|B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase.|
|Cobalamin-dependent methionine synthase.|
|Methionine synthase (cobalamin-dependent).|
|Methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase.|
|N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase.|
|N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase.|
|Vitamin B12 methyltransferase.|
|5-methyltetrahydrofolate + L-homocysteine <=> tetrahydrofolate + L-methionine|
- The enzyme becomes inactivated occasionally during its cycle by
oxidation of Co(I) to Co(II).
- Reactivation by reductive methylation is catalyzed by the enzyme
itself, with S-adenosyl-L-methionine as the methyl donor and a
- For the mammalian enzyme, the reducing system involves NADPH and
- In bacteria, the reducing agent is flavodoxin, and no further
catalyst is needed (the flavodoxin is kept in the reduced state by
NADPH and EC 18.104.22.168).
- Acts on the monoglutamate as well as the triglutamate folate,
in contrast with EC 22.214.171.124, which acts only on the triglutamate.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
|Q4JIJ3, METH_BOVIN; ||A8XY95, METH_CAEBR; ||Q09582, METH_CAEEL; |
|Q54P92, METH_DICDI; ||P13009, METH_ECOLI; ||Q99707, METH_HUMAN; |
|A6H5Y3, METH_MOUSE; ||Q49775, METH_MYCLE; ||O33259, METH_MYCTU; |
|Q9I2Q2, METH_PSEAE; ||O33465, METH_PSEPU; ||Q9Z2Q4, METH_RAT; |
|P37586, METH_SALTY; ||Q55786, METH_SYNY3; ||Q9KUW9, METH_VIBCH; |
|Q5E814, METH_VIBF1; ||Q9AJQ8, METH_VIBFI; ||Q87L95, METH_VIBPA; |
|Q8DCJ7, METH_VIBVU; ||Q7MHB1, METH_VIBVY; |
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