SERA_SHIFL;  
P73821, SERA_SYNY3;  P40054, SERA_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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