ENZYME entry: EC 1.16.1.8

Accepted Name
[Methionine synthase] reductase.
Alternative Name(s)
[Methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing).
Methionine synthase cob(II)alamin reductase (methylating).
Methionine synthase reductase.
Reaction catalysed
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP(+) <=> 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine
Cofactor(s)
FAD; FMN.
Comment(s)
  • The substrate of the enzyme is the inactivated [Co(II)] form of EC 2.1.1.13.
  • Electrons are transferred from NADPH to FAD to FMN.
  • Formerly EC 2.1.1.135.
Cross-references
BRENDA1.16.1.8
EC2PDB1.16.1.8
ExplorEnz1.16.1.8
PRIAM enzyme-specific profiles1.16.1.8
KEGG Ligand Database for Enzyme Nomenclature1.16.1.8
IUBMB Enzyme Nomenclature1.16.1.8
IntEnz1.16.1.8
MEDLINEFind literature relating to 1.16.1.8
MetaCyc1.16.1.8
UniProtKB/Swiss-Prot
Q4JIJ2, MTRR_BOVIN;  Q17574, MTRR_CAEEL;  Q9UBK8, MTRR_HUMAN;  
Q8C1A3, MTRR_MOUSE;  Q498R1, MTRR_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.16.1.-
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