ENZYME entry: EC 1.14.16.4

Accepted Name
Tryptophan 5-monooxygenase.
Alternative Name(s)
Indoleacetic acid-5-hydroxylase.
L-tryptophan hydroxylase.
Tryptophan 5-hydroxylase.
Tryptophan hydroxylase.
Reaction catalysed
L-tryptophan + tetrahydrobiopterin + O(2) <=> 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
Cofactor(s)
Fe cation.
Comment(s)
  • Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein kinase.
  • The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96.
  • The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
Cross-references
PROSITEPDOC00316
BRENDA1.14.16.4
EC2PDB1.14.16.4
ExplorEnz1.14.16.4
PRIAM enzyme-specific profiles1.14.16.4
KEGG Ligand Database for Enzyme Nomenclature1.14.16.4
IUBMB Enzyme Nomenclature1.14.16.4
IntEnz1.14.16.4
MEDLINEFind literature relating to 1.14.16.4
MetaCyc1.14.16.4
UniProtKB/Swiss-Prot
Q54XS1, PH4H_DICDI;  P17276, PH4H_DROME;  P70080, TPH1_CHICK;  
P17752, TPH1_HUMAN;  P17532, TPH1_MOUSE;  P17290, TPH1_RABIT;  
P09810, TPH1_RAT;  Q0EAB8, TPH2_HORSE;  Q8IWU9, TPH2_HUMAN;  
Q2HZ26, TPH2_MACMU;  Q8CGV2, TPH2_MOUSE;  Q8CGU9, TPH2_RAT;  
Q92142, TPH_XENLA;  

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